Optimal control for fermentative production of fructo-oligosaccharides in fed-batch  bioreactor

Schorsch, Julien; Castro, Cristiana; Couto, Luís; Nobre, Clarisse; Kinnaert, Michel

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Optimal control for fermentative production of fructo-oligosaccharides in fed-batch bioreactor

Schorsch, Julien; Castro, Cristiana; Couto, Luís et al.

2019 • In Journal of Process Control

Peer Reviewed verified by ORBi

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https://hdl.handle.net/20.500.12907/18115

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Abstract :

[en] The production of high-content fructo-oligosaccharides by fermentation in a fed-batch bioreactor is considered. Fed-batch scenario allows to reduce inhibition mechanisms caused by the presence of by-products, such as glucose, while maximizing biomass production. The determination of the feed flow rate profile that maximizes the concentration of fructo-oligosaccharides is performed by resorting to the maximum principle of Pontryagin. The optimization procedure takes into account inequality constraints on the state and control variables and allows the determination of the unspecified final fermentation time corresponding to maximal fructo-oligosaccharides content. The performance of the approach is demonstrated by simulations in the case of fructo-oligosaccharide production by Aspergillus sp.

Disciplines :

Chemical engineering
Biotechnology

Author, co-author :

Schorsch, Julien

Castro, Cristiana ; Université de Mons > Faculté Polytechnique > Génie des Procédés chimiques et biochimiques

Couto, Luís

Nobre, Clarisse

Kinnaert, Michel

Language :

English

Title :

Optimal control for fermentative production of fructo-oligosaccharides in fed-batch bioreactor

Publication date :

01 June 2019

Journal title :

Journal of Process Control

ISSN :

0959-1524

Publisher :

Butterworth Scientific, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

F505 - Génie des Procédés chimiques et biochimiques
F506 - Thermodynamique, Physique mathématiques

Research institute :

R100 - Institut des Biosciences

Available on ORBi UMONS :

since 12 December 2019

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