Polyelectrolyte complexes between (crosslinked) N-carboxyethylchitosan and (quaternized) poly[2-dimethylamino)ethyl methacrylate: preparation, characterization and antibacterial properties

Yancheva, Elena; Paneva, Dilyana; Maximova, V.; Mespouille, Laetitia; Dubois, Philippe; Manolova, Nevena; Rashkov, Iliya

doi:10.1021/bm061029j

Article (Scientific journals)

Polyelectrolyte complexes between (crosslinked) N-carboxyethylchitosan and (quaternized) poly[2-dimethylamino)ethyl methacrylate: preparation, characterization and antibacterial properties

Yancheva, Elena; Paneva, Dilyana; Maximova, V. et al.

2007 • In Biomacromolecules, 8 (3), p. 976-984

Peer Reviewed verified by ORBi

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https://hdl.handle.net/20.500.12907/15279

DOI
10.1021/bm061029j

PubMed
17315947

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Abstract :

[en] Novel polyelectrolyte complexes (PECs) between N-carboxyethylchitosan (CECh) and well-defined (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) have been obtained. The modification of chitosan into CECh allows the preparation of PECs in a pH range in which chitosan cannot form complexes. The CECh/PDMAEMA complex is formed in a narrow pH range around 7. The quaternization of the tertiary amino groups of PDMAEMA enables complex formation with CECh both in neutral and in alkaline medium. Cross-linked CECh is also capable of forming complexes with (quaternized) PDMAEMA. The antibacterial activity of (cross-linked) CECh, (quaternized) PDMAEMA, and their complexes against Escherichia coli has been evaluated. In contrast to (quaternized) PDMAEMA, (cross-linked) CECh exhibits no antibacterial activity. The complex formation between cross-linked CECh and (quaternized) PDMAEMA results in a loss of the inherent antibacterial activity of the latter in neutral medium. In acidic medium, the complexes exhibit strong antibacterial activity due to complex disintegration and release of (quaternized) PDMAEMA.

Disciplines :

Chemistry

Author, co-author :

Yancheva, Elena

Paneva, Dilyana

Maximova, V.

Mespouille, Laetitia

Dubois, Philippe ; Université de Mons > Faculté des Sciences > Matériaux Polymères et Composites

Manolova, Nevena

Rashkov, Iliya

Language :

English

Title :

Polyelectrolyte complexes between (crosslinked) N-carboxyethylchitosan and (quaternized) poly[2-dimethylamino)ethyl methacrylate: preparation, characterization and antibacterial properties

Publication date :

12 March 2007

Journal title :

Biomacromolecules

ISSN :

1525-7797

eISSN :

1526-4602

Publisher :

American Chemical Society, United States - District of Columbia

Volume :

Issue :

Pages :

976-984

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S816 - Matériaux Polymères et Composites

Research institute :

R400 - Institut de Recherche en Science et Ingénierie des Matériaux

Commentary :

Publié en ligne le 22 février 2007

Available on ORBi UMONS :

since 10 July 2010

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