Synthesis of aliphatic polycarbonate for transport of AO's and targeted delivery in gene therapy

The use of antisense oligomers into the cytoplasm of functional cells is a promising and challenging gene therapy strategy for neuromuscular disorders. While these therapeutics hold high promises, their administration is very challenging because of the rapid clearance from the bloodstream and the lack of tissue selectivity. Synthetic polymers have attracted attention in this field owing to the ease of synthesis and modification. Herein, we report the use of tailor-made aliphatic poly(carbonate)s synthetized by ring-opening polymerization using a metal-free and non-toxic catalyst. This family of polymers is biodegradable and biocompatible. First results and work plan are presented.