Polyelectrolyte complexes based on (quaternized) poly[2-dimethylamino)ethyl methacrylate] : behaviour in contact with blood

Yancheva, Elena; Paneva, Dilyana; Danchev, Dobri; Mespouille, Laetitia; Dubois, Philippe; Manolova, Nevena; Rashkov, Iliya

doi:10.1002/mabi.200700056

Article (Scientific journals)

Polyelectrolyte complexes based on (quaternized) poly[2-dimethylamino)ethyl methacrylate] : behaviour in contact with blood

Yancheva, Elena; Paneva, Dilyana; Danchev, Dobri et al.

2007 • In Macromolecular Bioscience, 7 (7-8), p. 940-954

Peer Reviewed verified by ORBi

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https://hdl.handle.net/20.500.12907/10105

DOI
10.1002/mabi.200700056

PubMed
17578836

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Abstract :

[en] Polyelectrolyte complexes (PECs) between (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N-carboxyethylchitosan (CECh) or poly(2-acrylamido-2-methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility.

Disciplines :

Chemistry

Author, co-author :

Yancheva, Elena

Paneva, Dilyana

Danchev, Dobri

Mespouille, Laetitia

Dubois, Philippe ; Université de Mons > Faculté des Sciences > Matériaux Polymères et Composites

Manolova, Nevena

Rashkov, Iliya

Language :

English

Title :

Polyelectrolyte complexes based on (quaternized) poly[2-dimethylamino)ethyl methacrylate] : behaviour in contact with blood

Publication date :

09 July 2007

Journal title :

Macromolecular Bioscience

ISSN :

1616-5187

eISSN :

1616-5195

Publisher :

John Wiley & Sons, United Kingdom

Volume :

Issue :

7-8

Pages :

940-954

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S816 - Matériaux Polymères et Composites

Research institute :

R400 - Institut de Recherche en Science et Ingénierie des Matériaux

Commentary :

Publié en ligne le 19 juin 2007 Lecture en ligne: http://onlinelibrary.wiley.com/doi/10.1002/mabi.200700056/pdf

Available on ORBi UMONS :

since 10 July 2010

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