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Wells Mathilde

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service d'Analyse pharmaceutique

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Analyse pharmaceutique

Main Referenced Co-authors
BLANKERT, Bertrand  (28)
Hambye, Stéphanie  (22)
Lenaerts, Charline  (5)
Soumoy, Laura  (5)
JOURNE, Fabrice  (4)
Main Referenced Keywords
malaria (6); toad (4); Toad venom (4); venom (4); Antiplasmodial (3);
Main Referenced Unit & Research Centers
CISMA - Centre Interdisciplinaire de Spectrométrie de Masse (4)
UMHAP - Centre de Recherche UMONS-Ambroise Paré (2)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (28)
Chemical engineering (15)
Chemistry (14)
Oncology (2)
Biochemistry, biophysics & molecular biology (2)

Publications (total 34)

The most downloaded
27 downloads
Wells, M., Fossepre, M., Hambye, S., Surin, M., & Blankert, B. (December 2022). Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process. International Journal for Parasitology: Drugs and Drug Resistance, 20, 97 - 107. doi:10.1016/j.ijpddr.2022.10.001 https://hdl.handle.net/20.500.12907/44247

The most cited

13 citations (Scopus®)

Loyez, M., Wells, M., Hambye, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (28 July 2021). PfHRP2 detection using plasmonic optrodes: performance analysis. Malaria Journal, 20 (332). https://hdl.handle.net/20.500.12907/7677

Delcorps, J., Ben ayed, A., Wells, M., Gerbaux, P., & Coulembier, O.*. (26 January 2024). Preparation of Dialkyl Carbonates through Unique Guanidinium-assisted SN2 Ion-Pair Process [Paper presentation]. EDT-CHIM Scientific Day.

Soumoy, L., Genbauffe, A., Mouchart, L., Sperone, A., Trelcat, A., Mukeba-Harchies, L., Wells, M., Blankert, B., Najem, A., Ghanem, G., Saussez, S., & Journe, F. (04 January 2024). ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy. Cancer Cell International, 24 (1), 8. doi:10.1186/s12935-023-03196-y
Peer Reviewed verified by ORBi

Wells, M., Hambye, S., & Blankert, B. (24 May 2023). Du venin de crapaud aux composés antiplasmodiaux en un bond : Stratégies de fractionnement bio-guidé par chromatographie flash et CCM préparative [Paper presentation]. Journée AFSEP Club Île de France - Prep, partez ! Le point sur la chromatographie préparative, Paris, France.

Wells, M., Hambye, S., & Blankert, B. (2023). Preliminary insight into the potential antiplasmodial activity and cytotoxicity of Bufo bufo and Incilius alvarius poison. Toxicon, 227. doi:10.1016/j.toxicon.2023.107092
Peer Reviewed verified by ORBi

Wells, M., Fossepre, M., Hambye, S., Surin, M., & Blankert, B. (December 2022). Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process. International Journal for Parasitology: Drugs and Drug Resistance, 20, 97 - 107. doi:10.1016/j.ijpddr.2022.10.001
Peer Reviewed verified by ORBi

Wells, M., Hambye, S., & Blankert, B. (12 September 2022). Development of a bioassay-guided fractionation protocol to unveil toad venoms as a new source of potential antimalarial candidates [Paper presentation]. 12th International Symposium of Drug Analysis 32nd International Symposium on Pharmaceutical and Biomedical Analysis, Mons, Belgium.
Peer reviewed

Soumoy, L., Wells, M., Najem, A., Krayem, M., Ghanem, G., Hambye, S., Saussez, S., Blankert, B., & Journe, F. (12 September 2022). Uncovering the antiproliferative potential of toad venoms on metastatic melanoma [Poster presentation]. 12th International Symposium of Drug Analysis 32nd International Symposium on Pharmaceutical and Biomedical Analysis, Mons, Belgium.
Peer reviewed

Wells, M. (2022). Development of a bioassay-guided fractionation protocol to unveil toad venoms as a new source of potential antimalarial candidates [Doctoral thesis, UMONS - Université de Mons]. ORBi UMONS-University of Mons. https://orbi.umons.ac.be/handle/20.500.12907/44317

Loyez, M., Wells, M., Hambÿe, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (17 May 2022). PfHRP2 detection using plasmonic optical fibers: a step towards early malaria diagnosis. Proceedings of SPIE: The International Society for Optical Engineering, 12139.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (05 October 2021). Développement d'une stratégie de fractionnement bio-guidé pour l'identification de composés antiplasmodiaux issus de venins de Bufonidae [Poster presentation]. 14ème Congrès Francophone sur les Sciences Séparatives et les Couplages de l'AFSEP, Paris, France.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (14 September 2021). Identifying new potential antimalarial compound in toad venoms through a bio-guided fractionation process [Paper presentation]. 1st Congress of the European Venom Network EUVEN.
Peer reviewed

Loyez, M., Wells, M., Hambye, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (28 July 2021). PfHRP2 detection using plasmonic optrodes: performance analysis. Malaria Journal, 20 (332).
Peer reviewed

Van Bourgogne, N., Wells, M., Hambye, S., & Blankert, B. (2021). Activité cytostatique et antiproliférative de composés de bas poids moléculaire issus de venins [Master’s dissertation, Université de Mons]. ORBi UMONS-University of Mons. https://orbi.umons.ac.be/handle/20.500.12907/8343

Wells, M., Hambye, S., & Blankert, B. (17 September 2020). Discovery strategies for novel antiplasmodial compounds from the venom of Bufo toads [Paper presentation]. Venoms and Toxins, Oxford, United Kingdom.
Peer reviewed

Soumoy, L., Wells, M., Ahmad, N., Krayem, M., Ghanem, G., Hambye, S., Saussez, S., Blankert, B., & Journe, F. (2020). 'Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms'. Biology, (9), 218-234.
Peer reviewed

Wells, M., & Soumoy, L. (03 February 2020). Évaluation in vitro des activités antiprolifératives et cytotoxiques d'extraits de venins de crapauds sur des lignées cellulaires de mélanome [Paper presentation]. Séminaire 'Kangourou' de l'Institut Santé, Mons, Belgium.

Wells, M., Soumoy, L., Journe, F., Saussez, S., Hambye, S., & Blankert, B. (04 December 2019). Bio-guided fractionation for the isolation of antiplasmodial and cytotoxic compounds from the venom of Bufo toads [Paper presentation]. 26ème RT-SFET, Paris, France.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (29 November 2019). Fractionation process for the isolation of antiplasmodial compounds from the venom of Rhinella marina and Bufo bufo [Poster presentation]. Bioforum, Liège, Belgium.

Baroni, A., Neaga, I., Delbosc, N., Wells, M., Verdy, L., Ansseau, E., Vanden Eynde, J.-J., Belayew, A., Bodoki, E., Oprean, R., Hambye, S., & Blankert, B. (25 September 2019). Bioactive Aliphatic Polycarbonates Carrying Guanidinium Functions: An Innovative Approach for Myotonic Dystrophy Type 1 Therapy. ACS Omega, 4 (19), 18126 - 18135. doi:10.1021/acsomega.9b02034
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (2019). Du venin de crapaud pour soigner la malaria. La Province.

Wells, M. (24 May 2019). Draw my PhD [Paper presentation]. Journée de l'institut santé, Mons, Belgium.

Wells, M., Van Koninckxloo-Van Bever, A., Hambye, S., & Blankert, B. (20 May 2019). Extraction and characterization of potential new antimalarial compounds from toad venom [Paper presentation]. 20th Forum of Pharmaceutical Sciences, Brussels, Belgium.

Wells, M., Van Koninckxloo-Van Bever, A., Hambye, S., & Blankert, B. (05 March 2019). Analysis and comparison of bufadienolide contents in the venoms of six different species of Bufo toads by High-Performance Thin-layer Chromatography [Poster presentation]. Matinée des chercheurs (MdC 2019), Mons, Belgium.

Lenaerts, C., Wells, M., Hambye, S., & Blankert, B. (17 January 2019). Marinobufagenin extraction from Rhinella marina toad glands: alternative approaches for a systematized strategy. Journal of Separation Science, 42 (7), 1384 - 1392. doi:10.1002/jssc.201800879
Peer Reviewed verified by ORBi

Lenaerts, C., Wells, M., Hambye, S., & Blankert, B. (12 September 2018). Quantification of endogenous marinobufagin by a high-specific and very sensitive UPLC-MS/MS assay in non-patological pregnancy and preeclampsia [Paper presentation]. DA-PBA 2018 : 11th International symposium on Drug Analysis - 29th International Symposium on Pharmaceutical and Biomedical Analysis, Leuven, Belgium.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (10 September 2018). Extraction and characterization of potential new antimalarial compounds from toads' venoms [Poster presentation]. DA-PBA 2018 : 11th International symposium on Drug Analysis - 29th International Symposium on Pharmaceutical and Biomedical Analysis, Leuven, Belgium.

Thi Nguyen, B.-L., Wells, M., Nachtergael, A., & Duez, P. (26 August 2018). Cytotoxicity study of Equisetum diffusum D. Don., Glochidion eriocarpum Champ. ex Benth., Clerodendrum cyrtophyllum Turcz. collected in Northern Vietnam [Poster presentation]. 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Shanghai, China.

Wells, M., Hambye, S., & Blankert, B. (12 July 2018). Isolation and identification strategies of potential antimalarial components from toad venom (bufo marinus) using thin-layer chromatography [Poster presentation]. 2nd International Symposium on Advances in Pharmaceutical Analysis, Lille, France.

Lepoutte, P., Blankert, B., & Wells, M. (2018). Le laboratoire frasnois Alphabiotoxine est renommé dans le monde entier. L'Avenir.

Wells, M. (15 May 2018). Extraction et caractérisation de nouveaux agents anti-malariques potentiels du venin de crapauds [Paper presentation]. 1er Congrès PerScif - La parole aux jeunes chercheurs en FMP, Mons, Belgium.

Wells, M., Hambye, S., & Blankert, B. (27 March 2018). Isolation strategies of potential antiplasmodial compounds from Bufo toad venom [Poster presentation]. Mardi des Chercheurs (MdC2018), Valenciennes, France.

Wells, M., Lenaerts, C., & Blankert, B. (2017). Amélioration des techniques d'extraction de la marinobufagénine de matrices complexes [Master’s dissertation, Université de Mons]. ORBi UMONS-University of Mons. https://orbi.umons.ac.be/handle/20.500.12907/9996

Wells, M., Lenaerts, C., Hambye, S., & Blankert, B. (28 March 2017). Stratégies d'extraction et de purification de la Marinobufagénine à partir du venin du crapaud Bufo marinus [Poster presentation]. 12ème Congrès de l'Association Francophone des Sciences Séparatives, Paris, France.

Wells, M., Lenaerts, C., & Blankert, B. (2016). Exploration et perfectionnement des techniques de purification de la Marinobufagénine à partir du venin de Bufo Marinus.

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