Adhesion/growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas
[en] Background: Galectin-1 has been found to modulate lymphocyte invasion in inflammation and to be involved in angiogenesis in models, thus prompting examination of its clinical relevance in laryngeal cancer. Patients and Methods: Immunohistochemical processing of tissue sections (n=53) from patients with stage I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was combined with quantitative morphometric analysis. Results: Lectin presence in the tumor and endothelial cells was positively correlated, while a negative relationship to the number of CD45-positive lymphocytes was demonstrated. No association was seen with the extent of neovascularization. The mean optical density (MOD) of lectin-dependent staining in the tumor stroma was significantly increased compared to normal stroma. Conclusion: Galectin-1 was not associated with angiogenesis in the studied cohort while galectin-1 in endothelial cells may negatively influence lymphocyte invasion and the mean optical density for the stromal galectin-1 signal is up-regulated in tumors.
Disciplines :
Immunologie & maladie infectieuse Oncologie
Auteur, co-auteur :
Saussez, Sven ; Université de Mons > Faculté de Médecine et de Pharmacie > Anatomie humaine et Oncologie expérimentale
Decaestecker, Christine
Cludts, Stéphanie
Ernoux, Perle
Chevalier, Dominique
Smetana, Karel
André, Sabine
Leroy, Xavier
Gabius, Hans-Joachim
Langue du document :
Anglais
Titre :
Adhesion/growth-regulatory Tissue Lectin Galectin-1 in Relation to Angiogenesis/lymphocyte Infiltration and Prognostic Relevance of Stromal Up-regulation in Laryngeal Carcinomas
Date de publication/diffusion :
01 janvier 2009
Titre du périodique :
Anticancer Research
ISSN :
0250-7005
eISSN :
1791-7530
Maison d'édition :
International Institute of Anticancer Research, Grèce
Volume/Tome :
29
Fascicule/Saison :
1
Pagination :
59-65
Peer reviewed :
Peer reviewed vérifié par ORBi
Unité de recherche :
M112 - Anatomie humaine et Oncologie expérimentale
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