Insulin biotrapping using plasmofluidic optical fiber chips: A benchmark.

Biacore; Biosensor; Insulin detection; Optical fiber; Plasmonics; Tilted fiber bragg grating (TFBG); Insulin; Benchmarking; Reproducibility of Results; Optical Fibers; Biosensing Techniques/methods; Integrated device; Multimode optical fibers; Optical fiber-based biosensors; Plasmofluidics; Tilted fiber bragg grating; White light; Biosensing Techniques; Biotechnology; Biophysics; Biomedical Engineering; Electrochemistry

Abstract :

[en] Plasmonic optical fiber-based biosensors are currently in their early stages of development as practical and integrated devices, gradually making their way towards the market. While the majority of these biosensors operate using white light and multimode optical fibers (OFs), our approach centers on single-mode OFs coupled with tilted fiber Bragg gratings (TFBGs) in the near-infrared wavelength range. Our objective is to enhance surface sensitivity and broaden sensing capabilities of OF-based sensors to develop in situ sensing with remote interrogation. In this study, we comprehensively assess their performance in comparison to the gold-standard plasmonic reference, a commercial device based on the Kretschmann-Raether prism configuration. We present their refractive index sensitivity and their capability for insulin sensing using a dedicated microfluidics approach. By optimizing a consistent surface biotrapping methodology, we elucidate the dynamic facets of both technologies and highlight their remarkable sensitivity to variations in bulk and surface properties. The one-to-one comparison between both technologies demonstrates the reliability of optical fiber-based measurements, showcasing similar experimental trends obtained with both the prismatic configuration and gold-coated TFBGs, with an even enhanced limit of detection for the latter. This study lays the foundation for the detection of punctual molecular interactions and opens the way towards the detection of spatially and temporally localized events on the surface of optical probes.

Disciplines :

Chemical engineering

Author, co-author :

Loyez, Médéric ; Proteomics and Microbiology Department, University of Mons (UMONS), 7000, Belgium, Electromagnetism and Telecom. Department, University of Mons (UMONS), 7000, Belgium. Electronic address: mederic.loyez@umons.ac.be

Fasseaux, Hadrien ; Université de Mons - UMONS > Recherche > Service ERC Unit - Advanced Photonic

Lobry, Maxime ; Université de Mons - UMONS > Faculté Polytechnique > Service d'Electromagnétisme et Télécommunications

Wattiez, Ruddy ; Université de Mons - UMONS > Faculté des Sciences > Service de Protéomie et Microbiologie

Caucheteur, Christophe ; Université de Mons - UMONS > Faculté Polytechnique > Service d'Electromagnétisme et Télécommunications

Language :

English

Title :

Insulin biotrapping using plasmofluidic optical fiber chips: A benchmark.

Publication date :

15 June 2024

Journal title :

Biosensors and Bioelectronics

ISSN :

0956-5663

eISSN :

1873-4235

Publisher :

Elsevier Ltd, England

Volume :

254

Pages :

116189

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0956566324001945?httpAccept=text/xml

Research unit :

Proteomics and Microbiology

Research institute :

Biosciences

Funders :

FRS-FNRS

Funding text :

The authors thank the “Fonds National de la Recherche Scientifique” (F.R.S./FNRS, Belgium) for supporting the research project. The authors thank the help of Dr. Vanya Uzunova and the team of Cytiva for their help with data analysis and use of equipment.

Available on ORBi UMONS :

since 26 June 2024

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