Patent (Patents)
Peptides binding to LDL receptor as carriers for crossing the blood-brain barrier
Burtea, Carmen; Andre, Séverine; Laurent, Sophie
2019
 

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Keywords :
[en] LDL receptor; [en] peptides; [en] phage display; [en] blood-brain barrier; [en] receptor-mediated transcytosis
Abstract :
[en] The current invention concerns peptides capable of binding to LDL-receptor, wherein said peptide has at least 90% sequence identity to an amino acid sequence chosen from SEQ ID 1 to 12, and it concerns peptides capable of binding to LDL-receptor, wherein said peptide has an amino acid sequence that differs maximally two amino acids from SEQ ID 1 to 12, as well as conjugate compounds comprising such peptides, as well as the use of such peptides in compositions.
Research center :
CMMI - Centre de Recherche en Microscopie et Imagerie Médicale
Disciplines :
Immunology & infectious disease
Neurology
Pharmacy, pharmacology & toxicology
Radiology, nuclear medicine & imaging
Biotechnology
Zoology
Chemistry
Inventor :
Burtea, Carmen  ;  Université de Mons > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Andre, Séverine ;  Université de Mons > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Laurent, Sophie  ;  Université de Mons > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Language :
English
Title (54) :
Peptides binding to LDL receptor as carriers for crossing the blood-brain barrier
Publication date (43-45) :
10 December 2019
Filing date (22) :
08 December 2020
Priority number (30) :
19214905.2 EP 10.12.2019
Applicant (71) :
Université de Mons
Research unit :
M108 - Chimie générale, organique et biomédicale
Research institute :
R550 - Institut des Sciences et Technologies de la Santé
R100 - Institut des Biosciences
Name of the research project :
Development of a molecular strategy for Alzheimer's disease therapy by modulation of a phospholipase A2 isoform - Sources privées
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since 02 January 2020

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