Active targeting, head cancer; Bioconjugation; Coupling; Iron oxide; Magnetic Nanoparticles; Neck cancer; Peptide 22; Ligands; Epidermal Growth Factor; ErbB Receptors; Magnetite Nanoparticles; Humans; ErbB Receptors/metabolism; Magnetic Iron Oxide Nanoparticles; Magnetic Resonance Imaging/methods; Hyperthermia, Induced; Nanoparticles/chemistry; Head and Neck Neoplasms/drug therapy; Magnetite Nanoparticles/chemistry; Head and Neck Neoplasms; Magnetic Resonance Imaging; Nanoparticles; Pharmaceutical Science
Abstract :
[en] A major challenge in nanomedicine is designing nanoplatforms (NPFs) to selectively target abnormal cells to ensure early diagnosis and targeted therapy. Among developed NPFs, iron oxide nanoparticles (IONPs) are good MRI contrast agents and can be used for therapy by hyperthermia and as radio-sensitizing agents. Active targeting is a promising method for selective IONPs accumulation in cancer tissues and is generally performed by using targeting ligands (TL). Here, a TL specific for the epidermal growth factor receptor (EGFR) is bound to the surface of dendronized IONPs to produce nanostructures able to specifically recognize EGFR-positive FaDu and 93-Vu head and neck cancer cell lines. Several parameters were optimized to ensure a high coupling yield and to adequately quantify the amount of TL per nanoparticle. Nanostructures with variable amounts of TL on the surface were produced and evaluated for their potential to specifically target and be thereafter internalized by cells. Compared to the bare NPs, the presence of the TL at the surface was shown to be effective to enhance their internalization and to play a role in the total amount of iron present per cell.
Research center :
CMMI - Centre de Recherche en Microscopie et Imagerie Médicale CISMA - Centre Interdisciplinaire de Spectrométrie de Masse
Disciplines :
Chemistry
Author, co-author :
Freis, Barbara ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale
Ramírez, María De Los Ángeles; Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux, UMR CNRS-UdS 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg, France
Furgiuele, Sonia ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service d'Anatomie humaine et Oncologie expérimentale
Journe, Fabrice ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service d'Anatomie humaine et Oncologie expérimentale
Cheignon, Clémence; Université de Strasbourg, CNRS, Institut Pluridisciplinaire Hubert Curien, UMR 7178, 25, rue Becquerel, 67087 Strasbourg, France
Charbonnière, Loïc J; Université de Strasbourg, CNRS, Institut Pluridisciplinaire Hubert Curien, UMR 7178, 25, rue Becquerel, 67087 Strasbourg, France
Henoumont, Céline ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service de Chimie générale, organique et biomédicale
Kiefer, Celine; Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux, UMR CNRS-UdS 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg, France
Mertz, Damien; Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux, UMR CNRS-UdS 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg, France
Affolter-Zbaraszczuk, Christine; Inserm U1121, Centre de recherche en biomédecine de Strasbourg, 1 rue Eugène Boeckel, CS 60026, 67084 Strasbourg Cedex, France
Meyer, Florent; Inserm U1121, Centre de recherche en biomédecine de Strasbourg, 1 rue Eugène Boeckel, CS 60026, 67084 Strasbourg Cedex, France
Saussez, Sven ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service d'Anatomie humaine et Oncologie expérimentale
Laurent, Sophie ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service de Chimie générale, organique et biomédicale
Tasso, Mariana; Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux, UMR CNRS-UdS 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg, France, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata - CONICET, Diagonal 113 y 64, 1900 La Plata, Argentina
Bégin-Colin, Sylvie; Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux, UMR CNRS-UdS 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg, France. Electronic address: sylvie.begin@unistra.fr
M108 - Chimie générale, organique et biomédicale M112 - Anatomie humaine et Oncologie expérimentale
Research institute :
R550 - Institut des Sciences et Technologies de la Santé R100 - Institut des Biosciences
Funders :
Region wallonne EuroNanoMed III
Funding text :
The Region Alsace, France, and the University of Mons are gratefully acknowledged for the doctoral fellowship to Barbara Freis. This project received funding from ANR (EURONANOMED2020-121 - THERAGET) under the umbrella of the ERA-NET EuroNanoMed (GA N°723770) of the EU Horizon 2020 Research and Innovation and ProtherWal “Walloon Region via the ProtherWal Society (Agreement 7289). SuperBranche is thanked for providing dendron molecules. M.T. acknowledges support from CONICET (Argentina) and from the Ministry of Science, Technology and Innovation. UMONS acknowledges the financial support of the Fond National de la Recherche Scientifique (FNRS), the ARC Programs of the French Community of Belgium, COST actions and the Walloon region (ProtherWal and Interreg projects). S.F. acknowledges UMONS, EpiCURA Hospital, ProtherWal and the Fund for Medical Research in Hainaut (FRMH). The authors thank the XRD platform of the IPCMS.
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