Ralstonia metallidurans, a bacterium specifically adapted to toxic metals: towards a catalogue of metal-responsive genes.

Mergeay, M.; Monchy, S.; Vallaeys, T.; Auquier, V.; Benotmane, A; Bertin, P; Taghavi, S.; Dunn, J.; van der Lelie, D.; Wattiez, Ruddy

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Ralstonia metallidurans, a bacterium specifically adapted to toxic metals: towards a catalogue of metal-responsive genes.

Mergeay, M.; Monchy, S.; Vallaeys, T. et al.

2003 • In FEMS Microbiology Reviews

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Abstract :

[en] Ralstonia metallidurans, formerly known as Alcaligenes eutrophus and thereafter as Ralstonia eutropha, is a beta-Proteobacterium colonizing industrial sediments, soils or wastes with a high content of heavy metals. The type strain CH34 carries two large plasmids (pMOL28 and pMOL30) bearing a variety of genes for metal resistance. A chronological overview describes the progress made in the knowledge of the plasmid-borne metal resistance mechanisms, the genetics of R. metallidurans CH34 and its taxonomy, and the applications of this strain in the fields of environmental remediation and microbial ecology. Recently, the sequence draft of the genome of R. metallidurans has become available. This allowed a comparison of these preliminary data with the published genome data of the plant pathogen Ralstonia solanacearum, which harbors a megaplasmid (of 2.1 Mb) carrying some metal resistance genes that are similar to those found in R. metallidurans CH34. In addition, a first inventory of metal resistance genes and operons across these two organisms could be made. This inventory, which partly relied on the use of proteomic approaches, revealed the presence of numerous loci not only on the large plasmids pMOL28 and pMOL30 but also on the chromosome. It suggests that metal-resistant Ralstonia, through evolution, are particularly well adapted to the harsh environments typically created by extreme anthropogenic situations or biotopes.

Disciplines :

Biochemistry, biophysics & molecular biology
Zoology

Author, co-author :

Mergeay, M.

Monchy, S.

Vallaeys, T.

Auquier, V.

Benotmane, A

Bertin, P

Taghavi, S.

Dunn, J.

van der Lelie, D.

Wattiez, Ruddy

Language :

English

Title :

Ralstonia metallidurans, a bacterium specifically adapted to toxic metals: towards a catalogue of metal-responsive genes.

Publication date :

01 June 2003

Journal title :

FEMS Microbiology Reviews

ISSN :

0168-6445

eISSN :

1574-6976

Publisher :

Oxford University Press, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S828 - Protéomie et Microbiologie

Available on ORBi UMONS :

since 14 January 2013

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Bibliography

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