Profil

Zouaoui Boudjeltia Karim

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service du Doyen de la Faculté de Médecine et Pharmacie

Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > FMP - Service du Doyen


Main Research Fields
Zoology
Pharmacy, pharmacology & toxicology
General & internal medicine
Cardiovascular & respiratory systems
Chemistry
Main Keywords
anti-inflammatory; beta-carboline alkaloids; docking; HPLC; myeloperoxidase;
Main Unit & Research Centers
BIOSYS - Biosys
Main Co-authors
Legrand, Alexandre 
Tassin, Alexandra 
Van Antwerpen, P.
Conotte, Stéphanie 
Dufrasne, François 

Publications (total 36)

The most cited
53 citations (SCOPUS)
Bensalem, S., Soubhye, J., Aldib, I., Bournine, L., Nguyen, A.-T., Vanhaeverbeek, M., Rousseau, A., Zouaoui Boudjeltia, K., Sarakbi, A., Kauffmann, J.-M., Nève, J., Prévost, M., Stévigny, C., Maiza-Benabdesselam, F., Bedjou, F., Van Antwerpen, P., & Duez, P. (16 April 2014). Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae). Journal of Ethnopharmacology, 154 (2), 361-369. doi:10.1016/j.jep.2014.03.070 https://hdl.handle.net/20.500.12907/7454

Conotte, S., Tassin, A., Delpierre, A., Zouaoui Boudjeltia, K., & Legrand, A. (31 January 2020). Contribution of oxidative stress to muscle dysfunction associated to chronic intermittent hypoxia : an interventional study in a murine model. Poster session presented at 14th meeting of the FRS-FNRS Contact group on Oxidative Processes and Antioxidants, Mons, Belgium.

Pierard, M., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (11 December 2018). Effect of hypoxia on adiponectin pathway in murine and cellular models: which involvement in COPD-associated cardiovascular risk ? Poster session presented at Europhysiology, London, United Kingdom.

Carlier, S., Saussez, J., Scalia, A., Chodzynski, K., Nishio, S., Thayse, K., Brunner, P., Zouaoui Boudjeltia, K., & Coussement, G. (10 March 2018). IN VIVO, IN VITRO AND IN SILICO COMPARISON OF TWO DEVICES TO MEASURE FRACTIONAL FLOW RESERVE. Paper presented at AMERICAN COLLEGE OF CARDIOLOGY, Orlando, United States - Florida.

Soubhye, J., Chikh Alard, I., Aldib, I., Prévost, M., Gelbcke, M., De Carvalho, A.-L., Furtmuller, P. G., Obinger, C., Flemming, J., Tadrent, S., Meyer, F., Rousseau, A., Nève, J., Mathieu, V., Zouaoui Boudjeltia, K., Dufrasne, F., & Van Antwerpen, P. (03 July 2017). Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors using Virtual Screening Procedure. Journal of Medicinal Chemistry, 60 (15), 6563-6586.
Peer Reviewed verified by ORBi

Soubhye, J., Gelbcke, M., Van Antwerpen, P., Dufrasne, F., Boufadi, Y., Nève, J., Furtmuller, P. G., Obinger, C., Zouaoui Boudjeltia, K., & Meyer, F. (02 December 2016). From dynamic combinatorial chemistry to in vivo evaluation of reversible and irreversible myeloperoxidase inhibitors. ACS Medicinal Chemistry Letters, 8 (2), 206-210.
Peer reviewed

Pierard, M., Conotte, S., Tassin, A., Boutry, S., Uzureau, P., Zouaoui Boudjeltia, K., & Legrand, A. (2016). Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice. Nutrition and Metabolism. doi:10.1186/s12986-016-0138-2
Peer Reviewed verified by ORBi

Aldib, I., Gelbcke, M., Soubhye, J., Prévost, M., Furtmuller, P. G., Obinger, C., Elfving, B., Chikh Alard, I., Roos, G., Delporte, C., Berger, G., Dufour, D., Zouaoui Boudjeltia, K., Nève, J., Dufrasne, F., & Van Antwerpen, P. (10 November 2016). Novel bis-arylalkylamines as myeloperoxidase inhibitors: Design, synthesis, and structure-activity relationship study. European Journal of Medicinal Chemistry, 123, 746-762.
Peer Reviewed verified by ORBi

Pierard, M., Delpierre, A., Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (30 June 2016). Modulations of adiponectin pathway inuced by hypoxia in murine and cellular models. Poster session presented at Federation of European Physiological Societies, Paris, France.

Conotte, S., Tassin, A., Nuyens, V., Zouaoui Boudjeltia, K., & Legrand, A. (2016). effect of chronic intermittent hypoxia on muscle function in a mouse model of obstructive sleep apnea. Paper presented at Federation of European Physiological Societies, Paris, France.

Pierard, M., Delpierre, A., Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (2016). Modulations of adiponectin pathway induced by hypoxia in murin and cellular models. Paper presented at Federation of European Physiological Societies, Paris, France.

Conotte, S., Tassin, A., Nuyens, V., Zouaoui Boudjeltia, K., & Legrand, A. (28 June 2016). effect of chronic intermittent hypoxia on muscle function in a mouse model of obstructive sleep apnea. Poster session presented at Federation of European Physiological Societies, Paris, France.

Pierard, M., Delpierre, A., Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (18 May 2016). Composante hypoxémique de la BPCO : quel impact sur les ADIPO-récepteurs ? Poster session presented at MDC 2016 Valenciennes, Valenciennes, France.

Conotte, S., Tassin, A., Nuyens, V., Zouaoui Boudjeltia, K., & Legrand, A. (22 April 2016). effect of chronic intermittent hypoxia on muscle function in a mouse model of obstructive sleep apnea. Poster session presented at 12th meeting of the FRS-FNRS Contact Group on oxidative stress and antioxydants : New Frontiers in Oxidative Stress and Redox Regulation, Louvain-la-Neuve, Belgium.

Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (06 November 2015). Cardiovascular alterations associated to intermittent hypoxia in a mouse model of obstructive sleep apnea (OSA). Poster session presented at autumn meeting Belgian Society of Physiology and Pharmacology, Bruxelles, Belgium.

Pierard, M., Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (06 November 2015). Effect of continuous and intermittent hypoxia on adiponectin multimeric forms and muscle receptors in mice. Poster session presented at autumn meeting Belgian Society of Physiology and Pharmacology, Bruxelles, Belgium.

Ribeiro de Sousa, D., Vallecilla, C., CHODZYNSKI, K., Corredor Jerez, R., Malaspinas, O., EKER, O. F., Ouared, R., Vanhamme, L., Legrand, A., Chopard, B., Courbebaisse, G., & Zouaoui Boudjeltia, K. (27 July 2015). Determination of a shear rate threshold for thrombus formation in intracranial aneurysms. Journal of NeuroInterventional Surgery, 0, 1-6. doi:10.1136/neurintsurg-2015-011737
Peer Reviewed verified by ORBi

Pierard, M., Conotte, S., Boutry, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (12 May 2015). Effet de l'exercice physique sur l'adiponectine dans un modèle murin de syndrome métabolique. Poster session presented at Journée scientifique du Pôle hainuyer (JSPH1), Mons, Belgium.

Conotte, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (10 March 2015). Pathophysiological effects of a well-controlled exposure to intermittent hypoxia in mice : validation of a sleep apnea model. Poster session presented at 8ème édition de la Matinée des Chercheurs 2015 (MdC2015), Mons, Belgium.

Pahulycz, L., Tassin, A., Conotte, S., Zouaoui Boudjeltia, K., Piagnerelli, M., & Legrand, A. (10 March 2015). Impact of hyperoxia in a murine model of intensive care unit myopathy. Poster session presented at 8ème édition de la Matinée des Chercheurs 2015 (MdC2015), Mons, Belgium.

Pahulycz, L., Piagnerelli, M., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (23 January 2015). Impact de l'hyperoxie sur la myopathie dans un modèle murin de sepsis. Poster session presented at 43e Congrès International de la SRLF (Société de Réanimation de Langue Française), Paris, France.

Soubhye, J., Prévost, M., Elfving, B., Gelbcke, M., Podrecca, M., Conotte, R., Colet, J.-M., Furtmuller, P. G., Delporte, C., Rousseau, A., Vanhaeverbeek, M., Nève, J., Obinger, C., Zouaoui Boudjeltia, K., Van Antwerpen, P., & Dufrasne, F. (2014). Hybrid Molecules Inhibiting Myeloperoxidase Activity and Serotonin Reuptake: A Possible New Approach of Major Depressive Disorders with Inflammatory Syndrome. Journal of Pharmacy and Pharmacology.

Bensalem, S., Soubhye, J., Aldib, I., Bournine, L., Nguyen, A.-T., Vanhaeverbeek, M., Rousseau, A., Zouaoui Boudjeltia, K., Sarakbi, A., Kauffmann, J.-M., Nève, J., Prévost, M., Stévigny, C., Maiza-Benabdesselam, F., Bedjou, F., Van Antwerpen, P., & Duez, P. (16 April 2014). Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae). Journal of Ethnopharmacology, 154 (2), 361-369. doi:10.1016/j.jep.2014.03.070
Peer Reviewed verified by ORBi

Conotte, S., Colet, J.-M., Zouaoui Boudjeltia, K., & Legrand, A. (05 April 2014). Metabonomic profiling of intermittent hypoxia in a mouse model. Paper presented at PhysPhar Meeting, Maastricht, Netherlands.

Pierard, M., Conotte, S., Boutry, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (05 April 2014). Effect of exercise training on adiponectin multimeric forms in a mouse model of metabolic syndrome. Paper presented at PhysPhar Meeting, Maastricht, Netherlands.

Pierard, M., Conotte, S., Boutry, S., Tassin, A., Zouaoui Boudjeltia, K., & Legrand, A. (04 April 2014). Effect of exercise training on adiponectin multimeric forms in a mouse model of metabolic syndrome. Poster session presented at PhysPhar Meeting, Maastricht, Netherlands.

Soubhye, J., Aldib, I., Elfving, B., Gelbcke, M., Furtmuller, P. G., Podrecca, M., Conotte, R., Colet, J.-M., Rousseau, A., Reyé, F., Sarakbi, A., Vanhaeverbeek, M., Kauffmann, J.-M., Obinger, C., Nève, J., Prevost, M., Zouaoui Boudjeltia, K., Dufrasne, F., & Van Antwerpen, P. (23 May 2013). Design, Synthesis, and Structure-Activity Relationship Studies of Novel 3-Alkylindole Derivatives as Selective and Highly Potent Myeloperoxidase Inhibitors. Journal of Medicinal Chemistry, 56 (10), 3943-3958. doi:10.1021/jm4001538
Peer Reviewed verified by ORBi

Chodzynski, K., Conotte, S., Vanhamme, L., Van Antwerpen, P., Kerkhofs, M., Legros, J. L., Vanhaeverbeek, M., Van Meerhaeghe, A., Coussement, G., Zouaoui Boudjeltia, K., & Legrand, A. (02 April 2013). A new device to mimic intermittent hypoxia in mice. PLoS ONE, 8 (4), 1-10.
Peer reviewed

Aldib, I., Soubhye, J., Zouaoui Boudjeltia, K., Vanhaeverbeek, M., Rousseau, A., Furtmuller, P. G., Obinger, C., Dufrasne, F., Nève, J., Van Antwerpen, P., & Prevost, M. (23 August 2012). Evaluation of New Scaffolds of Myeloperoxidase Inhibitors by Rational Design Combined with High-Throughput Virtual Screening. Journal of Medicinal Chemistry, 55 (16), 7208-7218.

Roumeguère, T., Delrée, P., Van Antwerpen, P., Rorive, S., Vanhamme, L., De La Kethulle De Ryhove, L., serteyn, D., Wespes, E., Vanhaeverbeek, M., & Zouaoui Boudjeltia, K. (07 July 2011). Intriguing location of myeloperoxidase in the prostate: A preliminary immunohistochemical study. Prostate, 72 (5), 507-13. doi:10.1002/pros.21452
Peer Reviewed verified by ORBi

Soubhye, J., Prevost, M., Van Antwerpen, P., Zouaoui Boudjeltia, K., Rousseau, A., Furtmuller, P. G., Obinger, C., Vanhaeverbeek, M., Ducobu, J., Nève, J., Gelbcke, M., & Dufrasne, F. (22 October 2010). Structure-Based Design, Synthesis, and Pharmacological Evaluation of 3-(Aminoalkyl)-5-fluoroindoles as Myeloperoxidase Inhibitors. Journal of Medicinal Chemistry, 53 (24).
Peer Reviewed verified by ORBi

Zouaoui Boudjeltia, K., Van Antwerpen, P., Chodzynski, K., & Coussement, G. (2010). Modélisation de l'endothélium vasculaire. Paper presented at VIème Symposium 'Lipides et athérosclérose', Mons, Unknown/unspecified.

Van Antwerpen, P., Zouaoui Boudjeltia, K., Dufrasne, F., Babar, S., Moreau, P., Moguilevsky, N., Prevost, M., Vanhaeverbeek, M., Nève, J., & Ducobu, J. (2008). Tryptamine derivatives inhibit the myeloperoxidase-dependent LDL oxidation. Atherosclerosis. Supplements.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Moreau, P., Zouaoui Boudjeltia, K., Babar, S., Dufrasne, F., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Nève, J. (2007). Development and validation of a screening procedure for the assessment of inhibition using a recombinant enzyme. Talanta.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Prevost, M., Zouaoui Boudjeltia, K., Babar, S., Lessgyer, I., Moreau, P., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Dufrasne, F. (07 November 2007). Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification. Bioorganic and Medicinal Chemistry, 16 (4), 1702-1720.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Zouaoui Boudjeltia, K., Dufrasne, F., Lessgyer, I., Babar, S., Moreau, P., Moguilevsky, N., Prevost, M., Nève, J., & Ducobu, J. (12 July 2007). Inhibition of the MPO/H2O2/chloride dependent LDL oxidation assessed by in vitro, elisa and cell tests. Atherosclerosis. Supplements, 8 (1), 88-88.
Peer Reviewed verified by ORBi

Van Antwerpen, P., Dufrasne, F., Lequeux, M., Zouaoui Boudjeltia, K., Lessgyer, I., Babar, S., Moreau, P., Moguilevsky, N., Vanhaeverbeek, M., Ducobu, J., & Nève, J. (12 June 2007). Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs: Flufenamic acid and its 5-chloro-derivative directly interact with a recombinant human myeloperoxidase to inhibit the synthesis of hypochlorous acid. European Journal of Pharmacology, 570 (1-3), 235-243.
Peer Reviewed verified by ORBi

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