Patent (Patents)
Compounds for the diagnosis of diseases associated with VCAM expression
Port, Marc; Rousseaux, Olivier; Muller, Robert et al.
2008
 

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Keywords :
[en] VCAM-1; [en] molecular targeting; [en] molecular imaging; [en] MRI contrast agents; [en] inflammation; [en] peptides; [en] atherosclerosis; [en] functionalized iron oxide nanoparticles
Abstract :
[en] The invention relates to a compound of the following general formula (I): Signal-Link-Peptide in which Signal is a signal entity, Link is present or absent and is a chemical bond, and Peptide is a peptide including a VCAM targeting peptide, the VCAM targeting peptide being selected from peptides of the following formula and the functional equivalents thereof: a) X1-X2-X3-X4-X5-X6-X7-X8-X9 (1) (SEQ ID NoI) where X1 is absent or present and is selected from cysteine, methionine, X2 is selected from aspargine or glutamine, X3 is selected from aspargine or glutamine, X4 is selected from serine, threonine, X5 is selected from lysine, arginine, histidine, ornithine, X6 is selected from serine, threonine, X7 is selected from histidine, arginine, lysine, X8 is selected from threonine, serine, X9 is absent or present and is selected from cysteine, methionine; preferably the peptide peptide NNSKSHT (SEQ ID No3) b) X10-X11-X12-X13-X14-X15-X16-X17-X18 (2) (SEQ ID No4) wherein X10 is selected from cysteine, methionine, X11 is selected from methionine, cysteine, X12 is selected lysine, arginine, alanine, X13 is selected from threonine, serine, X14 is selected from is selected aspartic acid, glutamic acid, X15 is selected from threonine, serine, X16 is selected from arginine, alanine, lysine, X17 is selected from leucine, isoleucine, valine, X18 is selected from cysteine, methionine; preferably the peptide CMKTDTRLC (SEQ ID No5); and the pharmaceutically acceptable salts of the compounds a) or b).
Disciplines :
Cardiovascular & respiratory systems
Radiology, nuclear medicine & imaging
Biotechnology
Chemistry
Inventor :
Port, Marc
Rousseaux, Olivier
Muller, Robert ;  Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale
Burtea, Carmen  ;  Université de Mons > Faculté de Médecine et de Pharmacie > Chimie générale, organique et biomédicale
Language :
French
Title (54) :
Compounds for the diagnosis of diseases associated with VCAM expression
Publication date (43-45) :
23 October 2008
Filing date (22) :
28 March 2008
Patent/publication number (10-11) :
WO2008125464A1
Priority number (30) :
0754087 FR 28.03.2007
International classification (IPC) (51) :
A61K38/08
C07K7/06
G01N33/68
European classification (ECLA) (52) :
A61K49/0008
A61K49/0056
A61K49/14
A61K49/186
A61K49/1866
A61P13/12
A61P9/00
B82Y5/00
C07K7/06
Applicant (71) :
BURTEA Carmen
Guerbet S.A.
MULLER Robert
PORT Marc
ROUSSEAUX Olivier
Publication organism (19) :
WIPO - World Intellectual Property Organization
Research unit :
M108 - Chimie générale, organique et biomédicale
Available on ORBi UMONS :
since 25 December 2010

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