[en] Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reliability and the accuracy of T(1) and T(2) measurements rely on several experimental settings and on the equation used to fit the data. Examples of the importance of careful adjustment of the most important parameters are illustrated through several measurements performed on a low-resolution, low-magnetic field instrument. In addition, some specificities of T(1) and T(2) measurements on high-resolution, high-magnetic field spectrometers are pointed out.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Henoumont, Céline ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale
Vander Elst, Luce ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale
Laurent, Sophie ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale
Language :
English
Title :
How to perform accurate and reliable measurements of longitudinal and transverse relaxation times of MRI contrast media in aqueous solutions
Publication date :
01 January 2009
Journal title :
Contrast Media and Molecular Imaging
ISSN :
1555-4309
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Volume :
4
Issue :
6
Pages :
312-321
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
M108 - Chimie générale, organique et biomédicale
Research institute :
R550 - Institut des Sciences et Technologies de la Santé R100 - Institut des Biosciences
Muller RN. Contrast agents in magnetic resonance: operating mechanisms. In Encyclopedia of Nuclear Magnetic Resonance, Grant DM, Harris RK (eds). Wiley: New York, 1996; 1438-1444.
Bottrill M, Kwok L, Long NJ. Lanthanides in magnetic resonance imaging. Chem. Soc. Rev. 2006; 35: 557-571.
Chan KWY, Wong WT. Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging. Coord. Chem. Rev. 2007; 251: 2428-2451.
Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem. Rev. 2008; 108: 2064-2110.
Farrar TC, Becker ED. Pulse and Fourier Transform NMR. Academic Press: New York, 1971.
Bloembergen N, Pound RV. Radiation damping in magnetic resonance experiments. Phys. Rev. 1954; 95: 8-12.
Bloom S. Effects of radiation damping on spin dynamics. J. Appl. Phys. 1957; 28: 800-805.
Carr HY, Purcell EM. Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys. Rev. 1954; 94: 630-638.
Vold RL, Waugh JS, Klein MP, Phelps DE. Measurement of spin relaxation in complex systems. J. Chem. Phys. 1968; 48: 3831-3832.
