[en] Early detection and diagnosis of pathologies is an essential part of clinical practice. This continually drives improvements in imaging modalities and contrast agents. The challenge is always to obtain the most accurate images possible of lesions, but also to detect tissue microstructures or metabolic events. This means combining resolution and sensitivity with deep-tissue imaging. Here, we review examples of contrast agents used in the various biomedical imaging modalities currently in use (CT, US, MRI, SPECT, PET, Fluorescence). We will then take a closer look at photoacoustic imaging (PAI), because of its intrinsic resolution and sensitivity. The review is structured as follows: first, the principle of each technique is discussed, followed by a description of the characteristics that the dedicated contrast agents must meet. Third, recent examples of molecular and nanoparticulate contrast agents will be described. Finally, a special section will be devoted to bimodal contrast agents combining MRI and PAI imaging, showing that it is a very promising tandem.
Research center :
CMMI - Centre de Recherche en Microscopie et Imagerie Médicale
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others Life sciences: Multidisciplinary, general & others
Author, co-author :
Gosee, Camille ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale ; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Cadiou, Cyril; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Moreau, Juliette; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Callewaert, Maité; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Kowandy, Christelle; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Henoumont, Céline ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Larbanoix, Lionel ; Université de Mons - UMONS > Unités externes > Center for Microscopy and Molecular Imaging
Laurent, Sophie ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Chuburu, Françoise; University of Reims Champagne Ardenne, CNRS, ICMR UMR, Reims, France
Language :
English
Title :
Contrast enhancement in medical imaging: At the crossroads of techniques and contrast agents – Improvements over the last decade
R550 - Institut des Sciences et Technologies de la Santé R100 - Institut des Biosciences
Funding text :
The project leading to this publication has received funding from Universit\u00E9 de Reims Champagne-Ardenne and Universit\u00E9 de Mons (Camille Gos\u00E9e PhD fellowship). The authors would like to thank the \u201CProgramme de cooperation transfrontali\u00E8re Interreg France-Wallonie-Vlaanderen\u201D for its support through the \u201CNanocardio\u201D project, and Nano'Mat and PlAneT platforms (supported by the European Regional Development Fund and the Region Champagne Ardenne). The CMMI and its bioprofiling platform would like to thank the European Regional Development Fund and the Walloon Region for their financial support.
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