Article (Scientific journals)
Phenolic composition, in vitro antioxidant effects and tyrosinase inhibitory activity of three Algerian Mentha species: M. spicata (L.), M. pulegium (L.) and M. rotundifolia (L.) Huds (Lamiaceae)
Brahmi, Fatiha; Hauchard, D.; Guendouze, Naïma et al.
2015In Industrial Crops and Products, 74, p. 722-730
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Abstract :
[en] The leaves of three Mentha species harvested in Algeria, Mentha spicata L. (MS), Mentha pulegium L. (MP) and Mentha rotundifolia (L.) Huds (MR) were examined for their content in polyphenols and for some activities-linked biological properties these could impart. The contents in total phenolics (TPC) and flavonoids (TFC) were evaluated by the Folin-Ciocalteu and the aluminum chloride methods, respectively. Whereas MS showed the highest TPC (12.0±0.3mg gallic acid equivalents/g of dry weight), MR had the highest content in TFC (3.3±0.1mgquercetin equivalents of dry weight). The pharmacological properties of these extracts were evaluated by assessing in vitro their antioxidant and antityrosinase activities. The modulation of mushroom tyrosinase activity was measured by colorimetry of the melanins formed in the presence of tyrosine.MSexhibited the strongest radical scavenging activity (RSA) in all assays: (i) the IC50s values to neutralize the 2,2_-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) cation radicals (ABTS+) and the 2,2_-diphenyl-1-picrylhydrazyl radicals (DPPH.) were 10.3±0.9 and 16.2±0.2_g/mL, respectively; and (ii) its original electrochemically measured superoxide quenching index value is 188±37_g/mL (AI50). MR however showed the highest tyrosinase inhibitory activity (IC50 = 108±20_g/mL). A silica gel thin-layer chromatography (TLC) technique revealed the presence of caffeic and rosmarinic acids and diosmin in all extracts. These results were confirmed by high performance liquid chromatography with diode array detection (HPLC/DAD).
Disciplines :
Pharmacy, pharmacology & toxicology
Chemistry
Author, co-author :
Brahmi, Fatiha
Hauchard, D.
Guendouze, Naïma
Madani, K.
Kiendrebeogo, Martin
Kamagaju, L.
Stévigny, Caroline
Chibane, M.
Duez, Pierre  ;  Université de Mons > Faculté de Médecine et de Pharmacie > Chimie thérapeutique et Pharmacognosie
Language :
English
Title :
Phenolic composition, in vitro antioxidant effects and tyrosinase inhibitory activity of three Algerian Mentha species: M. spicata (L.), M. pulegium (L.) and M. rotundifolia (L.) Huds (Lamiaceae)
Publication date :
18 June 2015
Journal title :
Industrial Crops and Products
ISSN :
0926-6690
Publisher :
Elsevier, Netherlands
Volume :
74
Pages :
722-730
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
M136 - Chimie thérapeutique et Pharmacognosie
Research institute :
R550 - Institut des Sciences et Technologies de la Santé
Available on ORBi UMONS :
since 05 November 2015

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