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Wells Mathilde

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service d'Analyse pharmaceutique

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Analyse pharmaceutique


Main Referenced Co-authors
BLANKERT, Bertrand  (25)
Hambye, Stéphanie  (20)
Lenaerts, Charline  (5)
Soumoy, Laura  (4)
Journe, Fabrice  (3)
Main Referenced Keywords
malaria (5); toad (4); Toad venom (4); venom (4); Antiplasmodial (3);
Main Referenced Unit & Research Centers
CISMA - Centre Interdisciplinaire de Spectrométrie de Masse (4)
UMHAP - Centre de Recherche UMONS-Ambroise Paré (2)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (26)
Chemical engineering (15)
Chemistry (12)
Biochemistry, biophysics & molecular biology (2)
Oncology (1)

Publications (total 30)

The most downloaded
7 downloads
Lenaerts, C., Wells, M., Hambye, S., & Blankert, B. (17 January 2019). Marinobufagenin extraction from Rhinella marina toad glands: alternative approaches for a systematized strategy. Journal of Separation Science, 42 (7), 1384 - 1392. doi:10.1002/jssc.201800879 https://hdl.handle.net/20.500.12907/36627
The most cited
8 citations (Scopus®)
Loyez, M., Wells, M., Hambye, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (28 July 2021). PfHRP2 detection using plasmonic optrodes: performance analysis. Malaria Journal, 20 (332). https://hdl.handle.net/20.500.12907/7677

Wells, M., Fossepre, M., Hambye, S., Surin, M., & Blankert, B. (December 2022). Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process. International Journal for Parasitology: Drugs and Drug Resistance, 20, 97 - 107. doi:10.1016/j.ijpddr.2022.10.001
Peer Reviewed verified by ORBi

Soumoy, L., Wells, M., Najem, A., Krayem, M., Ghanem, G., Hambye, S., Saussez, S., Blankert, B., & Journe, F. (12 September 2022). Uncovering the antiproliferative potential of toad venoms on metastatic melanoma. Poster session presented at 12th International Symposium of Drug Analysis 32nd International Symposium on Pharmaceutical and Biomedical Analysis, Mons, Belgium.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (12 September 2022). Development of a bioassay-guided fractionation protocol to unveil toad venoms as a new source of potential antimalarial candidates. Paper presented at 12th International Symposium of Drug Analysis 32nd International Symposium on Pharmaceutical and Biomedical Analysis, Mons, Belgium.
Peer reviewed

Wells, M. (2022). Development of a bioassay-guided fractionation protocol to unveil toad venoms as a new source of potential antimalarial candidates. Unpublished doctoral thesis, UMONS - Université de Mons [Faculté de Médecine et de Pharmacie], Mons, Belgium.
Jury: Blankert, B. (Promotor), Dufrasne, F., Duez, P., Gerbaux, P., Delporte, C., Violette, A., & Hambye, S.

Loyez, M., Wells, M., Hambÿe, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (05 April 2022). PfHRP2 detection using plasmonic optical fibers: a step towards early malaria diagnosis. Paper presented at SPIE Photonics Europe 2022, Strasbourg, France.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (05 October 2021). Développement d'une stratégie de fractionnement bio-guidé pour l'identification de composés antiplasmodiaux issus de venins de Bufonidae. Poster session presented at 14ème Congrès Francophone sur les Sciences Séparatives et les Couplages de l'AFSEP, Paris, France.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (14 September 2021). Identifying new potential antimalarial compound in toad venoms through a bio-guided fractionation process. Paper presented at 1st Congress of the European Venom Network EUVEN.
Peer reviewed

Loyez, M., Wells, M., Hambye, S., Hubinon, F., Blankert, B., Wattiez, R., & Caucheteur, C. (28 July 2021). PfHRP2 detection using plasmonic optrodes: performance analysis. Malaria Journal, 20 (332).
Peer reviewed

Van Bourgogne, N., Wells, M., Hambye, S., & Blankert, B. (2021). Activité cytostatique et antiproliférative de composés de bas poids moléculaire issus de venins. Unpublished master thesis, Université de Mons.
Jury: Blankert, B. (Promotor), Hambye, S. (Promotor), & Wells, M. (Promotor).

Wells, M., Hambye, S., & Blankert, B. (17 September 2020). Discovery strategies for novel antiplasmodial compounds from the venom of Bufo toads. Paper presented at Venoms and Toxins, Oxford, United Kingdom.
Peer reviewed

Soumoy, L., Wells, M., Ahmad, N., Krayem, M., Ghanem, G., Hambye, S., Saussez, S., Blankert, B., & Journe, F. (2020). 'Toad Venom Antiproliferative Activities on Metastatic Melanoma: Bio-Guided Fractionation and Screening of the Compounds of Two Different Venoms'. Biology, (9), 218-234.
Peer reviewed

Wells, M., & Soumoy, L. (03 February 2020). Évaluation in vitro des activités antiprolifératives et cytotoxiques d'extraits de venins de crapauds sur des lignées cellulaires de mélanome. Paper presented at Séminaire 'Kangourou' de l'Institut Santé, Mons, Belgium.

Wells, M., Soumoy, L., Journe, F., Saussez, S., Hambye, S., & Blankert, B. (04 December 2019). Bio-guided fractionation for the isolation of antiplasmodial and cytotoxic compounds from the venom of Bufo toads. Paper presented at 26ème RT-SFET, Paris, France.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (29 November 2019). Fractionation process for the isolation of antiplasmodial compounds from the venom of Rhinella marina and Bufo bufo. Poster session presented at Bioforum, Liège, Belgium.

Baroni, A., Neaga, I., Delbosc, N., Wells, M., Verdy, L., Ansseau, E., Vanden Eynde, J.-J., Belayew, A., Bodoki, E., Oprean, R., Hambye, S., & Blankert, B. (25 September 2019). Bioactive Aliphatic Polycarbonates Carrying Guanidinium Functions: An Innovative Approach for Myotonic Dystrophy Type 1 Therapy. ACS Omega, 4 (19), 18126 - 18135. doi:10.1021/acsomega.9b02034
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (2019). Du venin de crapaud pour soigner la malaria. La Province.

Wells, M. (24 May 2019). Draw my PhD. Paper presented at Journée de l'institut santé, Mons, Belgium.

Wells, M., Van Koninckxloo-Van Bever, A., Hambye, S., & Blankert, B. (20 May 2019). Extraction and characterization of potential new antimalarial compounds from toad venom. Paper presented at 20th Forum of Pharmaceutical Sciences, Brussels, Belgium.

Wells, M., Van Koninckxloo-Van Bever, A., Hambye, S., & Blankert, B. (05 March 2019). Analysis and comparison of bufadienolide contents in the venoms of six different species of Bufo toads by High-Performance Thin-layer Chromatography. Poster session presented at Matinée des chercheurs (MdC 2019), Mons, Belgium.

Lenaerts, C., Wells, M., Hambye, S., & Blankert, B. (17 January 2019). Marinobufagenin extraction from Rhinella marina toad glands: alternative approaches for a systematized strategy. Journal of Separation Science, 42 (7), 1384 - 1392. doi:10.1002/jssc.201800879
Peer Reviewed verified by ORBi

Lenaerts, C., Wells, M., Hambye, S., & Blankert, B. (12 September 2018). Quantification of endogenous marinobufagin by a high-specific and very sensitive UPLC-MS/MS assay in non-patological pregnancy and preeclampsia. Paper presented at DA-PBA 2018 : 11th International symposium on Drug Analysis - 29th International Symposium on Pharmaceutical and Biomedical Analysis, Leuven, Belgium.
Peer reviewed

Wells, M., Hambye, S., & Blankert, B. (10 September 2018). Extraction and characterization of potential new antimalarial compounds from toads' venoms. Poster session presented at DA-PBA 2018 : 11th International symposium on Drug Analysis - 29th International Symposium on Pharmaceutical and Biomedical Analysis, Leuven, Belgium.

Thi Nguyen, B.-L., Wells, M., Nachtergael, A., & Duez, P. (26 August 2018). Cytotoxicity study of Equisetum diffusum D. Don., Glochidion eriocarpum Champ. ex Benth., Clerodendrum cyrtophyllum Turcz. collected in Northern Vietnam. Poster session presented at 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Shanghai, China.

Wells, M., Hambye, S., & Blankert, B. (12 July 2018). Isolation and identification strategies of potential antimalarial components from toad venom (bufo marinus) using thin-layer chromatography. Poster session presented at 2nd International Symposium on Advances in Pharmaceutical Analysis, Lille, France.

Lepoutte, P., Blankert, B., & Wells, M. (2018). Le laboratoire frasnois Alphabiotoxine est renommé dans le monde entier. L'Avenir.

Wells, M. (15 May 2018). Extraction et caractérisation de nouveaux agents anti-malariques potentiels du venin de crapauds. Paper presented at 1er Congrès PerScif - La parole aux jeunes chercheurs en FMP, Mons, Belgium.

Wells, M., Hambye, S., & Blankert, B. (27 March 2018). Isolation strategies of potential antiplasmodial compounds from Bufo toad venom. Poster session presented at Mardi des Chercheurs (MdC2018), Valenciennes, France.

Wells, M., Lenaerts, C., & Blankert, B. (2017). Amélioration des techniques d'extraction de la marinobufagénine de matrices complexes. Unpublished master thesis, Université de Mons.
Jury: .

Wells, M., Lenaerts, C., Hambye, S., & Blankert, B. (28 March 2017). Stratégies d'extraction et de purification de la Marinobufagénine à partir du venin du crapaud Bufo marinus. Poster session presented at 12ème Congrès de l'Association Francophone des Sciences Séparatives, Paris, France.

Wells, M., Lenaerts, C., & Blankert, B. (2016). Exploration et perfectionnement des techniques de purification de la Marinobufagénine à partir du venin de Bufo Marinus.

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