Metaplastic effect of apamin on LTP and paired-pulse facilitation

[en] In area CA1 of hippocampal slices, a single 1-sec train of 100-Hz stimulation generally triggers a short-lasting long-term potentiation (S-LTP) of 1-2 h. Here, we found that when such a train was applied 45 min after application of the small conductance Ca2+-activated K+ (SK) channel blocker apamin, it induced a long-lasting LTP (L-LTP) of several hours, instead of an S-LTP. Apamin-induced SK channel blockage is known to resist washing. Nevertheless, the aforementioned effect is not a mere delayed effect; it is metaplastic. Indeed, when a single train was delivered to the Schaffer's collaterals during apamin application, it induced an S-LTP, like in the control situation. At the moment of this LTP induction (15th min of apamin application), the SK channel blockage was nevertheless complete. Indeed, at that time, under the influence of apamin, the amplitude of the series of field excitatory postsynaptic potentials (fEPSPs) triggered by a stimulation train was increased. We found that the metaplastic effect of apamin on LTP was crucially dependent on the NO-synthase pathway, whereas the efficacy of the NMDA receptors was not modified at the time of its occurrence. We also found that apamin produced an increase in paired-pulse facilitation not during, but after, the application of the drug. Finally, we found that the induction of each of these two metaplastic phenomena was mediated by NMDA receptors. A speculative unitary hypothesis to explain these phenomena is proposed.

Disciplines :

Neurology

Author, co-author :

Ris, Laurence

Capron, Brigitte

Sclavons, Coralie

Liegeois, Jean-François

Seutin, Vincent

Godaux, Emile ; Université de Mons > Faculté de Médecine et de Pharmacie > Neurosciences

Language :

English

Title :

Metaplastic effect of apamin on LTP and paired-pulse facilitation

Publication date :

01 August 2007

Journal title :

Learning and Memory

ISSN :

1072-0502

Publisher :

Cold Spring Harbor Laboratory Press, United States - New York

Volume :

Issue :

Pages :

390-399

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

M108 - Chimie générale, organique et biomédicale
M119 - Neurosciences
M125 - Biologie humaine et Toxicologie

Available on ORBi UMONS :

since 10 June 2010

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