Profil

Roch Alain

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Physique biomédicale


Main Research Fields
Chemistry
Radiology, nuclear medicine & imaging
Physics
Biochemistry, biophysics & molecular biology
Pharmacy, pharmacology & toxicology
Main Keywords
ELISA; functionalized iron oxide nanoparticles; cellular magnetic labeling; contrast agents; ferritin;
Main Unit & Research Centers
CMMI - Centre de Recherche en Microscopie et Imagerie Médicale
Main Co-authors
Vander Elst, Luce 
Muller, Robert 
Laurent, Sophie 
MULLER, Robert 
Gillis, Pierre 

Publications (total 57)

The most downloaded
6 downloads
Taboula Kayo, M., Kamdem Simo, M., Tagatsing Fotsing, M., Talla, E., Laurent, S., Vander Elst, L., Henoumont, C., Yankep, E., Ngenge, T., Keumoe, R., Atchade, A., Menkem Zeukoo, E., Lambert Sameza, M., Roch, A., Muller, R., Fekam Boyom, F., & Mbafor Tanyi, J. (2020). Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae). Natural Product Research. doi:10.1080/14786419.2020.1828409 https://hdl.handle.net/20.500.12907/10945
The most cited
5418 citations (Scopus®)
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. (01 January 2008). Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chemical Reviews, 108 (6), 2064-2110. doi:10.1021/cr068445e https://hdl.handle.net/20.500.12907/13113

Taboula Kayo, M., Kamdem Simo, M., Tagatsing Fotsing, M., Talla, E., Laurent, S., Vander Elst, L., Henoumont, C., Yankep, E., Ngenge, T., Keumoe, R., Atchade, A., Menkem Zeukoo, E., Lambert Sameza, M., Roch, A., Muller, R., Fekam Boyom, F., & Mbafor Tanyi, J. (2020). Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae). Natural Product Research. doi:10.1080/14786419.2020.1828409
Peer Reviewed verified by ORBi

Roch, A., Prodéo, J., Pierart, C., Muller, R., & Duez, P. (29 January 2019). The paramagnetic properties of malaria pigment, hemozoin, yield clues to a low-cost system for its trapping and determination. Talanta, 197, 553-557. doi:10.1016/j.talanta.2019.01.090
Peer Reviewed verified by ORBi

Vuong, Q. L., Gillis, P., Roch, A., & Gossuin, Y. (01 April 2017). Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in MRI: a theoretical review. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9 (6). doi:10.1002/wnan.1468
Peer reviewed

Duez, P., Roch, A., Blankert, B., Okusa, P. N., & Avaert, R. (06 May 2016). Malaria Detection: Pub. No. WO/2016/066754; International Application No PCT/EP2015/075144; Publication Date 06.05.2016; International Filing Date 29.10.2015.

Pinho, S., Laurent, S., Rocha, J., Roch, A., Delville, M.-H., Carlos, L., Vander Elst, L., Muller, R., & Geraldes, C. (01 January 2012). Relaxometric Studies of y-Fe203@SiO2 Core Shell Nanoparticles : When the coating Matters. Journal of Physical Chemistry. C, Nanomaterials and interfaces, 116(3), 2285-2291.
Peer Reviewed verified by ORBi

Ye, F., Laurent, S., Fornara, A., Astolfi, L., Qin, J., Roch, A., Martini, A., Toprak, M., Muller, R., & Muhammed, M. (2012). Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient nontoxic MRI T2 contrast agent with tunable proton relaxivities. Contrast Media and Molecular Imaging, 7 (5), 460-468.
Peer Reviewed verified by ORBi

Muller, R., Pinho, S. L., Laurent, S., Roch, A., Vander Elst, L., & Geraldes, C. (2011). Coating and its influence on the relaxivity of MRI superparamagnetic nanoparticles. Paper presented at Contrast Media Research, CMR 2011, UTMB, Galveston, Texas, United States - Texas.

Pinho, S. L., Laurent, S., Rocha, J., Roch, A., Delville, M., carlos, L. D., Vander Elst, L., Muller, R., & Geraldes, C. (06 October 2011). Coating and its influence on the relaxivity of MRI superparamagnetic nanoparticles. Paper presented at 28th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Leipzig, Germany.

Liu, F., Laurent, S., Roch, A., Vander Elst, L., & Muller, R. (13 September 2011). Size-controllable synthesis of CoFe2O4 nanoparticles and investigation on their magnetic properties. Paper presented at Réunion SRC, Institut Meurice, Bruxelles, Belgium.

Burtea, C., Laurent, S., Mahieu, I., Larbanoix, L., Roch, A., Port, M., Rousseaux, O., Ballet, S., Murariu, O., Toubeau, G., Corot, C., Vander Elst, L., & Muller, R. (01 July 2011). In vitro biomedical applications of functionalized iron oxide nanoparticles, including those not related to magnetic properties. Contrast Media and Molecular Imaging, 6, 236-250. doi:10.1002/cmmi.423
Peer Reviewed verified by ORBi

Vander Elst, L., Geraldes, C., Pinho, S., Laurent, S., Roch, A., & Muller, R. (02 June 2011). NMRD profiles of particulate reporters for magnetic resonance molecular imaging. Does the coating matters ? Paper presented at 7th conference on field cycling NMR relaxometry, Turin, Italy.

Burtea, C., Laurent, S., Mahieu, I., Larbanoix, L., Roch, A., Port, M., Rousseaux, O., Ballet, S., Murariu, O., Toubeau, G., Corot, C., Vander Elst, L., & Muller, R. (29 December 2010). In vitro biomedical applications of functionalized iron oxide nanoparticles, including those not related to magnetic properties. Contrast Media and Molecular Imaging, 6 (4), 236-50. doi:10.1002/cmmi.423
Peer Reviewed verified by ORBi

Forge, D., Gossuin, Y., Roch, A., Laurent, S., Vander Elst, L., & Muller, R. (01 January 2010). Development of magnetic chromatography to sort polydisperse nanoparticles in ferrofluids. Contrast Media and Molecular Imaging, 5 ((3)), 126-132.
Peer Reviewed verified by ORBi

Vuong, Q. L., Roch, A., Gillis, P., & Gossuin, Y. (05 July 2009). Simulation of NMR relaxation induced by SPM particles in solution. Poster session presented at Euromar 2009, Göteborg, Sweden.

Gossuin, Y., Gillis, P., Hocq, A., Vuong, Q. L., & Roch, A. (11 March 2009). Magnetic resonance relaxation properties of superparamagnetic particles. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1 (3).
Peer reviewed

Gossuin, Y., Gillis, P., Hocq, A., Vuong, Q. L., & Roch, A. (01 January 2009). Magnetic resonance relaxation properties of superparamagnetic particles. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 1 (3), 299-310. doi:10.1002/wnan.36
Peer reviewed

Forge, D., Roch, A., Laurent, S., Tellez, H., Gossuin, Y., Renaux, F., Vander Elst, L., & Muller, R. (17 November 2008). Optimization of the Synthesis of Superparamagnetic Contrast Agents by the Design of Experiments Method. Journal of Physical Chemistry. C, Nanomaterials and interfaces, 112 (49), 19178-19185. doi:10.1021/jp803832k
Peer Reviewed verified by ORBi

Forge, D., Laurent, S., Roch, A., Gossuin, Y., Vander Elst, L., & Muller, R. (01 January 2008). Preparation and characterization of organosilane modified magnetite nanoparticles. Poster session presented at Chimie et matériaux fonctionnels, GFSM (groupe francophone spectrométrie Mössbauer), UCL, Louvian-la-Neuve, Belgium.

Forge, D., Laurent, S., Roch, A., Gossuin, Y., Vander Elst, L., & Muller, R. (01 January 2008). Organosilane modified magnetite nanoparticles : synthesis and characterization. Poster session presented at COST D38 Metal-Based Systems for molecular imaging application, Sacavém, Portugal.

Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. (01 January 2008). Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chemical Reviews, 108 (6), 2064-2110. doi:10.1021/cr068445e
Peer Reviewed verified by ORBi

Laurent, S., Vander Elst, L., Roch, A., & Muller, R. (2007). Structure, synthesis and characterization of contrast agents for magnetic resonance molecular imaging. In NMR-MRI, µSR and Mössbauer Spectroscopies in Molecular Magnets (pp. 71-88). Springer-Verlag Italie. doi:10.1007/978-88-470-0532-7_3

Diallo, M. S. T., Camara, A. K., Vander Elst, L., Roch, A., Laurent, S., Baldé, A. M., & Muller, R. (01 January 2007). Ethnobotanic and phytochimic investigations of Hymenocardia acida Tul. dand Lantana will camara Linn, plants employed in traditionnal medicine. Poster session presented at 'New drugs and drug candidates : recent achievements in medicine chemistry', annual meeting on medicinal chemistry of SRC and KVCV, UCB, Braine-l'Alleud, Belgium.

Diallo, M. S. T., Camara, A. K., Vander Elst, L., Roch, A., Laurent, S., Baldé, A. M., & Muller, R. (01 January 2007). Ethnobotanic and phytochimic investigations of Hymenocardia acida Tul. and Lantana will camara Linn, plants employed in traditionnal medicine. Poster session presented at Annual meeting on medicinal chemistry of SRC and KVCV, UCB, Braine-l'Alleud, Belgium.

Forge, D., Laurent, S., Roch, A., Renaux, F., Vander Elst, L., & Muller, R. (01 January 2007). Optimization of the synthesis of superparamagnetic reporters for molecular imaging applications. Poster session presented at 5th conference on Field Cycling NMR relaxometry, Turin, Italy.

Qin, J., Laurent, S., Roch, A., Muller, R., & Mohammed, M. (01 January 2007). Monodisperse water-soluble superparamagnetic iron oxide nanoparticles revaled as a high performance T2 contrast agent for MRI. Poster session presented at European Society for molecular imaging, Second International Conference, (ESMI), Naples, Italy.

Qin, J., Laurent, S., Suk, Y., Roch, A., Mikhaylova, M., Muller, R., & Muhammed, M. (2007). Monodisperse Water-Soluble Superparamagnetic Iron Oxide Nanoparticles Revealed as High-Performance T2 Contrast Agents. Advanced Materials.
Peer reviewed

Forge, D., Laurent, S., Renaux, F., Gossuin, Y., Roch, A., Vander Elst, L., & Muller, R. (01 January 2007). Optimization of the synthesis of superparamagnetic reporters for molecular imaging by the experimental design method. Poster session presented at COST Chemistry D38, 'Metal based systems for molecular imaging applications', Eindhoven, Netherlands.

Qin, J., Laurent, S., Jo, Y. S., Roch, A., Mikhaylova, M., Bhujwalla, Z. M., Muller, R., & Muhammed, M. (01 January 2007). A high-performance magnetic resonance imaging T-2 contrast agent. Advanced Materials, 19 (14), 1874-1878. doi:10.1002/adma.200602326
Peer reviewed

Qin, J., Laurent, S., Jo, Y. S., Roch, A., Mikhaylova, M., Bhujwalla, Z. M., Muller, R., & Muhammed, M. (2007). A High-Performance Magnetic Resonance Imaging T2 Contrast Agent. Advanced Materials.
Peer reviewed

Qin, J., Laurent, S., Roch, A., Muller, R., & Muhammed, M. (01 January 2006). Superparamagnetic iron oxide micelles revealed as high performance T2 contrast agents. Poster session presented at 'New Developments in Contrast Agent Research', 10th Bi-annual Conference on Molecular Imaging, Magnetic Resonance Imaging and Intermodality Contrast Agent Research, Vilnius, Lithuania.

Forge, D., Tellez, H., Laurent, S., Gossuin, Y., Roch, A., Vander Elst, L., & Muller, R. (01 January 2006). Application of the experiment design method to the synthesis of superparamagnetic colloids. Poster session presented at Symposium on 'Magnetic separation and nanomagnetics', Université de Karlsruhe, Germany.

Qin, J., Laurent, S., Roch, A., Muller, R., & Muhammed, M. (01 January 2006). Fe2O3@Poly(L,L-lactide) Core-Shell Nanoparticles Synthesized by Surface-initiated In Situ Polymerization. Poster session presented at 6th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Krems, Austria.

De Marco, G., Roch, A., Perreti, I., Gossuin, Y., Lehman, P., Menuel, C., Vallée, J. N., & Muller, R. (01 January 2006). Agents de contraste en IRM : approche théorique des mécanismes de relaxation. Médecine Nucléaire: Imagerie Fonctionnelle et Métabolique, 30, 645-658.
Peer reviewed

Muller, R., Ouakssim, A., Fastrez, S., Roch, A., Laurent, S., Gossuin, Y., Pierart, C., & Vanderelst, L. (01 May 2005). Develoment of superparamagnetic particles dispersions : basic materials of markers for molecular imaging. Academic Radiology, 12 (Issue 5, S1), 45. doi:10.1016/j.acra.2005.02.033
Peer Reviewed verified by ORBi

Forge, D., Laurent, S., Roch, A., Vander Elst, L., & Muller, R. (01 January 2005). Intérêt des profils NMRD (Nuclear Magnetic Relaxation Dispersion) pour la caractérisation des particules superparamagnétiques. Poster session presented at Club Nanomatériaux pour les Sciences du Vivant, Défis et enjeux des colloïdes pour les techniques d'imageries appliquées aux méthodes de diagnostic in vivo, Paris, France.

Forge, D., Laurent, S., Roch, A., Boutry, S., Vander Elst, L., & Muller, R. (01 January 2005). Synthèse et évaluation de la capture cellulaire de particules superparamagnétiques. Poster session presented at Colloque Nano-hybrides, Autrans, Vercors, France.

Roch, A., Gossuin, Y., Muller, R., & Gillis, P. (01 January 2005). Superparamagnetic colloid suspensions: Water magnetic relaxation and clustering. Journal of Magnetism and Magnetic Materials, 293 (1), 532-539. doi:10.1016/j.jmmm.2005.01.070
Peer Reviewed verified by ORBi

Burtea, C., Laurent, S., Roch, A., Vander Elst, L., & Muller, R. (01 January 2005). C-MALISA (cellular magnetic-linked immunosorbent assay), a new application of cellular ELISA for MRI. Journal of Inorganic Biochemistry, 99 (5), 1135-1144. doi:10.1016/j.jinorgbio.2005.02.009
Peer Reviewed verified by ORBi

Gossuin, Y., Burtea, C., Monseux, A., Toubeau, G., Roch, A., Muller, R., & Gillis, P. (11 May 2004). Ferritin-induced relaxation in tissues: An in vitro study. Journal of Magnetic Resonance Imaging, 20 (4), 690-697. doi:10.1002/jmri.20152
Peer Reviewed verified by ORBi

Laurent, S., Roch, A., Gossuin, Y., Ouakssim, A., Vander Elst, L., & Muller, R. (01 January 2004). Synthesis and physico-chemical characterization of iron oxide nanoparticles grafted by vectorizing molecules. Poster session presented at -, Anvers, Belgium.

Ouakssim, A., Fastrez, S., Roch, A., Laurent, S., Gossuin, Y., Pierart, C., Vander Elst, L., & Muller, R. (01 January 2004). Control of the synthesis of magnetic fluids by relaxometry and magnetometry. Journal of Magnetism and Magnetic Materials, 272-276, 1711-e1713.
Peer Reviewed verified by ORBi

Burtea, C., Laurent, S., Roch, A., Vander Elst, L., & Muller, R. (01 January 2004). Highly sensitive Streptavidin-based magnetic nanosensors as an useful tool in clinical diagnosis. Poster session presented at 21th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Copenhague, Denmark.

Laurent, S., Ouakssim, A., Nicotra, C., Gossuin, Y., Roch, A., Vander Elst, L., Cornant, M., Soleil, P., & Muller, R. (01 January 2004). Influence of the length of the coating molecules on the nuclear magnetic relaxivity of superparamagnetic colloids. Physica Status Solidi A. Applications and Materials Science, 1 ((12)), 3644-3650.
Peer Reviewed verified by ORBi

Laurent, S., Ouakssim, A., Roch, A., Gossuin, Y., Pierart, C., Vander Elst, L., & Muller, R. (01 January 2003). Vectorized nanoparticles, a powerful class of contrast agent for MRI. Poster session presented at International Conference on Magnesium, ICM 2003, Rome, Italy.

Muller, R., Ouakssim, A., Fastrez, S., Roch, A., Laurent, S., Gossuin, Y., Pierart, C., & Vander Elst, L. (01 January 2003). Field Cycling relaxometry, an efficient tool for the quality control of superparamagnetic particles dispersions. Poster session presented at 3rd Field Cycling Magnetic Relaxation Conference, Torino, Italy.

Roch, A., Ouakssim, A., Fastrez, S., Laurent, S., Gossuin, Y., Pierart, C., Vander Elst, L., & Muller, R. (01 January 2003). Relaxometry of nanomagnets suspensions : theories and applications. Poster session presented at Sixth IBRO World Congress of Neuroscience, Prague, Czechia.

Muller, R., Ouakssim, A., Fastrez, S., Roch, A., Laurent, S., Gossuin, Y., Pierart, C., & Vander Elst, L. (01 January 2003). Development of Superparamagnetic Particles Dispersions Basic Materials of Markers for Molecular Imaging. Paper presented at CMR-2003, San Diego, United States - California.

Ouakssim, A., Fastrez, S., Roch, A., Laurent, S., Gossuin, Y., Pierart, C., Vander Elst, L., & Muller, R. (01 January 2003). Control of the synthesis of magnetic fluids by proton relaxometry. Poster session presented at International Conference on Magnetism, ICM 2003, Rome, Italy.

Gossuin, Y., Roch, A., Muller, R., Gillis, P., & Lo Bue, F. (08 December 2002). Anomalous Nuclear Magnetic Relaxation of Aqueous Solutions of Ferritin: An Unprecedented First-Order Mechanism. Magnetic Resonance in Medicine, 48, 959-964.
Peer Reviewed verified by ORBi

Gossuin, Y., Roch, A., Muller, R., Gillis, P., & Lo Bue, F. (15 September 2002). Anomalous Nuclear Magnetic Relaxation of Aqueous Solutions of Ferritin: An Unprecedented First-Order Mechanism. Magnetic Resonance in Medicine, 48, 959-964. doi:10.1002/mrm.10316
Peer Reviewed verified by ORBi

Gossuin, Y., Roch, A., Muller, R., & Gillis, P. (2002). An evaluation of the contributions of diffusion and exchange in relaxation enhancement by MRI contrast agents. Journal of Magnetic Resonance.
Peer Reviewed verified by ORBi

Gossuin, Y., Colet, J.-M., Roch, A., Muller, R., & Gillis, P. (08 June 2002). Cesium Adsorption in Hydrated Iron Oxide Particles Suspensions: An NMR Study. Journal of Magnetic Resonance, 157, 132-136. doi:10.1006/jmre.2002.2581
Peer Reviewed verified by ORBi

Gillis, P., Moiny, F., Muller, R. N., & Roch, A. (2002). Water Magnetic Relaxation in Superparamagnetic Colloid Suspensions: The effect of Agglomeration. Magnetic Resonance in Colloid and Interface Science, 383-392.
Peer reviewed

Vander Elst, L., Roch, A., Gillis, P., Laurent, S., Botteman, F., Bulte, J. W. M., & Muller, R. (01 January 2002). Dy-DTPA derivatives as relaxation agents for very high field MRI: the beneficial effect of a slow water exchange. Magnetic Resonance in Medicine, 47, 1121-1130.
Peer Reviewed verified by ORBi

Gossuin, Y., Roch, A., Muller, R., & Gillis, P. (08 December 2001). Relaxation Induced by Ferritin and Ferritin-Like Magnetic Particles: The Role of Proton Exchange. Magnetic Resonance in Medicine, 43, 237-243.
Peer Reviewed verified by ORBi

Gossuin, Y., Roch, A., Lo Bue, F., Muller, R., & Gillis, P. (08 July 2001). Nuclear Magnetic Relaxation Dispersion of Ferritin and Ferritin-Like Magnetic Particle Solutions: A pH-Effect Study. Magnetic Resonance in Medicine, 46, 476-481.
Peer Reviewed verified by ORBi

Roch, A., Muller, R., & Gillis, P. (31 March 1999). Theory of proton relaxation induced by superparamagnetic particles. Journal of Chemical Physics, 110 (11), 5403-5411.
Peer Reviewed verified by ORBi

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