Article (Scientific journals)
Synapse specificity of long-term potentiation breaks down with aging
Ris, Laurence; Godaux, Emile
2007In Learning and Memory, 14 (3), p. 185-189
Peer Reviewed verified by ORBi
 

Files


Full Text
GODAUX_2007_3_JOURNAL.pdf
Author postprint (569.2 kB)
Request a copy

All documents in ORBi UMONS are protected by a user license.

Send to



Details



Abstract :
[en] Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent fibers in slices from 12-mo-old mice triggers an LTP not restricted to the activated synapses. This phenomenon, which can be anticipated to hinder memory encoding, is suppressed by blocking either L-type Ca++ channels or Ca++-induced Ca++ release, both well known to become disregulated with aging.
Disciplines :
Neurology
Author, co-author :
Ris, Laurence 
Godaux, Emile ;  Université de Mons > Faculté de Médecine et de Pharmacie > Neurosciences
Language :
English
Title :
Synapse specificity of long-term potentiation breaks down with aging
Publication date :
01 March 2007
Journal title :
Learning and Memory
ISSN :
1072-0502
Publisher :
Cold Spring Harbor Laboratory Press, United States - New York
Volume :
14
Issue :
3
Pages :
185-189
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
M119 - Neurosciences
Available on ORBi UMONS :
since 10 June 2010

Statistics


Number of views
7 (0 by UMONS)
Number of downloads
0 (0 by UMONS)

Scopus citations®
 
23
Scopus citations®
without self-citations
18
OpenCitations
 
15

Bibliography


Similar publications



Contact ORBi UMONS