Cytokine Landscape in Central Nervous System Metastases.

{"lastName":"Marin", "firstNames":"Julie","affiliations":["Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium"],"ids":["SC:57783306000""OR:0000-0003-1167-9613"]}; Journe, Fabrice; Ghanem, Ghanem E; {"lastName":"Awada", "firstNames":"Ahmad","affiliations":["Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium","Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium"],"ids":["SC:26643168900""OR:0000-0001-7412-9163"]}; Kindt, Nadège

doi:10.3390/biomedicines10071537

Article (Scientific journals)

Cytokine Landscape in Central Nervous System Metastases.

{"lastName":"Marin", "firstNames":"Julie","affiliations":["Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium"],"ids":["SC:57783306000""OR:0000-0003-1167-9613"]}; Journe, Fabrice; Ghanem, Ghanem E et al.

2022 • In Biomedicines, 10 (7), p. 1537

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https://hdl.handle.net/20.500.12907/44729

DOI
10.3390/biomedicines10071537

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35884845

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Keywords :

brain metastases; leptomeningeal metastases; microenvironment; microglia and cytokines; reactive astrocytes; Medicine (miscellaneous); Biochemistry, Genetics and Molecular Biology (all); General Biochemistry, Genetics and Molecular Biology

Abstract :

[en] The central nervous system is the location of metastases in more than 40% of patients with lung cancer, breast cancer and melanoma. These metastases are associated with one of the poorest prognoses in advanced cancer patients, mainly due to the lack of effective treatments. In this review, we explore the involvement of cytokines, including interleukins and chemokines, during the development of brain and leptomeningeal metastases from the epithelial-to-mesenchymal cell transition and blood-brain barrier extravasation to the interaction between cancer cells and cells from the brain microenvironment, including astrocytes and microglia. Furthermore, the role of the gut-brain axis on cytokine release during this process will also be addressed.

Disciplines :

Oncology

Author, co-author :

Journe, Fabrice ; Université de Mons - UMONS ; Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium

Ghanem, Ghanem E; Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium

{"lastName":"Awada", "firstNames":"Ahmad","affiliations":["Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium","Department of Medical Oncology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium"],"ids":["SC:26643168900""OR:0000-0001-7412-9163"]}

Kindt, Nadège; Laboratory of Clinical and Experimental Oncology (LOCE), Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium

Language :

English

Title :

Cytokine Landscape in Central Nervous System Metastases.

Publication date :

28 June 2022

Journal title :

Biomedicines

eISSN :

2227-9059

Publisher :

MDPI, Switzerland

Volume :

Issue :

Pages :

1537

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.mdpi.com/2227-9059/10/7/1537/pdf

Research institute :

R550 - Institut des Sciences et Technologies de la Santé

Funders :

Fund for Scientific Research

Funding text :

Acknowledgments: This work was supported by ‘Amis de l’Institut Bordet’.J.M. is supported by a research grant from Fonds De La Recherche Scientifique‐FNRS (Télévie), number 7.4505.21.

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