[en] Novel fibrous materials of stereocomplex between high-molecular-weight poly(d- or l-)lactide (HMPDLA or HMPLLA) and diblock copolymers consisting of poly(l- or d-)lactide and poly(N,N-dimethylamino-2-ethyl methacrylate) blocks, respectively (PLLA-block-PDMAEMA or PDLA-block-PDMAEMA), were prepared by solution electrospinning. Fibers with mean diameters ranging from 1400 to 1700 nm were obtained. The stereocomplex formation was evidenced by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses. Annealing at 100 °C for 8 h resulted in the appearance of crystalline peaks at 2? values of 12, 21, and 24° for PLA stereocomplex. X-ray photoelectron spectroscopy (XPS) analyses revealed the gradient composition of the fibers with a surface enriched in tertiary amino groups from PDMAEMA blocks. The availability of tertiary amino groups imparts hemostatic and antibacterial properties to the stereocomplex fibrous materials, as indicated by the performed tests on blood cells and on pathogenic microorganisms.
Disciplines :
Chemistry
Author, co-author :
Spasova, M.
Manolova, Nevena
Paneva, Dilyana
Mincheva, Rosica ; Université de Mons > Faculté des Sciences > Matériaux Polymères et Composites
Dubois, Philippe ; Université de Mons > Faculté des Sciences > Matériaux Polymères et Composites
Rashkov, Iliya
Maximova, V.
Danchev, Dobri
Language :
English
Title :
Novel polylactide stereocomplex-based electrospun materials possessing surface with antibacterial and haemostatic properties
Publication date :
11 January 2010
Journal title :
Biomacromolecules
ISSN :
1525-7797
Publisher :
American Chemical Society, United States - District of Columbia
Volume :
11
Issue :
1
Pages :
151-159
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
S816 - Matériaux Polymères et Composites
Research institute :
R400 - Institut de Recherche en Science et Ingénierie des Matériaux