Control of incomplete separation in simulated moving bed chromatographic processes

[en] Simulated moving bed (SMB) is a continuous chromatographic process used for the separation of fluid mixtures. This paper presents a simple control strategy to handle incomplete separation, which requires tight control to achieve the desired purities. At first, a discrete-time nonlinear model is derived from wave theory, which will be the basis to estimate the position of the adsorption and desorption fronts. Four controllers are designed, two for the position of the concentration waves in zone 1 and 4, and two for the purities at the extract and raffinate outlets. The performance of the control strategy is evaluated with an experimental study of the separation of racemic Bicalutamide enantiomers in a 4 column-SMB.

Research center :

BIOSYS - Biosys

Disciplines :

Chemical engineering
Electrical & electronics engineering

Author, co-author :

Suvarov, Paul ; Université de Mons > Faculté des Sciences > Ecologie numérique

Vande Wouwer, Alain ; Université de Mons > Faculté Polytechnique > Service Systèmes, Estimation, Commande et Optimisation

Lee, Ju Weon

Seidel-Morgenstern, Andreas

KIENLE, Achim

Language :

English

Title :

Control of incomplete separation in simulated moving bed chromatographic processes

Publication date :

06 June 2016

Event name :

11th IFAC Symposium on Dynamics and Control of Process Systems, including Biosystems (DYCOPS-CAB 2016)

Event place :

Trondheim, Norway

Event date :

2016

Research unit :

F107 - Systèmes, Estimation, Commande et Optimisation

Research institute :

R100 - Institut des Biosciences

Available on ORBi UMONS :

since 13 January 2017

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Bibliography

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