Fiber Bragg grating; Fiber optic biosensor; HER2 detection; Photonic crystal fiber; Sensor multiplexing; Surface plasmon resonance; Cascaded Bragg gratings; Cladding mode resonances; Epidermal growth factor receptor 2; Human epidermal growth factor; Human epidermal growth factor receptor 2 detection; Photonic-crystal fiber; Plasmonics; Sensors multiplexing; Surface-plasmon resonance; Electronic, Optical and Magnetic Materials; Instrumentation; Condensed Matter Physics; Surfaces, Coatings and Films; Metals and Alloys; Electrical and Electronic Engineering; Materials Chemistry
Abstract :
[en] Spectral multiplexing of biosensors in a single optical fiber has been a long-standing challenge, which we address here for the first time by combining photonic crystal fibers (PCF) with fiber Bragg grating technology. We exploit the features of the optical transmission spectrum of a straight fiber Bragg grating written in a PCF that allows exciting cladding mode resonances within a spectral span of about 60 nm, which is significantly narrower than the width of the transmission spectra of tilted gratings in standard single-mode step-index fibers. More specifically, we consider the cladding mode resonances that feature effective index values close to the refractive index of phosphate buffered saline, and we demonstrate plasmonic label-free biodetection of HER2 (human epidermal growth factor receptor 2) protein. We report on the simultaneous monitoring of the wavelength shifts of said cladding mode resonances from two spatially separated biofunctionalized Bragg gratings and we find that the PCF sensor is able to detect the protein concentration of 8.62 nM with high reproducibility.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Rusyakina, Olga; Brussels Photonics (B-PHOT), Vrije Universiteit Brussel and Flanders Make, Dept. of Applied Physics and Photonics, Brussels, Belgium ; Electromagnetism and Telecommunication Department, University of Mons, Mons, Belgium
Geernaert, Thomas; Brussels Photonics (B-PHOT), Vrije Universiteit Brussel and Flanders Make, Dept. of Applied Physics and Photonics, Brussels, Belgium
Loyez, Médéric ; Université de Mons - UMONS > Faculté des Sciences > Service de Protéomie et Microbiologie
Mergo, Pawel; Laboratory of Optical Fibres Technology, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, Lublin, Poland
Thienpont, Hugo; Brussels Photonics (B-PHOT), Vrije Universiteit Brussel and Flanders Make, Dept. of Applied Physics and Photonics, Brussels, Belgium
Proteomics and Microbiology Electromagnetism and Telecommunications
Research institute :
Biosciences
Funders :
Interreg Fonds De La Recherche Scientifique - FNRS Fonds Wetenschappelijk Onderzoek
Funding text :
This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS). The approach for an external refractometry and biosensing with PCFs with their multiplexing capability has been published on April 7th, 2022, as a patent application entitled “Microstructured optical fiber sensing device” under an international publication number WO 2022/069687 A1. Supplementary data. The file with supplementary data is available online.This work was supported in part by Fonds Wetenschappelijk Onderzoek (FWO) under Grants G0F6218N (EOS-convention 30467715), 12P1720N, and I013918N; in part by Interreg under Grant NWE758 (Fotonica pilootlijnen); in part by Industrial Research Fund (IOF); in part by Methusalem ; in part by the OZR of Vrije Universiteit Brussel; and in part by Fonds National de la Recherche Scientifique (F.R.S.-FNRS).
Rezapour Sarabi, M., Jiang, N., Ozturk, E., Yetisen, A.K., Tasoglu, S., “Biomedical optical fibers,”. Lab Chip vol. 21:4 (2021), 627–640.
Soares, M.S., et al. “Immunosensing based on optical fiber technology: recent advances,”. Biosensors, vol. 11(9),. 2021, 305.
Loyez, M., DeRosa, M.C., Caucheteur, C., Wattiez, R., “Overview and emerging trends in optical fiber aptasensing,”. Biosens. Bioelectron., vol. 196(September 2021),. 2022, 113694.
Lo Presti, D., et al. Fiber Bragg gratings for medical applications and future challenges: a review. IEEE Access vol. 8 (2020), 156863–156888.
Guo, T., González-Vila, Á., Loyez, M., Caucheteur, C., “Plasmonic optical fiber-grating immunosensing: a review,”. Sensors, vol. 17(12), 2017, 2732.
Chiavaioli, F., Gouveia, C., Jorge, P., Baldini, F., Towards a uniform metrological assessment of grating-based optical fiber sensors: from refractometers to biosensors. Biosensors, vol. 7(4), 2017, 23.
Loyez, M., et al. “Rapid detection of circulating breast cancer cells using a multiresonant optical fiber aptasensor with plasmonic amplification,”. ACS Sens. vol. 5:2 (2020), 454–463.
Lao, J., et al. “Gold nanoparticle-functionalized surface plasmon resonance optical fiber biosensor: in situ detection of thrombin with 1 n·M detection limit,”. J. Light. Technol. vol. 37:11 (2019), 2748–2755.
Fasseaux, H., Loyez, M., Chah, K., Caucheteur, C., “Phase interrogation of plasmonic tilted fiber Bragg grating biosensors through the Jones formalism,”. Opt. Express, vol. 30(19), 2022, 34287.
Loyez, M., et al. “In situ cancer diagnosis through online plasmonics,”. Biosens. Bioelectron. vol. 131:December 2018 (2019), 104–112.
Yu, X., et al. “Plasmonic enhanced fluorescence spectroscopy using side-polished microstructured optical fiber,”. Sens. Actuators B Chem. vol. 160:1 (2011), 196–201.
Danlard, I., Akowuah, E.K., “Assaying with PCF-based SPR refractive index biosensors: From recent configurations to outstanding detection limits,”. Opt. Fiber Technol., vol. 54(August 2019), 2020, 102083.
Liu, C., et al. “Birefringent PCF-Based SPR Sensor for a Broad Range of Low Refractive Index Detection,”. IEEE Photonics Technol. Lett. vol. 30:16 (2018), 1471–1474.
Peng, Lu, Shi, Fukun, Zhou, Guiyao, Ge, Shu, Hou, Zhiyun, Xia, Changming, “A surface plasmon biosensor based on a D-shaped microstructured optical fiber with rectangular lattice,”. IEEE Photonics J. vol. 7:5 (2015), 1–9.
Wang, A., Docherty, A., Kuhlmey, B.T., Cox, F.M., Large, M.C.J., “Side-hole fiber sensor based on surface plasmon resonance,”. Opt. Lett., vol. 34(24), 2009, 3890.
Wu, T., et al. “Surface plasmon resonance biosensor based on gold-coated side-polished hexagonal structure photonic crystal fiber,”. Opt. Express, vol. 25(17), 2017, 20313.
Du, H., Sun, X., Hu, Y., Dong, X., Zhou, J., “High sensitive refractive index sensor based on cladding etched photonic crystal fiber mach-zehnder interferometer,”. Photon. Sens. vol. 9:2 (2019), 126–134.
Rifat, A.A., et al. “Photonic crystal fiber based plasmonic sensors,”. Sens. Actuators B Chem. vol. 243 (2017), 311–325.
Yang, J., Che, X., Shen, R., Wang, C., Li, X., Chen, W., “High-sensitivity photonic crystal fiber long-period grating methane sensor with cryptophane-A-6Me absorbed on a PAA-CNTs/PAH nanofilm,”. Opt. Express, vol. 25(17), 2017, 20258.
Zhu, Y., He, Z., Du, H., “Detection of external refractive index change with high sensitivity using long-period gratings in photonic crystal fiber,”. Sens. Actuators B Chem. vol. 131:1 (2008), 265–269.
He, Z., Tian, F., Zhu, Y., Lavlinskaia, N., Du, H., “Long-period gratings in photonic crystal fiber as an optofluidic label-free biosensor,”. Biosens. Bioelectron. vol. 26:12 (2011), 4774–4778.
Huang, T., “Highly sensitive SPR Sensor Based on D-shaped Photonic Crystal Fiber Coated with Indium Tin Oxide at Near-Infrared Wavelength,”. Plasmonics vol. 12:3 (2017), 583–588.
Rifat, A.A., Ahmed, R., Mahdiraji, G.A., Adikan, F.R.M., “Highly Sensitive D-Shaped Photonic Crystal Fiber-Based Plasmonic Biosensor in Visible to Near-IR,”. IEEE Sens. J. vol. 17:9 (2017), 2776–2783.
Gangwar, R.K., Singh, V.K., “Highly Sensitive Surface Plasmon Resonance Based D-Shaped Photonic Crystal Fiber Refractive Index Sensor,”. Plasmonics, 2016, 1–6.
Chen, C., Laronche, A., Bouwmans, G., Bigot, L., Quiquempois, Y., Albert, J., “Sensitivity of photonic crystal fiber modes to temperature, strain and external refractive index,”. Opt. Express, vol. 16(13), 2008, 9645.
Jiang, X., Gu, Z., Zheng, L., “Cladding modes in photonic crystal fiber: characteristics and sensitivity to surrounding refractive index,”. Opt. Eng., vol. 55(1), 2016, 017106.
Zheng, S., Shan, B., Ghandehari, M., Ou, J., “Sensitivity characterization of cladding modes in long-period gratings photonic crystal fiber for structural health monitoring,”. Measurement vol. 72 (2015), 43–51.
Hoang, V.T., et al. “Optical properties of buffers and cell culture media for optofluidic and sensing applications,”. Appl. Sci., vol. 9(6), 2019, 1145.
Janeiro, R., Flores, R., Viegas, J., “Refractive index of phosphate-buffered saline in the telecom infrared C + L bands,”. OSA Contin., vol. 4(12), 2021, 3039.
Hong, R., et al. “A review of biosensors for detecting tumor markers in breast cancer,”. Life, vol. 12(3), 2022, 342.
Tan, L., Xu, Y., Yu, Y., Li, X., Chen, Y., Feng, Y., “Serum HER2 Level Measured by Dot Blot: A Valid and Inexpensive Assay for Monitoring Breast Cancer Progression,”. PLoS One, vol. 6(4), 2011, e18764.
Ranganathan, V., Srinivasan, S., Singh, A., DeRosa, M.C., “An aptamer-based colorimetric lateral flow assay for the detection of human epidermal growth factor receptor 2 (HER2),”. Anal. Biochem., vol. 588(August 2019), 2020, 113471.
Loyez, M., Lobry, M., Hassan, E.M., DeRosa, M.C., Caucheteur, C., Wattiez, R., “HER2 breast cancer biomarker detection using a sandwich optical fiber assay,”. Talanta, vol. 221(July 2020), 2021, 121452.
Rusyakina, O., et al. “Plasmon-enhanced refractometry through cladding mode excitation by a fiber bragg grating in photonic crystal fiber,”. J. Light. Technol. vol. 40:4 (2022), 1121–1129.
Qu, J.-H., Dillen, A., Saeys, W., Lammertyn, J., Spasic, D., “Advancements in SPR biosensing technology: An overview of recent trends in smart layers design, multiplexing concepts, continuous monitoring and in vivo sensing,”. Anal. Chim. Acta vol. 1104 (2020), 10–27.
Qu, J.H., Peeters, B., Delport, F., Vanhoorelbeke, K., Lammertyn, J., Spasic, D., “Gold nanoparticle enhanced multiplexed biosensing on a fiber optic surface plasmon resonance probe,”. Biosens. Bioelectron., vol. 192(August), 2021, 113549.
Baiad, M.D., Kashyap, R., “Concatenation of surface plasmon resonance sensors in a single optical fiber using tilted fiber Bragg gratings,”. Opt. Lett., vol. 40(1), 2015, 115.
Pesavento, M., De Maria, L., Merli, D., Marchetti, S., Zeni, L., Cennamo, N., “Towards the development of cascaded surface plasmon resonance POF sensors exploiting gold films and synthetic recognition elements for detection of contaminants in transformer oil,”. Sens. Bio-Sens. Res. vol. 13 (2017), 128–135.
Sciacca, B., François, A., Hoffmann, P., Monro, T.M., “Multiplexing of radiative-surface plasmon resonance for the detection of gastric cancer biomarkers in a single optical fiber,”. Sens. Actuators B Chem. vol. 183 (2013), 454–458.
NORIA – Fiber Bragg Grating manufacturing solution, NorthLab Photonics AB. https://www.nortshlabphotonics.com/products/fbg-manufacturing/produkt/noria-fiber-bragg-grating-manufacturing-solution-1/, 2023 (accessed 7 February 2023).
+1/-1 order phase masks (FBG), Ibsen Photonics. https://ibsen.com/products/phase-masks/1–1-order-phase-masks-fbg/, 2023 (accessed 6 February 2023).
Mortensen, N.A., Folkenberg, J.R., Nielsen, M.D., Hansen, K.P., “Modal cutoff and the V parameter in photonic crystal fibers,”. Opt. Lett., vol. 28(20), 2003, 1879.
Geernaert, T., et al. “Bragg Grating Inscription in GeO -Doped Microstructured Optical Fibers,”. J. Light. Technol. vol. 28:10 (2010), 1459–1467.
LAZERMaster LZM-100, specialty fusion splicer for fibre optic, AFL. https://www.fujikura.co.uk/products/FUSION-SPLICING/Specialty-Fusion-Splicers/FELLZM100_LAZERMaster-LZM-100, 2023 (accessed 6 February 2023).
Baghdasaryan, T., Geernaert, T., Berghmans, F., Thienpont, H., “Geometrical study of a hexagonal lattice photonic crystal fiber for efficient femtosecond laser grating inscription,”. Opt. Express, vol. 19(8), 2011, 7705.
Baghdasaryan, T., Geernaert, T., Thienpont, H., Berghmans, F., “Numerical modeling of femtosecond laser inscribed IR gratings in photonic crystal fibers,”. Opt. Express, vol. 23(2), 2015, 709.
Berghmans, F., Geernaert, T., Baghdasaryan, T., Thienpont, H., “Challenges in the fabrication of fibre Bragg gratings in silica and polymer microstructured optical fibres,”. Laser Photon. Rev. vol. 8:1 (2014), 27–52.
Chah, K., Kinet, D., Caucheteur, C., “Negative axial strain sensitivity in gold-coated eccentric fiber Bragg gratings,”. Sci. Rep., vol. 6(1), 2016, 38042.
Chah, K., Voisin, V., Kinet, D., Caucheteur, C., “Surface plasmon resonance in eccentric femtosecond-laser-induced fiber Bragg gratings,”. Opt. Lett., vol. 39(24), 2014, 6887.
Zhang, L., Qiao, X., Liu, Q., Shao, M., Jiang, Y., Huang, D., “Off-axis ultraviolet-written thin-core fiber Bragg grating for directional bending measurements,”. Opt. Commun. vol. 410:6 (2018), 197–201.
Dykstra, P.H., Roy, V., Byrd, C., Bentley, W.E., Ghodssi, R., “Microfluidic electrochemical sensor array for characterizing protein interactions with various functionalized surfaces,”. Anal. Chem. vol. 83:15 (2011), 5920–5927.
McEwen, G.D., Chen, F., Zhou, A., “Immobilization, hybridization, and oxidation of synthetic DNA on gold surface: Electron transfer investigated by electrochemistry and scanning tunneling microscopy,”. Anal. Chim. Acta vol. 643:1–2 (2009), 26–37.
Lobry, M., et al. “Multimodal plasmonic optical fiber grating aptasensor,”. Opt. Express, vol. 28(5), 2020, 7539.
Schasfoort, R.B.M., Handbook of Surface Plasmon Resonance. 2017, Royal Society of Chemistry, Cambridge.
Lobry, M., et al. “Plasmonic fiber grating biosensors demodulated through spectral envelopes intersection,”. J. Light. Technol. vol. 39:22 (2021), 7288–7295.
Cao, Y., et al. “High-resolution and temperature-compensational HER2 antigen detection based on a microwave photonic interrogation,”. Sens. Actuators, B Chem. vol. 245 (2017), 583–589.
Sypabekova, M., Amantayeva, A., Vangelista, L., González-Vila, Á., Caucheteur, C., Tosi, D., “Ultralow Limit Detection of Soluble HER2 Biomarker in Serum with a Fiber-Optic Ball-Tip Resonator Assisted by a Tilted FBG,”. ACS Meas. Sci. Au vol. 2:4 (2022), 309–316.
Lobry, M., et al. “HER2 biosensing through SPR-envelope tracking in plasmonic optical fiber gratings,”. Biomed. Opt. Express, vol. 11(9),. 2020, 4862.
“Thermo-Optic Coefficients,” in Handbook of Optical Constants of Solids, Elsevier, 1997, pp. 115–261.
Tosi, D., Review and analysis of peak tracking techniques for fiber bragg grating sensors. Sensors, vol. 17(10), 2017, 2368.
Esposito, F., et al. “Long period grating in double cladding fiber coated with graphene oxide as high-performance optical platform for biosensing,”. Biosens. Bioelectron., vol. 172(October 2020), 2021, 112747.
Caucheteur, C., Loyez, M., González-Vila, Á., Wattiez, R., “Evaluation of gold layer configuration for plasmonic fiber grating biosensors,”. Opt. Express, vol. 26(18), 2018, 24154.
Wang, W., et al. “A label-free fiber optic SPR biosensor for specific detection of C-reactive protein,”. Sci. Rep., vol. 7(1), 2017, 16904.
Lobry, M., Loyez, M., Debliquy, M., Chah, K., Goormaghtigh, E., Caucheteur, C., “Electro-plasmonic-assisted biosensing of proteins and cells at the surface of optical fiber,”. Biosens. Bioelectron., vol. 220(August 2022), 2023, 114867.
Xue, S.C., Large, M.C.J., Barton, G.W., Tanner, R.I., Poladian, L., Lwin, R., “Role of material properties and drawing conditions in the fabrication of microstructured optical fibers,”. J. Light. Technol. vol. 24:2 (2006), 853–860.
Mikhailov, S., et al. “Highly birefringent microstructured optical fiber for distributed hydrostatic pressure sensing with sub-bar resolution,”. Opt. Express, vol. 30(11), 2022, 19961.
Urrutia, A., Del Villar, I., Zubiate, P., Zamarreño, C.R., “A comprehensive review of optical fiber refractometers: toward a standard comparative criterion,”. Laser Photon. Rev., vol. 13(11), 2019, 1900094.
