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A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?

Yu, G.; Yamashita, M.; Aoshima, Kengo et al.

2007 • In Bioorganic and Medicinal Chemistry Letters, 17 (8), p. 2246-2249

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https://hdl.handle.net/20.500.12907/12833

DOI
10.1016/j.bmcl.2007.01.067

PubMed
17303417

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Keywords :

magnetic resonance imaging; pharmacokinetics; MRI contrast agents

Abstract :

A new low-molecular weight dendrimer-like M RI contrast agent (Gd-D1) has been synthesized and characterized in vitro by proton and oxygen-17 relaxometry. Its pharmacokinetic parameters and biodistribution patterns were evaluated on rats. Its in vitro and in vivo properties, that is, the longitudinal relaxivity (defined as the increase of the water proton longitudinal relaxation rate induced by one millimole per liter of Gd-D1) equal to 5.6 s(-1) mM(-1) at 20 MHz and 310 K, the elimination half-time equal to 85 min, and its low accumulation in liver and spleen, underline its potential as a blood-pool MRI contrast agent.

Research center :

CMMI - Centre de Recherche en Microscopie et Imagerie Médicale

Disciplines :

Pharmacy, pharmacology & toxicology
Radiology, nuclear medicine & imaging
Chemistry

Author, co-author :

Yu, G.

Yamashita, M.

Aoshima, Kengo

Takahashi, M.

Oshikawa, T.

Takayanagi, H.

Laurent, Sophie ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Burtea, Carmen ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Vander Elst, Luce ; Université de Mons > Faculté de Médecine et de Pharmacie > Biochimie métabolique et moléculaire

Muller, Robert ; Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale

Language :

English

Title :

A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?

Publication date :

01 January 2007

Journal title :

Bioorganic and Medicinal Chemistry Letters

ISSN :

0960-894X

eISSN :

1464-3405

Publisher :

Elsevier, United Kingdom

Volume :

17

Issue :

8

Pages :

2246-2249

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

M108 - Chimie générale, organique et biomédicale

Research institute :

R550 - Institut des Sciences et Technologies de la Santé
R100 - Institut des Biosciences

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since 10 June 2010

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Bibliography

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The evaluation of the long time index5 is equal to 0.88 as compared to 0.49 and 0.10 for Gd-DTPA and Gd-DTPA-BMA, respectively.
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