A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry)

[en] A new polyaminocarboxylate ligand derived from N, C-pyrazolylpyridine was synthesized. The luminescence and relaxometry properties of its Tb3+ and Gd3+ chelates were investigated in aqueous solutions. The Tb3+ chelate is strongly luminescent having remarkable lifetime and quantum yield (tau = 1.82 ms and Phi = 0.42). The I/T-1 proton relaxivity at 20 MHz and 25 degrees C (5.3 s(-1) mM(-1)) of the Gd3+ chelate was found to be comparable to that of the clinically used Gd-DTPA.

Disciplines :

Radiology, nuclear medicine & imaging
Chemistry

Author, co-author :

Picard, C.

Geum, N.

Nasso, I.

Mestre, B.

Tisnes, P.

Laurent, Sophie ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Muller, Robert ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Vander Elst, Luce ; Université de Mons > Faculté de Médecine et de Pharmacie > Biochimie métabolique et moléculaire

Language :

English

Title :

A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry)

Publication date :

01 January 2006

Journal title :

Bioorganic and Medicinal Chemistry Letters

ISSN :

0960-894X

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

Pages :

5309-5312

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

M108 - Chimie générale, organique et biomédicale

Available on ORBi UMONS :

since 10 June 2010

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Bibliography

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