Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Tinoco, Ana B; Barreiro-Iglesias, Antón; Alfonso Yanez Guerra, Luis; Delroisse, Jérôme; Zhang, Ya; Gunner, Elizabeth F; Zampronio, Cleidiane G; Jones, Alexandra M; Egertova, Michaela; Elphick, Maurice R.

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Tinoco, Ana B; Barreiro-Iglesias, Antón; Alfonso Yanez Guerra, Luis et al.

2021 • In eLife

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https://hdl.handle.net/20.500.12907/25790

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Abstract :

[en] Sulfakinin (SK)/cholecystokinin (CCK)-type neuropeptides regulate feeding and digestion in protostomes (e.g. insects) and chordates. Here, we characterised SK/CCK-type signalling for the first time in a non-chordate deuterostome - the starfish Asterias rubens (phylum Echinodermata). In this species, two neuropeptides (ArSK/CCK1, ArSK/CCK2) derived from the precursor protein ArSK/CCKP act as ligands for an SK/CCK-type receptor (ArSK/CCKR) and these peptides/proteins are expressed in the nervous system, digestive system, tube feet, and body wall. Furthermore, ArSK/CCK1 and ArSK/CCK2 cause dose-dependent contraction of cardiac stomach, tube foot, and apical muscle preparations in vitro, and injection of these neuropeptides in vivo triggers cardiac stomach retraction and inhibition of the onset of feeding in A. rubens. Thus, an evolutionarily ancient role of SK/CCK-type neuropeptides as inhibitory regulators of feeding-related processes in the Bilateria has been conserved in the unusual and unique context of the extra-oral feeding behaviour and pentaradial body plan of an echinoderm.

Research center :

BIOSYS - Biosys

Disciplines :

Architecture
Biotechnology
Phytobiology (plant sciences, forestry, mycology...)
Zoology

Author, co-author :

Tinoco, Ana B

Barreiro-Iglesias, Antón

Alfonso Yanez Guerra, Luis

Delroisse, Jérôme ; Université de Mons > Faculté des Sciences > Service de Biologie des Organismes Marins et Biomimétisme

Zhang, Ya

Gunner, Elizabeth F

Zampronio, Cleidiane G

Jones, Alexandra M

Egertova, Michaela

Elphick, Maurice R.

Language :

English

Title :

Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

Publication date :

07 September 2021

Journal title :

eLife

eISSN :

2050-084X

Publisher :

eLife Sciences Publications, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S864 - Biologie des Organismes Marins et Biomimétisme

Research institute :

R100 - Institut des Biosciences

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