Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer’s Disease
[en] The logopenic variant of primary progressive aphasia (lvPPA) shows different features
from the non-fluent (nfvPPA) and semantic (svPPA) variants of PPA. Although language impairments remain the core symptoms, studies have highlighted the presence of executive disorders at the onset of the disease. Nevertheless, the results are contradictory, particularly in lvPPA. The aim of this study was to explore the executive profile of lvPPA. We compared executive functioning in lvPPA with the other two variants of PPA, Alzheimer’s disease (AD) and a cognitively healthy group. In total, 70 patients with PPA, 32 patients with AD, and 41 healthy controls were included. They underwent a comprehensive executive battery assessing short-term and working memory, inhibition, flexibility, planning, and initiation. The analyses showed significant differences between the lvPPA group and the control group, except on visuospatial spans and the Stroop test, and between the lvPPA group and the other PPA groups and the AD group for several tasks. Thus, this research highlighted the existence of an executive dysfunction from the onset of the disease in lvPPA but also in the other two variants of PPA.
Research center :
CIPSE - Centre de recherche interdisciplinaire en Psychophysiologie et Electrophysiologie de la cognition
Disciplines :
Neurosciences & behavior
Author, co-author :
Basaglia-Pappas, Sandrine
Bernard, Laurent; North Hospital, University Hospital Center, CEDEX 2, 42055 Saint-Etienne, France > Department of Neurology and Neuropsychology > Memory Center
Getenet, Jean-Claude; North Hospital, University Hospital Center, CEDEX 2, 42055 Saint-Etienne, France > Department of Neurology and Neuropsychology > Memory Center
Boulangé, Anne; North Hospital, University Hospital Center, CEDEX 2, 42055 Saint-Etienne, France > Department of Neurology and Neuropsychology > Memory Center
Simoes loureiro, Isabelle ; Université de Mons - UMONS > Faculté de Psychologie et des Sciences de l'Education > Service de Psychologie cognitive et Neuropsychologie
Rendon de la cruz, Aurélia ; Université de Mons - UMONS > Faculté de Psychologie et des Sciences de l'Education > Service de Psychologie cognitive et Neuropsychologie
Lefebvre, Laurent ; Université de Mons - UMONS > Faculté de Psychologie et des Sciences de l'Education > Service de Psychologie cognitive et Neuropsychologie
Language :
English
Title :
Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer’s Disease
Publication date :
22 February 2023
Journal title :
Brain Sciences
eISSN :
2076-3425
Publisher :
MDPI AG, Basel, Switzerland
Volume :
13
Issue :
3
Pages :
1-14
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
P325 - Psychologie cognitive et Neuropsychologie
Research institute :
R550 - Institut des Sciences et Technologies de la Santé
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