Profil

Villers Agnès

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Neurosciences

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Neurosciences


Main Research Fields
Neurology
General & internal medicine
Biochemistry, biophysics & molecular biology
Chemistry
Endocrinology, metabolism & nutrition
Main Keywords
Cytokines; General Medicine; alpha-CaMKII; Alzheimer Disease/drug therapy; Alzheimer’s disease;
Main Unit & Research Centers
CIPSE - Centre de recherche interdisciplinaire en Psychophysiologie et Electrophysiologie de la cognition
CREMH - Mind & Health
UMHAP - Centre de Recherche UMONS-Ambroise Paré
Main Co-authors
Ris, Laurence 
RIS, Laurence 
Colet, Jean-Marie 
Gloire, Mélanie 

Publications (total 58)

The most downloaded
9 downloads
Verbruggen, L., Ates, G., Lara, O., De Munck, J., Villers, A., De Pauw, L., Ottestad-Hansen, S., Kobayashi, S., Beckers, P., Janssen, P., Sato, H., Zhou, Y., Hermans, E., Njemini, R., Arckens, L., Danbolt, N. C., De Bundel, D., Aerts, J., Barbé, K., & Massie, A. (01 February 2022). Lifespan extension with preservation of hippocampal function in aged system xc- deficient male mice. Molecular Psychiatry, Feb18. https://hdl.handle.net/20.500.12907/4308
The most cited
97 citations (Scopus®)
Stancu, I.-C., Vasconcelos, B., Ris, L., Wang, P., Villers, A., Peeraer, E., Buist, A., Terwel, D., Baatsen, P., Oyelami, T., Pierrot, N., Casteels, C., Bormans, G., Kielen-Campard, P., Octave, J.-N., Moechars, D., & Dewachter, I. (01 June 2015). Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathologica, 129 (6), 875-94. doi:10.1007/s00401-015-1413-4 https://hdl.handle.net/20.500.12907/33875

Targa, G., Caffino, L., Villers, A., Mottarlini, F., Lovera, A., Gainetdinov, R. R., Ris, L., Fumagalli, F., & Leo, D. (30 September 2022). Dopamine Transporter Knock‐out Rats (DAT KO) as an innovative animal model for Dopamine Transporter Deficiency Syndrome. Paper presented at Conference on rare neurotransmitter diseases, Belgrade, Serbia.

Delpierre, A., Deroux, C., Ris, L., Decleves, A.-E., Legrand, A., Villers, A., & Tassin, A. (12 September 2022). Focus on the endocrine function of skeletal muscle: study of muscle-to-brain communication under voluntary and forced exercise applied in the context of obesity in mice. Poster session presented at 7th International scientific congress "Myology 2022", Nice, France.

Leo, D., Targa, G., Espinoza, S., Villers, A., Gainetdinov, R. R., & Ris, L. (15 July 2022). Trace Amine Associate Receptor 1 (TAAR1) as a New Target for the Treatment of Cognitive Dysfunction in Alzheimer's Disease. International Journal of Molecular Sciences, 23 (14), 7811. doi:10.3390/ijms23147811
Peer Reviewed verified by ORBi

Targa, G., Caffino, L., Villers, A., Mottarlini, F., Lovera, A., Gainetdinov Raul, Ris, L., Leo, D., & Fumagalli, F. (11 July 2022). Deletion of the Dopamine Transporteur depotentiates the glutamatergic neurotransmission in the rat striatum. Poster session presented at FENS Forum 2022, Paris, France.

Villers, A., Espinoza, S., Dermine, E., Targa, G., Ris, L., Gainetdinov, R., & Leo, D. (29 May 2022). Dopamine Transporter Knock-out Rats an innovative animal model for dopamine related diseases. Xjenza Online, 10.
Editorial reviewed

Verbruggen, L., Ates, G., Lara, O., De Munck, J., Villers, A., De Pauw, L., Ottestad-Hansen, S., Kobayashi, S., Beckers, P., Janssen, P., Sato, H., Zhou, Y., Hermans, E., Njemini, R., Arckens, L., Danbolt, N. C., De Bundel, D., Aerts, J., Barbé, K., & Massie, A. (01 February 2022). Lifespan extension with preservation of hippocampal function in aged system xc- deficient male mice. Molecular Psychiatry, Feb18.
Peer Reviewed verified by ORBi

Decarnoncle, M., Decroo, C., Coppée, F., Tassin, A., Tagliatti, V., Villers, A., Colet, J.-M., Nonclercq, D., Legrand, A., Ris, L., Wattiez, R., & Decleves, A.-E. (25 November 2021). Développement d'une trousse de dosage d'organokines par spectrométrie de masse. Poster session presented at Networking EpiCURA-UMONS, Baudour, Belgium.

Lantoine, J., Proces, A., Villers, A., Halliez, S., Buée, L., Ris, L., & Gabriele, S. (2021). Inflammatory Molecules Released by Mechanically Injured Astrocytes Trigger Presynaptic Loss in Cortical Neuronal Networks. ACS Chemical Neurosciences. doi:10.1021/acschemneuro.1c00488f
Peer Reviewed verified by ORBi

Bentea, E., Villers, A., Moore, C., Funk, A. J., O'Donovan, S. M., Verbruggen, L., Lara, O., Janssen, P., De Pauw, L., Declerck, N. B., DePasquale, E. A., Churchill, M. J., Sato, H., Hermans, E., Arckens, L., Meshul, C. K., Ris, L., McCullumsmith, R. E., & Massie, A. (26 September 2021). Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter. Molecular Psychiatry, Sep 26 (9), 1-16. doi:10.1038/s41380-020-0751-3
Peer Reviewed verified by ORBi

Delpierre, A., Deroux, C., Ris, L., Decleves, A.-E., Legrand, A., Villers, A., & Tassin, A. (25 May 2021). Muscle-to-Brain communication in the context of obesity: impact of physical exercise? Paper presented at PhysPhar Spring meeting, Belgium.

Delpierre, A., Akan, M., Deroux, C., Jenart, V., Ris, L., Decleves, A.-E., Legrand, A., Villers, A., & Tassin, A. (30 March 2021). Effect of voluntary and forced exercise on FNDC5-Irisin pathway and muscle-to-brain crosstalk in a model of obesity. Poster session presented at Mardi des chercheurs, Valenciennes, France.

Leo, D., Espinoza, S., Villers, A., Gainetdinov, R., & Ris, L. (11 July 2020). Trace amine associate receptor 1 (TAAR1) as a new target for the treatment of cognitive dysfunction in Alzheimer disease. Poster session presented at 12 FENS, Glasgow, United Kingdom.

Leo, D., Espinoza, S., Villers, A., Gainetdinov, R., & Ris, L. (2019). Trace amine associate receptor 1 (TAAR1) as a new target for the treatment of cognitive dysfunction in Alzheimer disease. Paper presented at 32nd European college of neuropsychopharmacology congress, Copenhagen, Denmark.

Delpierre, A., Villers, A., Deroux, C., Ris, L., Decleves, A.-E., Legrand, A., & Tassin, A. (22 November 2019). Muscle-to-brain communication in the context of obesity : impact of physical exercise. Poster session presented at Physphar Autumn Meeting, Bruxelles , Unknown/unspecified.

Verbruggen, L., Bentea, E., Villers, A., Olaya, L., Gamze, A., De Bundel, D., Hideyo, S., Ris, L., & Massie, A. (24 May 2019). System xc- deficiency extends life-span and prevents age-related hippocampal dysfunction in mice. Paper presented at 13th National Congress of the Belgian Society for Neuroscience, Brussels, Belgium.

Delcourt, M., Delpierre, A., Tassin, A., Colet, J.-M., Decleves, A.-E., & Villers, A. (2019). L'obésité a encore frappé - Le fumarate et son rôle au sein du tissu adipeux.

Leo, D., Espinoza, S., Villers, A., Gainetdinov, R., & Ris, L. (24 May 2019). Trace amine associate receptor 1 (TAAR1) as a new target for the treatment of cognitive dysfunction in Alzheimer disease. Paper presented at 13th National Congress of the Belgian Society for Neuroscience, Brussels, Belgium.

Delpierre, A., Villers, A., Deroux, C., Ris, L., Decleves, A.-E., Legrand, A., & Tassin, A. (05 March 2019). Inter-communication muscle - cerveau dans un contexte d'obésité : Impact de l'exercice. Poster session presented at Mardi des Chercheurs 2019 (MdC2019), Mons, Belgium.

Massie, A., Bentea, E., Villers, A., Moore, C., Funk, A., O'Donovan, S. M., Verbruggen, L., Depasquale, E., Churchill, M. J., Sato, H., Ris, L., Meshul, C. K., & McCullumsmith, R. E. (07 November 2018). The cystine/glutamate antiporter system xc- as modulator of corticostriatal neurotransmission. Paper presented at Neuroscience 2018, San Diego, United States - California.

Proces, A., Villers, A., Gabriele, S., & Ris, L. (20 September 2018). Development of an experimental model of traumatic brain injury using hippocampal slice cultures. Poster session presented at BSCDB and RBSM meeting: Cell and Tissue Mechanics in Physiology and Disease, Antwerpen, Belgium. doi:10.1088/1748-0221/5/03/T03013

Bentea, E., Moore, C., Villers, A., Churchill, M. J., Hood, R. L., Deneyer, L., Verbruggen, L., Albertini, G., Sato, H., Ris, L., Meshul, C., & Massie, A. (01 April 2018). System xc- as a novel modulator of corticostriatal neurotransmission. Paper presented at Crossing Borders in Schizotypy Research, Bejing, China.

Ris, L., Villers, A., & Gloire, M. (08 September 2017). Alzheimer and Brain metabolism: what is the role of Amyloid Precursor Protein? Paper presented at Innovations and State of the Art in Dementia Research, Roma, Italy.

Rinchon, A., Villers, A., & Ris, L. (22 May 2017). The hippocampus during EAE: the impact of neuroinflammation and the influence of gender on immune responses. Paper presented at 12th National Congress of the Belgian Society for Neuroscience, Ghent, Ughent, Belgium.

Gloire, M., Villers, A., Colet, J.-M., & Ris, L. (30 March 2017). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Poster session presented at The 13th International conference on Alzheimer's and Parkinson's diseases, Vienne, Austria.

Gloire, M., Villers, A., Colet, J.-M., & Ris, L. (30 March 2017). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Paper presented at The 13th International conference on Alzheimer's and Parkinson's diseases, Vienne, Austria.

Rinchon, A., Villers, A., & Ris, L. (07 March 2017). Neuroinflammatory processes induced during EAE also affect the hippocampus and its associated cognitive processes. Poster session presented at Huitième édition montoise du MdC : le Mardi des Chercheurs 2017, UMons, Belgium.

Gloire, M., Villers, A., Colet, J.-M., & Ris, L. (07 March 2017). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Poster session presented at Huitième édition montoise du MdC : le Mardi des Chercheurs 2017, UMons, Belgium.

Lantoine, J., Villers, A., Gabriele, S., & Ris, L. (04 December 2016). Microprinted neuronal networks as an efficient platform for studying the role of cytokines on neuronal plasticity. Paper presented at American Society for Cell Biology, San Francisco, United States - California.

Rinchon, A., Villers, A., & Ris, L. (28 November 2016). Neuroinflammatory processes induced during EAE also affect the hippocampus and its associated cognitive processes. Poster session presented at Biological and bio-inspired adhesion meeting, Research Institute for Biosciences (UMONS), Mons, Belgium.

Gloire, M., Villers, A., Colet, J.-M., & Ris, L. (28 November 2016). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Poster session presented at Biological and bio-inspired adhesion meeting, Research Institute for Biosciences (UMONS), Mons, Belgium.

Lantoine, J., Villers, A., Ris, L., & Gabriele, S. (07 November 2016). Microprinted neuronal networks as an efficient platform for studying the role of cytokines on neuronal plasticity. Poster session presented at GDR Physique de la Cellule aux Tissus, Arcachon, France.

Rinchon, A., Villers, A., & Ris, L. (08 October 2016). Neuroinflammatory processes induced during EAE also affect the hippocampus and its associated cognitive processes. Paper presented at Belgian Brain Congress, MICX. October 8, 2016, Mons, Belgium.

Gloire, M., Villers, A., Colet, J.-M., & Ris, L. (08 October 2016). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Paper presented at 6th Belgian Brain Congress, Mons, Belgium.

Rinchon, A., Villers, A., & Ris, L. (08 October 2016). Neuroinflammatory processes induced during EAE also affect the hippocampus and its associated cognitive processes. Poster session presented at 6th Belgian Brain Congress, Mons, Belgium.

Jensen, C., Demol, F., Bauwens, R., Kooijman, R., Massie, A., Villers, A., Ris, L., & Dekeyser, J. (04 October 2016). Astrocytic β2 adrenergic receptor gene deletion affects memory in aged mice. PLoS ONE, PONE-D-16-11141R1.
Peer reviewed

Rinchon, A., Villers, A., & Ris, L. (05 July 2016). Neuroinflammation and hippocampal synaptic plasticity during experimental autoimmune encephalomyelitis. Paper presented at 10th FENS Forum of Neuroscience, Copenhagen, Denmark.

Gloire, M., Colet, J.-M., Villers, A., & Ris, L. (03 July 2016). Reciprocal influence between APP expression and glucose metabolism in the hippocampus. Poster session presented at 10th FENS Forum of Neuroscience, Copenhagen, Denmark.

Rinchon, A., Villers, A., & Ris, L. (25 March 2016). Impact of neuroinflammation developed during EAE on hippocampal synaptic plasticity and cognition. Poster session presented at FWO Symposium on Multiple Sclerosis, Gand, Belgium.

Lantoine, J., Grevesse, T., Villers, A., Delhaye, G., Versaevel, M., Mohammed, D., Bruyere, C., Alaimo, L., Lacour, S., Ris, L., & Gabriele, S. (26 February 2016). Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures. Biomaterials, 89, 14-24.
Peer Reviewed verified by ORBi

Gloire, M., Villers, A., & Ris, L. (23 June 2015). Relationship linking glucose metabolism to Amyloid Precursor Protein expression and processing. Paper presented at The 2015 Alzheimer's disease congress, London, United Kingdom.

Stancu, I.-C., Vasconcelos, B., Ris, L., Wang, P., Villers, A., Peeraer, E., Buist, A., Terwel, D., Baatsen, P., Oyelami, T., Pierrot, N., Casteels, C., Bormans, G., Kielen-Campard, P., Octave, J.-N., Moechars, D., & Dewachter, I. (01 June 2015). Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathologica, 129 (6), 875-94. doi:10.1007/s00401-015-1413-4
Peer Reviewed verified by ORBi

Rinchon, A., Brunois, C., Villers, A., & Ris, L. (22 May 2015). Hippocampal synaptic plasticity and neuroinflammation during the course of experimental autoimmune encephalomyelitis. Paper presented at 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium.

Abbas, A. K., Villers, A., & Ris, L. (2015). The temporal phases of long-term potentiation (LTP) : myth or fact? Reviews in the Neurosciences. doi:10.1515/revneuro-2014-0072
Peer Reviewed verified by ORBi

Gloire, M., Villers, A., & Ris, L. (29 April 2015). Study of the physiopathological roles of APP: implication in Alzheimer's disease and type 2 diabetes. Paper presented at 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium.

Villers, A., Giese, K. P., & Ris, L. (20 October 2014). Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation. Learning and Memory, 21 (11), 616-626. doi:10.1101/lm.035972.114
Peer Reviewed verified by ORBi

Villers, A. (2013). Study of the Mechanisms of Long Term Potentiation: Reconsideration of the Role of Protein Synthesis. Eprint/Working paper retrieved from https://orbi.umons.ac.be/20.500.12907/8520.

Villers, A., & Ris, L. (06 June 2013). Improved preparation and preservation of hippocampal mouse slices for a very stable and reproducible recording of long term potentiation. Journal of Visualized Experiments, 76 (e50483). doi:10.3791/50483
Peer reviewed

Villers, A., Lucchesi, W., Giese, K. P., & Ris, L. (18 April 2013). L-LTP can be induced in CA1 pyramidal cells in the absence of alpha-CaMKII autophosphorylation. Paper presented at 1st European Neuroscience Conference by Doctoral Students, Bordeaux, France.

Villers, A. (2013). Etude des mécanismes de la potentialisation à long terme : reconsidération du rôle de la synthèse des protéines. Unpublished doctoral thesis, Université de Mons.
Jury: Ris, L. (Promotor), Capron, B., Nonclercq, D., Schiffmann, S., Seutin, V., & Wattiez, R.

Villers, A., Lucchesi, W., Giese, K. P., & Ris, L. (14 July 2012). L-LTP can be induced in CA1 pyramidal cells in the absence of alpha-CaMKII autophosphorylation but with a loss of specificity. Paper presented at 8th FENS Forum of Neuroscience, Barcelona, Spain.

Villers, A., Godaux, E., & Ris, L. (11 July 2012). Long-Lasting LTP Requires Neither Repeated Trains for Its Induction Nor Protein Synthesis for Its Development. PLoS ONE, 7 (7), 1-12.
Peer reviewed

Radwanska, K., Medvedev, N., Pereira, G. S., Engmann, O., Thiede, N., Moraes, M. F. D., Villers, A., Irvine, E. E., Maunganidze, N. S., Pyza, E. M., Ris, L., Szymanska, M., Lipinski, M., Kaczmarek, L., Stewart, M. G., & Giese, K. P. (08 November 2011). Mechanism for long-term memory formation when synaptic strengthening is impaired. Proceedings of the National Academy of Sciences of the United States of America, 108 (45), 18471-18475.
Peer Reviewed verified by ORBi

Villers, A., Godaux, E., & Ris, L. (23 May 2011). An L-LTP independent of de novo protein synthesis can be induced by a single train in hippocampal slices. Paper presented at 9th Bi-Annual Meeting of the Belgian Society for Neuroscience, Leuven, Belgium.

Villers, A., Godaux, E., & Ris, L. (18 March 2011). L-LTP can be induced by a single train of stimulation in presence of protein-synthesis inhibitors. Paper presented at PhysPhar, Liège, Belgium.

Villers, A., Godaux, E., & Ris, L. (05 July 2010). Proteins synthesized in dendrites can sustain local long-lasting long term potentiation (L-LTP) but cannot be captured by other synapses. Paper presented at 7th Forum of Neuroscience, Amsterdam, Netherlands.

Villers, A., Godaux, E., & Ris, L. (17 February 2010). Late phase of L-LTP elicited in isolated CA1 dendrites cannot be transferred by synaptic capture. Neuroreport, 21, 210-205.
Peer Reviewed verified by ORBi

Ris, L., Villers, A., & Godaux, E. (01 November 2009). Synaptic capture-mediated L-LTP is strongly dependent on mRNA translation. Neuroreport, 20, 1572-1576.
Peer Reviewed verified by ORBi

Villers, A., Godaux, E., & Ris, L. (11 May 2009). Protein synthesis in dendrites plays an important role in long-lasting long-term potentiation (L-LTP). Paper presented at 8th Bi-Annual Meeting of the Belgian Society for Neuroscience, Liège, Belgium.

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