Mn-Based MRI Contrast Agents: An Overview

[en] MRI contrast agents are required in the clinic to detect some pathologies, such as cancers. Nevertheless, at the moment, only small extracellular and non-specific gadolinium complexes are available for clinicians. Moreover, safety issues have recently emerged concerning the use of gadolin iumcomplexes; hence, alternatives are urgently needed. Manganese-based MRI contrast agents could be one of these alternatives and increasing numbers of studies are available in the literature. This review aims at synthesizing all the research, from small Mn complexes to nanoparticular agents, including theranostic agents, to highlight all the efforts already made by the scientific community to obtain highly efficient agents but also evidence of the weaknesses of the developed systems.

Research center :

CMMI - Centre de Recherche en Microscopie et Imagerie Médicale

Disciplines :

Chemistry

Author, co-author :

Henoumont, Céline ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale

Devreux, Marie ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale

Laurent, Sophie ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie générale, organique et biomédicale

Language :

English

Title :

Mn-Based MRI Contrast Agents: An Overview

Publication date :

2024

Main work title :

Prime Archives in Molecular Sciences

Author, co-author :

Zarina, Noor

Wahab, Abd

Publisher :

Vide leaf, Hyderabad, India

Edition :

4th Edition

Peer reviewed :

Peer reviewed

Research unit :

M108 - Chimie générale, organique et biomédicale

Research institute :

R550 - Institut des Sciences et Technologies de la Santé
R100 - Institut des Biosciences

Available on ORBi UMONS :

since 05 November 2024

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