Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.

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Abstract :

[en] Following the identification of a M. tuberculosis phosphate transporter belonging to the superfamily of ABC transporters, we report on the cloning and sequencing of two additional genes, called pstS-3 and pstC-2, encoding proteins homologous to PstS and PstC of Escherichia coli, respectively. Together with the previously isolated M. tuberculosis gene similar to the E. coli pstA, these are included in a cluster encoding a second putative phosphate transport system. We demonstrate that pstS-3 encodes the previously described Ag 88, a 40 kDa M. bovis BCG culture filtrate antigen (immunodominant in H-2b haplotype type mice). Finally, a signature motif identifying integral transmembrane proteins of prokaryotic phosphate binding-dependent permeases is proposed.

Disciplines :

Biochemistry, biophysics & molecular biology
Biotechnology
Zoology

Author, co-author :

Braibant, Martine

Lefèvre, Philippe

de Wit, Lucas

Ooms, Josette

Priska, Peirs

Huygen, Kris

Wattiez, Ruddy ; Université de Mons - UMONS > Faculté des Sciences > Service de Protéomie et Microbiologie

Content, Jean

Language :

English

Title :

Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.

Publication date :

30 September 1996

Journal title :

FEBS Letters

ISSN :

0014-5793

eISSN :

1873-3468

Publisher :

Wiley-Blackwell, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S828 - Protéomie et Microbiologie

Available on ORBi UMONS :

since 24 January 2013

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