Article (Scientific journals)
Cytokeratins Biosensing Using Tilted Fiber Gratings
Loyez, Médéric; Albert, Jacques; Caucheteur, Christophe et al.
2018In Biosensors, 8(3) (74), p. 1-8
Peer reviewed
 

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Keywords :
[en] optical fiber grating; [en] Cytokeratin; [en] Biosensor
Abstract :
[en] Optical fiber gratings have widely proven their applicability in biosensing, especially when they are coupled with antibodies for specific antigen recognition. While this is customarily done with fibers coated by a thin metal film to benefit from plasmonic enhancement, in this paper, we propose to study their intrinsic properties, developing a label-free sensor for the detection of biomarkers in real-time without metal coatings for surface plasmon resonances. We focus on the inner properties of our modal sensor by immobilizing receptors directly on the silica surface, and reporting the sensitivity of bare tilted fiber Bragg gratings (TFBGs) used at near infrared wavelengths. We test different strategies to build our sensing surface against cytokeratins and show that the most reliable functionalization method is the electrostatic adsorption of antibodies on the fiber, allowing a limit of detection reaching 14 pM by following the guided cladding modes near the cut-off area. These results present the biodetection performance that TFBGs bring through their modal properties for different functionalizations and data processing strategies.
Disciplines :
Biochemistry, biophysics & molecular biology
Physics
Author, co-author :
Loyez, Médéric  ;  Université de Mons > Faculté des Sciences > Protéomie et Microbiologie
Albert, Jacques
Caucheteur, Christophe ;  Université de Mons > Faculté Polytechnique > Electromagnétisme et Télécommunications
Wattiez, Ruddy  ;  Université de Mons > Faculté des Sciences > Service de Protéomie et Microbiologie
Language :
English
Title :
Cytokeratins Biosensing Using Tilted Fiber Gratings
Publication date :
03 August 2018
Journal title :
Biosensors
Publisher :
MDPI, Basel, Switzerland
Volume :
8(3)
Issue :
74
Pages :
1-8
Peer reviewed :
Peer reviewed
Research unit :
S828 - Protéomie et Microbiologie
F108 - Electromagnétisme et Télécommunications
Research institute :
R100 - Institut des Biosciences
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