Profil

Dufrasne François

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie thérapeutique et Pharmacognosie

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > FMP - Service du Doyen


Main Referenced Co-authors
Gelbcke, Michel (21)
Nève, Jean (21)
Van Antwerpen, P. (20)
Soubhye, Jalal (15)
Zouaoui Boudjeltia, Karim  (12)
Main Referenced Keywords
[en] Alzheimer's disease (1); [en] LDLR (1); [en] molecular therapy (1); [en] peptides (1); [en] phospholipase A2 (1);
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (46)
Chemistry (6)
Anesthesia & intensive care (1)

Publications (total 50)

The most downloaded
2 downloads
Dufrasne, F. (24 December 2021). Baloxavir Marboxil: An Original New Drug against Influenza. Pharmaceuticals, 15 (1). https://hdl.handle.net/20.500.12907/22568
The most cited
115 citations (Scopus®)
lamoral-thys, D., Pottier, L., Dufrasne, F., Nève, J., Dubois, J., Kiss, R., Kornienko, A., & Ingrassia, L. (10 April 2010). Natural polyphenols that display anticancer properties through inhibition of kinase activity. Frontiers in Neuroscience, 13 (9), 812-825. https://hdl.handle.net/20.500.12907/13788

Marloye, M., Inam, H., Moore, C. J., Mertens, T. R., Ingels, A., Koch, M., Nowicki, M. O., Mathieu, V., Pritchard, J. R., Awuah, S. G., Lawler, S. E., Meyer, F., Dufrasne, F., & Berger, G. (07 June 2022). Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorganic Chemistry Frontiers, 9 (11), 2594 - 2607. doi:10.1039/d2qi00423b
Peer reviewed

Dufrasne, F. (24 December 2021). Baloxavir Marboxil: An Original New Drug against Influenza. Pharmaceuticals, 15 (1).
Peer reviewed

Marloye, M., Inam, H., Moore, C. J., Debaille, V., Pritchard, J. R., Gelbcke, M., Meyer, F., Dufrasne, F., & Berger, G. (26 June 2021). Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes. Journal of Biological Inorganic Chemistry, 26 (5), 535-549.
Peer Reviewed verified by ORBi

Soubhye, J., Furtmuller, P. G., Dufrasne, F., & Obinger, C. (2020). Inhibition of Myeloperoxidase. In Handbook of experimental pharmacology (pp. 261-288). Editions Springer.

Casas, A. I., Nogales, C., Mucke, H. A. M., Petraina, A., Cuadrado, A., Ghezzi, P., Jaquet, V., Augsburger, F., Dufrasne, F., Soubhye, J., Deshwal, S., Di Sante, M., Kaludercic, N., Di Lisa, F., & Schmidt, H. H. H. W. (2020). On the clinical pharmacology of reactive oxygen species. Pharmacological Reviews.
Peer Reviewed verified by ORBi

Soubhye, J., Van Antwerpen, P., & Dufrasne, F. (18 June 2020). A patent review of myeloperoxidase inhibitors for treating chronic inflammatory syndromes (focus on cardiovascular diseases, 2013-2019). Expert Opinion on Therapeutic Patents, 30 (8), 595-608.
Peer Reviewed verified by ORBi

Soubhye, J., Van Antwerpen, P., & Dufrasne, F. (31 December 2018). Targeting Cytosolic Phospholipase A2α for Novel Anti-​Inflammatory Agents. Current Medicinal Chemistry, 25 (21), 2418-2447.

Rens, C., Laval, F., Wattiez, R., Lefèvre, P., Dufrasne, F., Daffé, M., & Fontaine, V. (22 October 2017). I3-Ag85 effect on phthiodiolone dimycocerosate synthesis. Tuberculosis, 108, 93-95.
Peer Reviewed verified by ORBi

Soubhye, J., Chikh Alard, I., Aldib, I., Prévost, M., Gelbcke, M., De Carvalho, A.-L., Furtmuller, P. G., Obinger, C., Flemming, J., Tadrent, S., Meyer, F., Rousseau, A., Nève, J., Mathieu, V., Zouaoui Boudjeltia, K., Dufrasne, F., & Van Antwerpen, P. (03 July 2017). Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors using Virtual Screening Procedure. Journal of Medicinal Chemistry, 60 (15), 6563-6586.
Peer Reviewed verified by ORBi

Soubhye, J., Gelbcke, M., Van Antwerpen, P., Dufrasne, F., Boufadi, Y., Nève, J., Furtmuller, P. G., Obinger, C., Zouaoui Boudjeltia, K., & Meyer, F. (02 December 2016). From dynamic combinatorial chemistry to in vivo evaluation of reversible and irreversible myeloperoxidase inhibitors. ACS Medicinal Chemistry Letters, 8 (2), 206-210.
Peer reviewed

Marloye, M., Berger, G., Gelbcke, M., & Dufrasne, F. (01 December 2016). A survey of the mechanisms of action of anticancer transition metal complexes. Future Medicinal Chemistry, 8 (18), 2263-86.
Peer Reviewed verified by ORBi

Aldib, I., Gelbcke, M., Soubhye, J., Prévost, M., Furtmuller, P. G., Obinger, C., Elfving, B., Chikh Alard, I., Roos, G., Delporte, C., Berger, G., Dufour, D., Zouaoui Boudjeltia, K., Nève, J., Dufrasne, F., & Van Antwerpen, P. (10 November 2016). Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study. European Journal of Medicinal Chemistry, 123, 746-762.
Peer Reviewed verified by ORBi

Soubhye, J., Aldib, I., Delporte, C., Prévost, M., Dufrasne, F., & Van Antwerpen, P. (10 October 2016). Myeloperoxidase as a Target for Treatment of Inflammatory Syndromes: Mechanisms and Structure Activity Relationships of Inhibitors. Current Medicinal Chemistry, 23 (35), 3975-4008.
Peer Reviewed verified by ORBi

Soubhye, J., Meyer, F., Furtmuller, P. G., Obinger, C., Dufrasne, F., & Van Antwerpen, P. (2016). Characterization of chemical features of potent myeloperoxidase inhibitors. Future Medicinal Chemistry.
Peer Reviewed verified by ORBi

Sa, J., Czapla-Masztafiak, J., Lipiec, E., Kayser, Y., Fernandes, D. L. A., Szlachetko, J., Dufrasne, F., & Berger, G. (08 February 2016). Resonant X-ray emission spectroscopy of platinum(ii) anticancer complexes. Analyst, 141 (4), 1226-1232.
Peer Reviewed verified by ORBi

Sa, J., Czapla-Masztafiak, J., Lipiec, E., Kwiatek, W., Kayser, Y., Wood, B., Deacon, G. B., Berger, G., Dufrasne, F., Fernandes, D. L. A., & Szlachetko, J. (01 September 2015). The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules. Drug Discovery Today. Technologies, 16, 1-6.

Soubhye, J., Chikh Alard, I., Van Antwerpen, P., & Dufrasne, F. (01 July 2015). Type 2 17-beta Hydroxysteroid Dehydrogenase as a Novel Target for Treatment of Osteoporosis. Future Medicinal Chemistry, 7 (11), 1431-1456.

Berger, G., Fusaro, L., Czapla-Masztafiak, J., Lipiec, E., Szlachetko, J., Kayser, Y., Fernandes, D. L. A., Sa, J., Dufrasne, F., & Bombard, S. (01 July 2015). Insights into the structure-activity relationships of chiral 1,2-diaminophenylalkane platinum(II) anticancer derivatives. Journal of Biological Inorganic Chemistry, 20 (5), 841-853.

Soubhye, J., Prévost, M., Elfving, B., Gelbcke, M., Podrecca, M., Conotte, R., Colet, J.-M., Furtmuller, P. G., Delporte, C., Rousseau, A., Vanhaeverbeek, M., Nève, J., Obinger, C., Zouaoui Boudjeltia, K., Van Antwerpen, P., & Dufrasne, F. (2014). Hybrid Molecules Inhibiting Myeloperoxidase Activity and Serotonin Reuptake: A Possible New Approach of Major Depressive Disorders with Inflammatory Syndrome. Journal of Pharmacy and Pharmacology.

Berger, G., Leclerqz, H., Derenne, A., Gelbcke, M., Goormaghtigh, E., Nève, J., Mathieu, V., & Dufrasne, F. (01 July 2014). Synthesis and in vitro characterization of platinum(II) anticancer coordinates using FTIR spectroscopy and NCI COMPARE: A fast method for new compound discovery. Bioorganic and Medicinal Chemistry, 22 (13), 3527-3536.

Tourrel, F., Kwetieu de Lendeu, P., Abily-Donval, L., Chollat, C., Marret, S., Dufrasne, F., Compagnon, P., Ramdani, Y., Dureuil, B., Laudenbach, V., Gonzalez, B., & Jégou, S. (2014). Remifentanil anti-apoptotic Effect on the Immature Mouse Brain: an ex vivo study. Anesthesia and Analgesia.

Berger, G., Leclerqz, H., Derenne, A., Goormaghtigh, E., Nève, J., Mathieu, V., & Dufrasne, F. (22 July 2013). Synthesis and in vitro characterization of anticancer platinum(II) coordinates: NCI Compare and FTIR spectroscopy for drug candidate profiling. Poster session presented at International Conference of BioInorganic Chemistry, ICBIC 16, Grenoble, France.

Moreno Banuls, L., Urban, E., Gelbcke, M., Dufrasne, F., Kopp, B., Kiss, R., & Zehl, M. (2013). Structure-Activity Relationship Analysis of Bufadienolide-Induced in Vitro Growth Inhibitory Effects on Mouse and Human Cancer Cells. Journal of Natural Products.
Peer Reviewed verified by ORBi

Soubhye, J., Aldib, I., Elfving, B., Gelbcke, M., Furtmuller, P. G., Podrecca, M., Conotte, R., Colet, J.-M., Rousseau, A., Reyé, F., Sarakbi, A., Vanhaeverbeek, M., Kauffmann, J.-M., Obinger, C., Nève, J., Prevost, M., Zouaoui Boudjeltia, K., Dufrasne, F., & Van Antwerpen, P. (23 May 2013). Design, Synthesis, and Structure-Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors. Journal of Medicinal Chemistry, 56 (10), 3943-3958. doi:10.1021/jm4001538
Peer Reviewed verified by ORBi

Berger, G., Gelbcke, M., Cauët, E., Luhmer, M., Nève, J., & Dufrasne, F. (06 February 2013). 25. Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds. Tetrahedron Letters, 54 (6), 545-548.

Mijatovic, T., Dufrasne, F., & Kiss, R. (23 November 2012). Cardiotonic Steroids-Mediated Targeting of the Na+/K+-ATPase to Combat Chemoresistant Cancers. Current Medicinal Chemistry, 19 (5), 627-646.
Peer Reviewed verified by ORBi

Ionescu, A., Dufrasne, F., Gelbcke, M., Jabin, I., Kiss, R., & lamoral-thys, D. (01 November 2012). DYRK1A kinase inhibitors with emphasis on cancer. Mini Reviews in Medicinal Chemistry, 12 (13), 1315-1329.
Peer Reviewed verified by ORBi

Aldib, I., Soubhye, J., Zouaoui Boudjeltia, K., Vanhaeverbeek, M., Rousseau, A., Furtmuller, P. G., Obinger, C., Dufrasne, F., Nève, J., Van Antwerpen, P., & Prevost, M. (23 August 2012). Evaluation of New Scaffolds of Myeloperoxidase Inhibitors by Rational Design Combined with High-Throughput Virtual Screening. Journal of Medicinal Chemistry, 55 (16), 7208-7218.

Mijatovic, T., Dufrasne, F., & Kiss, R. (01 March 2012). Na+/K+-ATPase and Cancer. Pharmaceutical Patent Analyst, 1 (1), 91-106.
Peer Reviewed verified by ORBi

Dufrasne, F., Gelbcke, M., Nève, J., Kiss, R., & Kraus, J.-L. (17 September 2011). Quinone methides and their prodrugs: a subtle equilibrium between cancer promotion, prevention, and cure. Current Medicinal Chemistry, 18 (26), 3995-4011.
Peer Reviewed verified by ORBi

Le Calvé, B., Lallemand, B., Perrone, C., Lenglet, G., Depauw, S., Van Goietsenoven, G., Bury, M., Vurro, M., Herphelin, F., Andolphi, A., Zonno, M. C., Mathieu, V., Dufrasne, F., Van Antwerpen, P., Poumay, Y., David-Cordonnier, M.-H., Evidente, A., & Kiss, R. (12 April 2011). In vitro anticancer activity, toxicity and structure-activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii. Toxicology and Applied Pharmacology, 254 (1), 8-17.
Peer Reviewed verified by ORBi

Soubhye, J., Dufrasne, F., & Van Antwerpen, P. (02 December 2010). Preparation of 3-alkyl-5-fluoroindole derivatives as myeloperoxidase inhibitors.

Soubhye, J., Prevost, M., Van Antwerpen, P., Zouaoui Boudjeltia, K., Rousseau, A., Furtmuller, P. G., Obinger, C., Vanhaeverbeek, M., Ducobu, J., Nève, J., Gelbcke, M., & Dufrasne, F. (22 October 2010). Structure-Based Design, Synthesis, and Pharmacological Evaluation of 3-(Aminoalkyl)-5-fluoroindoles as Myeloperoxidase Inhibitors. Journal of Medicinal Chemistry, 53 (24).
Peer Reviewed verified by ORBi

Berger, G., Gasper, R., lamoral-thys, D., Wellner, A., Gelbcke, M., Gust, R., Nève, J., Kiss, R., Goormaghtigh, E., & Dufrasne, F. (05 August 2010). Fourier Transform Infrared (FTIR) spectroscopy to monitor the cellular impact of newly synthesized platinum derivatives. International Journal of Oncology, 37 (3).
Peer Reviewed verified by ORBi

lamoral-thys, D., Pottier, L., Kerff, F., Dufrasne, F., Proutiere, F., Wauthoz, N., Neven, P., Ingrassia, L., Van Antwerpen, P., Lefranc, F., Gelbcke, M., Pirotte, B., Kraus, J.-L., Nève, J., Kornienko, A., Kiss, R., & Dubois, J. (22 June 2010). Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli. Bioorganic and Medicinal Chemistry, 18 (11).
Peer Reviewed verified by ORBi

Kiss, R., Dubois, J., Nève, J., lamoral-thys, D., Dufrasne, F., & Pottier, L. (22 April 2010). Divanilloyl and trivanilloyl derivatives as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases.

lamoral-thys, D., Pottier, L., Dufrasne, F., Nève, J., Dubois, J., Kiss, R., Kornienko, A., & Ingrassia, L. (10 April 2010). Natural polyphenols that display anticancer properties through inhibition of kinase activity. Frontiers in Neuroscience, 13 (9), 812-825.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Zouaoui Boudjeltia, K., Dufrasne, F., Babar, S., Moreau, P., Moguilevsky, N., Prevost, M., Vanhaeverbeek, M., Nève, J., & Ducobu, J. (2008). Tryptamine derivatives inhibit the myeloperoxidase-dependent LDL oxidation. Atherosclerosis. Supplements.
Peer Reviewed verified by ORBi

Dufrasne, F., & Galanski, M. (17 November 2007). The relation between stereochemistry and biological activity of platinum(II) complexes chelated with chiral diamine ligands: an intricate problem. Current Pharmaceutical Design, 13 (27), 2781-2794.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Moreau, P., Zouaoui Boudjeltia, K., Babar, S., Dufrasne, F., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Nève, J. (2007). Development and validation of a screening procedure for the assessment of inhibition using a recombinant enzyme. Talanta.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Prevost, M., Zouaoui Boudjeltia, K., Babar, S., Lessgyer, I., Moreau, P., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Dufrasne, F. (07 November 2007). Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification. Bioorganic and Medicinal Chemistry, 16 (4), 1702-1720.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Zouaoui Boudjeltia, K., Dufrasne, F., Lessgyer, I., Babar, S., Moreau, P., Moguilevsky, N., Prevost, M., Nève, J., & Ducobu, J. (12 July 2007). Inhibition of the MPO/H2O2/chloride dependent LDL oxidation assessed by in vitro, elisa and cell tests. Atherosclerosis. Supplements, 8 (1), 88-88.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Dufrasne, F., Lequeux, M., Zouaoui Boudjeltia, K., Lessgyer, I., Babar, S., Moreau, P., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Nève, J. (12 June 2007). Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: Flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid. European Journal of Pharmacology, 570 (1-3), 235-243.
Peer Reviewed verified by ORBi

Dullin, A., Dufrasne, F., Gelbcke, M., & Gust, R. (15 May 2006). Synthesis and cytotoxicity of enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)-3-methylbutane]platinum(II) complexes. ChemMedChem, 1 (6), 644-653.
Peer Reviewed verified by ORBi

Dufrasne, F., Gelbcke, M., & Galanski, M. (18 January 2006). Signal separation and determination of the enantiomeric purity of primary amines with 1R-(-)-myrtenal - a 13C NMR study. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 65 (3-4), 869-873.
Peer Reviewed verified by ORBi

Guntz, E., Dumont, H., Roussel, C., Gall, D., Dufrasne, F., Blum, D., Schiffmann, S., & Sosnowski, M. (07 March 2005). Effect of remifentanyl on NMDA receptor. An electrophysiological study in rat spinal cord. Anesthesiology, 102 (6), 1235-1241.
Peer Reviewed verified by ORBi

Dufrasne, F., Gelbcke, M., & Nève, J. (26 January 2005). Synthesis of 1,2-Diamino-1-phenylpropane Diastereoisomers from u-N-Trifluoroacetyl-2-amino-1-phenylpropan-1-ol. Monatshefte für Chemie, 136 (5), 739-744.
Peer Reviewed verified by ORBi

Dullin, A., Dufrasne, F., Gelbcke, M., & Gust, R. (13 December 2004). Enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)butane]platinum(II) complexes: Synthesis and antitumor activity against MCF-7 and MDA-MB 231 breast cancer and LnCaP/FGC prostate cancer cell lines. Archiv der Pharmazie, 337 (12), 654-667.
Peer reviewed

Dufrasne, F., Gelbcke, M., Schurr, B., & Gust, R. (13 December 2004). Synthesis and Antitumor Activity of Enantiomerically Pure [1,2-Diamino-1-(4-fluorophenyl)propane]-dichloroplatinum(II) Complexes. Archiv der Pharmazie, 335 (5), 229-339.
Peer reviewed

Dufrasne, F., Gelbcke, M., & Nève, J. (04 February 2003). 1H-nuclear magnetic resonance determination of the enantiomeric purity of aliphatic primary amines, beta-aminoalcohols, beta-diamines and alpha-amino-acids with (1R)-(-)-myrtenal: scope and limitations. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 59 (6), 1239-1245.
Peer Reviewed verified by ORBi

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