[en] We proposed a hydrogel grating sensor functionalized with phenylboronic acid (PBA) group for glucose concentration detection. A PBA functionalized polyacrylamide hydrogel film was first prepared via ultraviolet polymerization. Then, the diffraction grating was written on the hydrogel film via the femto-second (fs) laser point-by-point direct inscription. Binding between the PBA groups in the hydrogel and glucose molecules would lead to the swelling of hydrogel and the thus grating structure, thus modifying the diffraction properties of the grating. We experimentally characterized the swelling and transmission of the grating with different glucose concentrations. Sensitivity of the sensor was defined as variations in relative diffraction efficiency in response to glucose concentration changes, and was experimentally found to 0.61%/mM. The proposed sensor showed fast response towards the presence of glucose, and its reusability and biocompatibility were also confirmed. The use of fs-laser inscription technique does not require a pre-fabricated template, and would allow to directly modify the fabrication parameters such as scanning speed, pulse energy and frequency. Therefore, one is able to conveniently optimize the grating structure and improve the inscription efficiency. The proposed hydrogel grating could be potentially fabricated into wearable sensors, namely, contact lenses, for continuous monitoring of tear glucose level with rapid response.
Disciplines :
Electrical & electronics engineering
Author, co-author :
Wen, Xin; Joint Shantou International Eye Center of Shantou University, The Chinese University of HongKong, Shantou, China ; Shantou University Medical College, Shantou, China
Liu, Yang; Research Center for Advanced Optics and Photoelectronics, Department of Physics, College of Science, Shantou University, Shantou, China
Liu, Qingping; Joint Shantou International Eye Center of Shantou University, The Chinese University of HongKong, Shantou, China
Chen, Zhen; Research Center for Advanced Optics and Photoelectronics, Department of Physics, College of Science, Shantou University, Shantou, China
Hu, Xuehao ; Université de Mons - UMONS > Recherche > Service ERC Unit - Advanced Photonic ; Research Center for Advanced Optics and Photoelectronics, Department of Physics, College of Science, Shantou University, Shantou, China
Xu, Ciyan; Joint Shantou International Eye Center of Shantou University, The Chinese University of HongKong, Shantou, China
Chen, Haoyu; Joint Shantou International Eye Center of Shantou University, The Chinese University of HongKong, Shantou, China
Xing, Malcolm; Department of Mechanical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, Canada
Qu, Hang; Research Center for Advanced Optics and Photoelectronics, Department of Physics, College of Science, Shantou University, Shantou, China
Zhang, Mingzhi; Joint Shantou International Eye Center of Shantou University, The Chinese University of HongKong, Shantou, China
Language :
English
Title :
Glucose sensing based on hydrogel grating incorporating phenylboronic acid groups.
Publication date :
19 December 2022
Journal title :
Optics Express
eISSN :
1094-4087
Publisher :
Optica Publishing Group (formerly OSA), United States
Research Institute for Materials Science and Engineering
Funders :
Recherche Scientifique (FNRS, Belgium) under the Postdoctoral Researcher grant (C.R.) of Xuehao Hu Science and Technology Department of Guangdong Province 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant
Funding text :
Funding. Recherche Scientifique (FNRS, Belgium) under the Postdoctoral Researcher grant (C.R.) of Xuehao Hu (FRS-FNRS); Science and Technology Department of Guangdong Province (No. 2022A1515012571); 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant (No. 2020LKSFG14B).
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