[en] Optical biosensors are frontrunners for the rapid and real-time detection of analytes, particularly for low concentrations. Among them, whispering gallery mode (WGM) resonators have recently attracted a growing focus due to their robust optomechanical features and high sensitivity, measuring down to single binding events in small volumes. In this review, we provide a broad overview of WGM sensors along with critical advice and additional "tips and tricks" to make them more accessible to both biochemical and optical communities. Their structures, fabrication methods, materials, and surface functionalization chemistries are discussed. We propose this reflection under a pedagogical approach to describe and explain these biochemical sensors with a particular focus on the most recent achievements in the field. In addition to highlighting the advantages of WGM sensors, we also discuss and suggest strategies to overcome their current limitations, leaving room for further development as practical tools in various applications. We aim to provide new insights and combine different knowledge and perspectives to advance the development of the next generation of WGM biosensors. With their unique advantages and compatibility with different sensing modalities, these biosensors have the potential to become major game changers for biomedical and environmental monitoring, among many other relevant target applications.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Loyez, Médéric ; Université de Mons - UMONS > Facult?des Sciences > Service de Prot?mie et Microbiologie ; Department of Electrical & Systems Engineering, Washington University, One Brookings Drive Green Hall 2120F, St. Louis, Missouri 63130, United States
Adolphson, Maxwell; Department of Electrical & Systems Engineering, Washington University, One Brookings Drive Green Hall 2120F, St. Louis, Missouri 63130, United States
Liao, Jie ; Department of Electrical & Systems Engineering, Washington University, One Brookings Drive Green Hall 2120F, St. Louis, Missouri 63130, United States
Yang, Lan; Department of Electrical & Systems Engineering, Washington University, One Brookings Drive Green Hall 2120F, St. Louis, Missouri 63130, United States
Language :
English
Title :
From Whispering Gallery Mode Resonators to Biochemical Sensors.
Belgian American Educational Foundation National Institutes of Health
Funding text :
We thank the support from the Belgian American Educational Foundation (B.A.E.F.) https://baef.be providing the postdoctoral fellowship for Médéric Loyez. We acknowledge the support from the National Institutes of Health under the award number R21EB030845. The authors acknowledge the help of Wenbo Mao, Di Jia, and Zhoutian Fu for their advice during the writing process.
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