Adler L. S., (2000). The ecological significance of toxic nectar. Oikos 91 409–420. 10.1034/j.1600-0706.2000.910301.x 11841302
Alaux C., Ducloz F., Crauser D., Le Conte Y., (2010). Diet effects on honeybee immunocompetence. Biol. Let. 6 562–565. 10.1098/rsbl.2009.0986 20089536
Aličić D., Šubarić D., Jašić M., Pašalić H., Ačkar Ð, (2014). Antioxidant properties of pollen. Hrana u Zdravlju i Bolesti Znanstveno-struèni Èasopis za Nutricionizam i Dijetetiku 3 6–12.
Ares A. M., Nozal M. J., Bernal J., (2015). Development and validation of a liquid chromatography-tandem mass spectrometry method to determine intact glucosinolates in bee pollen. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1000 49–56. 10.1016/j.jchromb.2015.07.017 26209770
Arnold S. E. J., Idrovo M. E. P., Arias L. J. L., Belmain S. R., Stevenson P. C., (2014). Herbivore defence compounds occur in pollen and reduce bumblebee colony fitness. J. Chem. Ecol. 40 878–881. 10.1007/s10886-014-0467-4 24952086
Ayestaran A., Giurfa M., de Brito Sanchez M. G., (2010). Toxic but drank: gustatory aversive compounds induce post-ingestional malaise in harnessed honeybees. PLoS One 5:e15000. 10.1371/journal.pone.0015000 21060877
Baracchi D., Brown M. F. J., Chittka L., (2015). Behavioural evidence for self-medication in bumblebees? F1000 Res. 4:73. 10.12688/f1000research.6262.2 25949807
Beaulieu M., Schaefer H. M., (2013). Rethinking the role of dietary antioxidants through the lens of self-medication. Anim. Behav. 86 17–24. 10.1016/j.anbehav.2013.05.022
Billiet A., Meeus I., Van Nieuwerburgh F., Deforce D., Wäckers F., Smagghe G., (2015). Impact of sugar syrup and pollen diet on the bacterial diversity in the gut of indoor-reared bumblebees (Bombus terrestris). Apidologie 47 548–560. 10.1007/s13592-015-0399-1
Bonilla-Rosso G., Engel P., (2018). Functional roles and metabolic niches in the honey bee gut microbiota. Curr. Opin. Microbiol. 43 69–76. 10.1016/j.mib.2017.12.009 29309997
Boulogne I., Petit F., Ozier-Lafontaine H., Desfontaines L., Loranger-Merciris G., (2012). Insecticidal and antifungal chemicals produced by plants: a review. Environ. Chem. Lett. 10 325–347. 10.1007/s10311-012-0359-1
Brochu K. K., van Dyke M. T., Milano N. J., Petersen J. D., McArt S. H., Nault B. A., et al. (2020). Pollen defenses negatively impact foraging and fitness in a generalist bee (Bombus impatiens: Apidae). Sci. Rep. 10:3112.
Brodschneider R., Crailsheim K., (2010). Nutrition and health in honey bees. Apidologie 41 278–294. 10.1051/apido/2010012
Brown C., Keith S., (1987). Chemistry at the Solanaceae/Ithomiinae Interface. Ann. Mo. Bot. Gard. 74 359–397. 10.2307/2399406
Burden C. M., Morgan M. O., Hladun K. R., Amdam G. V., Trumble J. J., Smith B. H., (2019). Acute sublethal exposure to toxic heavy metals alters honey bee (Apis mellifera) feeding behavior. Sci. Rep. 9:4253.
Calatayud P. A., Rabhé Y., (2013). “Chapitre 6. Le tube digestif des insects,” in Interactions Insectes-Plantes, eds Sauvion N., Paul-André C., Thiéry D., Marion-Pol F., (Marseille: IRD).
Cane J. H., (2016). Adult pollen diet essential for egg maturation by a solitary Osmia bee. J. Insect Physiol. 95 105–109. 10.1016/j.jinsphys.2016.09.011 27659135
Cane J. H., Dobson H. E. M., Boyer B., (2016). Timing and size of daily pollen meals eaten by adult females of a solitary bee (Nomia melanderi) (Apiformes: Halictidae). Apidologie 48 17–30. 10.1007/s13592-016-0444-8
Cane J. H., Sipes S., (2006). “Characterizing floral specialization by bees: analytical methods and a revised lexicon for oligolecty,” in Plant-Pollinator Interactions: from Specialization to Generalization, eds Waser N. M., Ollerton J., (Chicago, IL: The University of Chicago Press), 99–112.
Chowański S., Adamski Z., Marciniak P., Rosiński G., Büyükgüzel E., Büyükgüzel K., et al. (2016). A Review of bioinsecticidal activity of Solanaceae alkaloids. Toxins 8:60. 10.3390/toxins8030060 26938561
Compean K. L., Ynalvez R. A., (2014). Antimicrobial activity of plant secondary metabolites: a review. Res. J. Med. Plant 8 204–213. 10.3923/rjmp.2014.204.213
Conn E. E., (1978). “Cyanogenesis, the production of hydrogen cyanide, by plants,” in Effects of Poisonous Plants on Livestock, eds Keeler R. F., Van kampen K. R., James L. F., (New York, NY: Academic Press), 301–310. 10.1016/b978-0-12-403250-7.50035-2
Cook D., Manson J. S., Gardner D. R., Welch K. D., Irwin R. E., (2013). Norditerpene alkaloid concentrations in tissues and floral rewards of larkspurs and impacts on pollinators. Biochem. Syst. Ecol. 48 123–131. 10.1016/j.bse.2012.11.015
Dag A., Zipori I., Pleser Y., (2006). Using bumblebees to improve almond pollination by the honeybee. J. Apic. Res. 45 215–216. 10.3896/ibra.1.45.4.08
Day S., Beyer R., Mercer A., Ogden S., (1990). The nutrient composition of honeybee collected pollen in Otago. N. Z. J. Apic. Res. 29 138–146. 10.1080/00218839.1990.11101210
de Brito Sanchez M. G., (2011). Taste perception in honey bees. Chem. Senses 36 675–692. 10.1093/chemse/bjr040 21622601
de Carvalho A. C. P., Message D., (2004). A scientific note on the toxic pollen of Stryphnodendron polyphyllum (Fabaceae, Mimosoideae) which causes sacbrood-like symptoms. Apidologie 35 89–90. 10.1051/apido:2003059
de Roode J. C., Lefèvre T., Hunter M. D., (2013). Ecology. Self-medication in animals. Science 340 150–151. 10.1126/science.1235824 23580516
DeGrandi-Hoffman G., Chen Y., Huang E., Huang M. H., (2010). The effect of diet on protein concentration, hypopharyngeal gland development and virus load in worker honey bees (Apis mellifera L.). J. Insect Physiol. 56 1184–1191. 10.1016/j.jinsphys.2010.03.017 20346950
Detzel A., Wink M., (1993). Attraction, deterrence or intoxication of bees (Apis mellifera) by plant allelochemicals. Chemoecology 4 8–18. 10.1007/bf01245891
Di Pasquale G., Salignon M., Le Conte Y., Belzunces L. P., Decourtye A., Kretzschmar A., et al. (2013). Influence of pollen nutrition on honey bee health: do pollen quality and diversity matter? PLoS One 8:e72016. 10.1371/journal.pone.0072016 23940803
Dicks L., Breeze T., Ngo H., Senapathi D., An J., Aizen M., et al. (2020). A global assessment of drivers and risks associated with pollinator decline. Res. Sq. 10.21203/rs.3.rs-90439/v1
Dobson H. E. M., Bergström G., (2000). The ecology and evolution of pollen odors. Plant Syst. Evol. 222 63–87. 10.1007/978-3-7091-6306-1_4
Dobson H. E. M., Peng Y. S., (1997). Digestion of pollen components by larvae of the flower- specialist bee Chelostoma florisomne (Hymenoptera: Megachilidae). J. Insect Physiol. 43 89–100. 10.1016/s0022-1910(96)00024-8
Dolezal A. G., Carrillo-Tripp J., Judd T. M., Miller W. A., Bonning B. C., Toth A. L., (2019). Interacting stressors matter: diet quality and virus infection in honeybee health. R. Soc. Open Sci. 6:181803. 10.1098/rsos.181803 30891288
Eckhardt M., Haider M., Dorn S., Müller A., (2014). Pollen mixing in pollen generalist solitary bees: a possible strategy to complement or mitigate unfavourable pollen properties? J. Anim. Ecol. 83 588–597. 10.1111/1365-2656.12168 24164651
Engel P., Moran N. A., (2013). The gut microbiota of insects–diversity in structure and function. FEMS Microbiol. Rev. 37 699–735. 10.1111/1574-6976.12025 23692388
Erickson M., Feeny P., (1974). Sinigrin: a chemical barrier to the black swallowtail butterfly, Papilio polyxenes. Ecology 55 103–111. 10.2307/1934622
Feldhaar H., (2011). Bacterial symbionts as mediators of ecologically important traits of insects hosts. Ecol. Entomol. 36 533–543. 10.1111/j.1365-2311.2011.01318.x
Forbey J. S., Harvey A. L., Huffman M. A., Provenza F. D., Sullivan R., Tasdemir D., (2009). Exploitation of secondary metabolites by animals: a response to homeostatic challenge. Integr. Comp. Biol. 49 314–328. 10.1093/icb/icp046 21665822
Fraenkel G. S., (1959). The raison d’être of secondary plant substances. Science 129 1466–1470. 10.1126/science.129.3361.1466 13658975
Free J. B., (1993). Insect Pollination of Crops, 2nd Edn. London: Academic Press, 768.
French A. S., Sellier M. J., Ali Agha M., Guigue A., Chabaud M. A., Reeb P. D., et al. (2015). Dual mechanism for bitter avoidance in Drosophila. J. Neurosci. 35 3990–4004. 10.1523/jneurosci.1312-14.2015 25740527
Frisch T., Motawia M. S., Olsen C. E., Agerbirk N., Møller B. L., Bjarnholt N., (2015). Diversified glucosinolate metabolism: biosynthesis of hydrogen cyanide and of the hydroxynitrile glucoside alliarinoside in relation to sinigrin metabolism in Alliaria petiolata. Front. Plant Sci. 6:926. 10.3389/fpls.2015.00926 26583022
Gauthier M., Cano-Lozano V., Zaoujal A., Richard D., (1994). Effects of intracranial injections of scopolamine on olfactory conditioning retrieval in the honeybee. Behav. Brain Res. 63 145–149. 10.1016/0166-4328(94)90085-x
Génissel A., Aupinel P., Bressac C., Tasei J. N., Chevrier C., (2002). Influence of pollen origin on performance of Bombus terrestris microcolonies. Entomol. Exp. Appl. 104 329–336. 10.1046/j.1570-7458.2002.01019.x
Gibson-Corley K. N., Olivier A. K., Meyerholz D. K., (2013). Principles for valid histopathologic scoring in research. Vet. Pathol. 50 1007–1015. 10.1177/0300985813485099 23558974
Gosselin M., Michez D., Vanderplanck M., Roelants D., Glauser G., Rasmont P., (2013). Does Aconitum septentrionale chemically protect floral rewards to the advantage of specialist bumblebees? Ecol. Entomol. 38 400–407. 10.1111/een.12032
Goulson D., Nicholls E., Botias C., Rotheray E. L., (2015). Bee declines driven by combined stress from parasites, pesticides, and lack of flowers. Science 347:1255957. 10.1126/science.1255957 25721506
Haider M., Dorn S., Müler A., (2013). Intra- and interpopulational variation in the ability of a solitary bee species to develop on non-host-pollen: implications for host range expansion. Funct. Ecol. 27 255–263. 10.1111/1365-2435.12021
Hanley M. E., Franco M., Pichon S., Darvill B., Goulson D., (2008). Breeding system, pollinator choice and variation in pollen quality in British herbaceous plants. Funct. Ecol. 22 592–598. 10.1111/j.1365-2435.2008.01415.x
Harrison X. A., (2014). Using observation-level random effects to model overdispersion in count data in ecology and evolution. PeerJ 2:e616. 10.7717/peerj.616 25320683
Hart B. L., (2011). Behavioural defences in animals against pathogens and parasites: parallels with the pillars of medicine in humans. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366 3406–3417. 10.1098/rstb.2011.0092 22042917
Herbert E. W., (1992). “Honey bee nutrition,” in The Hive and the Honeybee, ed. Graham J. M., (Hamilton, IL: Dadant), 197–233.
Hothorn T., Bretz F., Westfall P., (2008). Simultaneous inference in general parametric models. Biom. J. 50 346–363. 10.1002/bimj.200810425 18481363
Human H., Nicolson S. W., Strauss K., Pirk C. W. W., Dietemann V., (2007). Influence of pollen quality on ovarian development in honeybee workers (Apis mellifera scutellata). J. Insect Physiol. 53 649–655. 10.1016/j.jinsphys.2007.04.002 17543984
Humphrey P. T., Gloss A. D., Alexandre N. M., Villalobos M. M., Fremgen M. R., Groen S. C., et al. (2016). Aversion and attraction to harmful plant secondary compounds jointly shape the foraging ecology of a specialist herbivore. Ecol. Evol. 6 3256–3268. 10.1002/ece3.2082 27096082
Hurst V., Stevenson P. C., Wright G. A., (2014). Toxins induce ‘malaise’ behaviour in the honeybee (Apis mellifera). J. Comp. Physiol. A. 200 881–890. 10.1007/s00359-014-0932-0 25149875
Hügel M. F., (1962). Etude de quelques constituants du pollen. Ann. l’Abeille 5 97–133. 10.1051/apido:19620201
Ismail N., Christine S., Robinson G. E., Fahrbach S. E., (2008). Pilocarpine improves recognition of nestmates in young honey bees. Neurosci. Lett. 439 178–181. 10.1016/j.neulet.2008.05.014 18514413
Janashia I., Alaux C., (2016). Specific immune stimulation by endogenous bacteria in honey bees (Hymenoptera: Apidae). J. Econ. Entomol. 109 1474–1477. 10.1093/jee/tow065 27063842
Kempf M., Heil S., Haßlauer I., Schmidt L., von der Ohe K., Theuring C., et al. (2010). Pyrrolizidine alkaloids in pollen and pollen products. Mol. Nutr. Food Res. 54 292–300. 10.1002/mnfr.200900289 20013884
Kešnerová L., Mars R. A. T., Ellegaard K. M., Troilo M., Sauer U., Engel P., (2017). Disentangling metabolic functions of bacteria in the honey bee gut. PLoS Biol. 15:e2003467. 10.1371/journal.pbio.2003467 29232373
Kevan P. G., Ebert T., (2005). Can almond nectar and pollen poison honey bees? Am. Bee J. 145 507–509.
King M. J., (1993). Buzz foraging mechanism in bumble bees. J. Apic. Res. 32 41–49. 10.1080/00218839.1993.11101286
Kitaoka T. K., Nieh J. C., (2009). Bumble bee pollen foraging regulation: role of pollen quality, storage levels, and odor. Behav. Ecol. Sociobiol. 63 501–510. 10.1007/s00265-008-0684-3
Kissen R., Rossiter J. T., Bones A. M., (2009). The “Mustard Oil Bomb”: not so easy to assemble?! localization, expression and distribution of the components of the myrosinase enzyme system. Phytochem. Rev. 8, 69–86. 10.1007/s11101-008-9109-1
Kleijn D., Raemakers I., (2008). A retrospective analysis of pollen host plant use by stable and declining bumble bee species. Ecology 89 1811–1823. 10.1890/07-1275.1
Kolassa J. E., Jankowski S., (2021). MultNonParam: Mutlivariate Nonparametric Methods. R package Version 1.3.5. Available online at: https://cran.r-project.org/package=MultNonParam. (Accessed June 3, 2021).
Kuznetsova A., Brockhoff P. B., Christensen R. H. B., (2017). lmerTest package: tests in linear mixed effects models. J. Stat. Softw. 82 1–26.
Leonhardt S. D., Blüthgen N., (2012). The same, but different: pollen foraging in honeybee and bumblebee colonies. Apidologie 43 449–464. 10.1007/s13592-011-0112-y
Levin M. D., Haydak M. H., (1957). Comparative value of different pollens in the nutrition of Osmia lignaria Say (Hymenoptera: Apoidea). Bee World 38 221–226. 10.1080/0005772x.1957.11095007
London-Shafir I., Shafir S., Eisikowitch D., (2003). Amygdalin in almond nectar and pollen–facts and possible roles. Plant Syst. Evol. 238 87–95. 10.1007/s00606-003-0272-y
Lunau K., (2000). The ecology and evolution of visual pollen signals. Plant Syst. Evol. 222 89–111. 10.1007/978-3-7091-6306-1_5
Lunau K., Piorek V., Krohn O., Pacini E., (2015). Just spines–mechanical defense of malvaceous pollen against collection by corbiculate bees. Apidologie 46 144–149. 10.1007/s13592-014-0310-5
Ma C., Kessler S., Simpson A., Wright G. A., (2016). Novel behavioral assay to investigate gustatory responses of individual, freely-moving bumble bees (Bombus terrestris). J. Vis. Exp. 113:54233.
Manson J. S., Otterstatter M. C., Thomson J. D., (2010). Consumption of a nectar alkaloid reduces pathogen load in bumble bees. Oecologia 162 81–89. 10.1007/s00442-009-1431-9 19711104
Marqués A., Juan A., Ruíz M., Traveset A., Leza M., (2019). Improvement of almond production using Bombus terrestris (Hymenoptera: Apidae) in Mediterranean conditions. J. Appl. Entomol. 143 1132–1142. 10.1111/jen.12690
Mazumder A., Dwivedi A., du Plessis J., (2016). Sinigrin and its therapeutic benefits. Molecules 21:416. 10.3390/molecules21040416 27043505
Mendiburu F., (2020). Agricolae: Statistical Procedures for Agricultural Research. R Package Version 1.3-3. Available online at: http://CRAN.R-project.org/package=agricolae. (Accessed June 6, 2021)
Moerman R., Vanderplanck M., Fournier D., Jacquemart A.-L., Michez D., (2017). Pollen nutrients better explain bumblebee colony development than pollen diversity. Insect Conserv. Divers. 10 171–179. 10.1111/icad.12213
Mommaerts V., Wackers F., Smagghe G., (2013). Assessment of gustatory responses to different sugars in harnessed and free-moving bumblebee workers (Bombus terrestris). Chem. Senses 38 399–407. 10.1093/chemse/bjt014 23599218
Moore B. D., Andrew R. L., Külheim C., Foley W. J., (2014). Explaining intraspecific diversity in plant secondary metabolites in an ecological context. New Phytol. 201 733–750. 10.1111/nph.12526 24117919
Moret Y., Schmid-Hempel P., (2000). Survival for immunity: the price of immune system activation for bumblebee workers. Science 290 1166–1168. 10.1126/science.290.5494.1166 11073456
Müller A., (1996). Convergent evolution of morphogical specializations in Central European bee and honey wasp species as an adaptation to the uptake of pollen from nototribic flowers (Hymenoptera, Apoidea and Masaridae). Biol. J. Linn. Soc. 57 235–252. 10.1006/bijl.1996.0013
Muth F., Francis J. S., Leonard A. S., (2016). Bees use the taste of pollen to determine which flowers to visit. Biol. Lett. 12:20160356. 10.1098/rsbl.2016.0356 27405383
Nayar J. K., Thorsteinson A. J., (1963). Further investigations into the chemical basis of insect-host plant relationships in an oligophagous insect, Plutella maculipennis (Curtis) (Lepidoptera: Plutellidae). Can. J. Zool. 41 923–929. 10.1139/z63-066 33356898
Palmer-Young E. C., Farrell I. W., Adler L. S., Milano N. J., Egan P., Juncker R., et al. (2019). Chemistry of floral rewards: intra- and interspecific variability of nectar and pollen secondary metabolites across taxa. Ecol. Monogr. 89:e01335.
Palmer-Young E. C., Tozkar C. O., Schwarz R. S., Chen Y., Irwin R. E., Adler L. S., et al. (2017). Nectar and pollen phytochemicals stimulate honey bee (Hymenoptera: Apidae) immunity to viral infection. J. Econ. Entomol. 110 1959–1972. 10.1093/jee/tox193 28981688
Paris L., Peghaire E., Moné A., Diogon M., Debroas D., Delbac F., et al. (2020). Honeybee gut microbiota dysbiosis in pesticide/parasite co-exposures is mainly induced by Nosema ceranae. J. Invertebr. Pathol. 172:107348. 10.1016/j.jip.2020.107348 32119953
Parker B. J., Barribeau S. M., Laughton A. M., de Roode J. C., Gerardo N. M., (2011). Non-immunological defense in an evolutionary framework. Trends Ecol. Evol. 26 242–248. 10.1016/j.tree.2011.02.005 21435735
Pernal S., Currie R., (2002). Discrimination and preferences for pollen-based cues by foraging honeybees, Apis mellifera L. Anim. Behav. 63 369–390. 10.1006/anbe.2001.1904
Potts S. G., Imperatriz-Fonseca V., Ngo H., Aizen M., Biesmeijer J., Breeze T., et al. (2016). Safeguarding pollinators and their values to human well-being. Nature 540 220–229. 10.1038/nature20588 27894123
Povey S., Cotter S. C., Simpson S. J., Lee K. P., Wilson K., (2008). Can the protein costs of bacterial resistance be offset by altered feeding behaviour? J. Anim. Ecol. 78 437–446. 10.1111/j.1365-2656.2008.01499.x 19021780
Praz C. J., Müller A., Dorn S., (2008a). Host recognition in a pollen-specialist bee: evidence for a genetic basis. Apidologie 39 547–557. 10.1051/apido:2008034
Praz C. J., Müller A., Dorn S., (2008b). Specialized bees fail to develop on non-host pollen: do plants chemically protect their pollen? Ecology 89 795–804. 10.1890/07-0751.1
Quezada-Euan J. J. G., Lopez-Velasco A., Perez-Balam J., Moo-Valle H., Velazquez-Madrazo A., Paxton R. J., (2011). Body size differs in workers produced across time and is associated with variation in the quantity and composition of larval food in Nannotrigona perilampoides (Hymenoptera. Meliponini). Insectes Soc. 58 31–38. 10.1007/s00040-010-0113-2
R Core Team (2017). R: a Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing.
Rasheed S. A., Harder L. D., (1997). Economic motivation for plant species preferences of pollen-collecting bumble bees. Econ. Entomol. 2 209–219. 10.1046/j.1365-2311.1997.t01-1-00059.x
Rasmont P., Coppée A., Michez D., De Meulemeester T., (2008). An overview of the Bombus terrestris (L. 1758) subspecies (Hymenoptera: Apidae). Ann. Soc. Entomol. Fr. 44 243–250. 10.1080/00379271.2008.10697559
Rasmont P., Regali A., Ings T. C., Lognay G., Baudart E., Marlier M., et al. (2005). Analysis of pollen and nectar of Arbutus unedo as a food source for Bombus terrestris (Hymenoptera: Apidae). J. Econ. Entomol. 98 656–663.
Reilly S., Schachtman R., (2009). Conditioned Taste Aversion: Behavioral and Neural Processes. Oxford: Oxford University Press.
Richards L. A., Dyer L. A., Forister M. L., Smilanich A. M., Dodson C. D., Leonard M. D., et al. (2015). Phytochemical diversity drives plant–insect community diversity. Proc. Natl. Acad. Sci. U.S.A. 112 10973–10978. 10.1073/pnas.1504977112 26283384
Richardson L. L., Adler L. S., Leonard A. S., Andicoechea J., Regan K. H., Anthony W. E., et al. (2015). Secondary metabolites in floral nectar reduce parasite infections in bumblebees. Proc. R. Soc. B 282:20142471. 10.1098/rspb.2014.2471 25694627
Ricketts T. H., Regetz J., Steffan-Dewenter I., Cunningham S. A., Kremen C., Bogdanski A., et al. (2008). Landscape effects on crop pollination services: are there general patterns? Ecol. Lett. 11 499–515. 10.1111/j.1461-0248.2008.01157.x 18294214
Rivest S., Forrest J. R. K., (2020). Defence compounds in pollen: why do they occur and how do they affect the ecology and evolution of bees? New Phytol. 225 1053–1064. 10.1111/nph.16230 31569278
Robertson A. W., Mountjoy C., Faulkner B. E., Roberts M. V., Macnair M. R., (1999). Bumblebee selection of Mimulus guttatus flowers: the effects of pollen quality and reward depletion. Ecology 80 2594–2606. 10.2307/177243
Robinson M. E., (1930). Cyanogenesis in plants. Biol. Rev. 5 126–141. 10.1111/j.1469-185x.1930.tb00896.x
Roger N., Michez D., Wattiez R., Sheridan C., Vanderplanck M., (2017). Diet effects on bumblebee health. J. Insect Physiol. 96 128–133. 10.1016/j.jinsphys.2016.11.002 27836801
Roulston T. H., Cane J. H., (2000). Pollen nutritional content and digestibility for animals. Plant Syst. Evol. 222 187–209. 10.1007/978-3-7091-6306-1_10
Roulston T. H., Cane J. H., Buschmann S. L., (2000). What governs protein content of pollen: pollinator preferences, pollen-pistil interactions, or phylogeny? Ecol. Monogr. 70 617–643. 10.2307/2657188
Ruedenauer F. A., Raubenheimer D., Kessner-Beierlen D., Grund-Muller N., Noack L., Spaethe J., et al. (2020a). Best be(e) on low fat: linking nutrient perception, regulation and fitness. Ecol. Lett. 23 545–554. 10.1111/ele.13454 31943632
Ruedenauer F. A., Spaethe J., Leonhardt S. D., (2015). How to know which food is good for you: bumblebees use taste to discriminate between different concentrations of food differing in nutrient content. J. Exp. Biol. 218 2233–2240. 10.1242/jeb.118554 26202778
Ruedenauer F. A., Spaethe J., Leonhardt S. D., (2016). Hungry for quality—individual bumblebees forage flexibly to collect high-quality pollen. Behav. Ecol. Sociobiol. 70 1209–1217. 10.1007/s00265-016-2129-8
Ruedenauer F. A., Sydow D., Spaethe J., Leonhardt S. D., (2020b). Young bumblebees may rely on both direct pollen cues and early experience when foraging. Proc. R. Soc. B 287:20201615. 10.1098/rspb.2020.1615 32842923
Sáez A., Aizen M. A., Medici S., Viel M., Villalobos E., Negri P., (2020). Bees increase crop yield in an alleged pollinator-independent almond variety. Sci. Rep. 10:3177.
Sarwade A. B., Bhawane G. P., (2013). Anatomical and histological structure of digestive tract of adult Platynotus belli (Coleoptera: Tenebrionidae). Biol. Forum Int. J. 5 47–55.
Sedivy C., Müller A., Dorn S., (2011). Closely related pollen generalist bees differ in their ability to develop on the same pollen diet: evidence for physiological adaptations to digest pollen. Funct. Ecol. 25 718–725. 10.1111/j.1365-2435.2010.01828.x
Shields V. D. C., Mitchell B. K., (1995). Sinigrin as a feeding deterrent in two crucifer-feeding, polyphagous lepidopterous species and the effects of feeding stimulant mixtures on deterrency. Philos. Trans. R. Soc. Lond. B 347 439–446. 10.1098/rstb.1995.0035
Singaravelan N., Ne’eman G., Inbar M., Izhaki I., (2005). Feeding responses of free-flying honeybees to secondary compounds mimicking floral nectars. J. Chem. Ecol. 31 2791–2804. 10.1007/s10886-005-8394-z 16365705
Singer M. S., Mace K. C., Bernays E. A., (2009). Self-medication as adaptative plasticity: increased ingestion of plant toxins by parasitized caterpillars. PLoS One 4:e4796. 10.1371/journal.pone.0004796 19274098
Stegemann T., Kruse L. H., Brütt M., Ober D., (2018). Specific distribution of pyrrolizidine alkaloids in floral parts of comfrey (Symphytum officinale) and its implications for flower ecology. J. Chem. Ecol. 45 128–135. 10.1007/s10886-018-0990-9 30054770
Stevenson P. C., (2020). For antagonists and mutualists: the paradox of insect toxic secondary metabolites in nectar and pollen. Phytochem. Rev. 19 603–614. 10.1007/s11101-019-09642-y
Stevenson P. C., Nicolson S. W., Wright G. A., (2017). Plant secondary metabolites in nectar: impacts on pollinators and ecological functions. Funct. Ecol. 31 65–75. 10.1111/1365-2435.12761
Tasei J. N., Aupinel P., (2008a). Nutritive value of 15 single pollens and pollen mixes tested on larvae produced by bumble bee workers (Bombus terrestris, Hymenoptera: Apidae). Apidologie 39 397–409. 10.1051/apido:2008017
Tasei J. N., Aupinel P., (2008b). Validation of a method using queenless Bombus terrestris micro-colonies for testing the nutritive value of commercial pollen mixes by comparison with queenright colonies. J. Econ. Entomol. 101 1737–1742. 10.1603/0022-0493-101.6.1737 19133450
Thomson J. D., Thomson B. A., (1992). “Pollen presentation and viability schedules in animal-pollinated plants: consequences for reproductive success,” in Ecology and Evolution of Plant Reproduction: New Approaches, ed. Wyatt R., (New York, NY: Chapman & Hall), 1–24.
Tiedeken E. J., Stout J. C., Stevenson P. C., Wright G. A., (2014). Bumblebees are not deterred by ecologically relevant concentrations of nectar toxins. J. Exp. Biol. 217 1620–1625.
Trunz V., Lucchetti M. A., Bénon D., Dorchin A., Desurmont G. A., Kast C., et al. (2020). To bee or not to bee: the ‘raison d’être’ of toxic secondary compounds in the pollen of Boraginaceae. Funct. Ecol. 34 1345–1357. 10.1111/1365-2435.13581
Vanderplanck M., Declèves S., Roger N., Decroo C., Caulier G., Glauser G., et al. (2018). Is non-host pollen suitable for generalist bumblebees? Insect Sci. 25 259–272. 10.1111/1744-7917.12410 27731933
Vanderplanck M., Gilles H., Nonclercq D., Duez P., Gerbaux P., (2020). Asteraceae paradox: chemical and mechanical protection of Taraxacum pollen. Insects 11:304. 10.3390/insects11050304 32422920
Vanderplanck M., Martinet B., Carvalheiro L. G., Rasmont P., Barraud A., Renaudeau C., et al. (2019a). Ensuring access to high-quality resources reduces the impacts of heat stress on bees. Sci. Rep. 9:12596.
Vanderplanck M., Moerman R., Rasmont P., Lognay G., Wathelet B., Wattiez R., et al. (2014). How does pollen chemistry impact development and feeding behaviour of polylectic bees? PLoS One 9:e86209. 10.1371/journal.pone.0086209 24465963
Vanderplanck M., Roger N., Moerman R., Ghisbain G., Gérard M., Popowski D., et al. (2019b). Bumble bee parasite prevalence but not genetic diversity impacted by the invasive plant Impatiens glandulifera. Ecosphere 10:e02804.
Vaudo A. D., Patch H. M., Mortensen D. A., Tooker J. F., Grozinger C. M., (2016a). Macronutrient ratios in pollen shape bumble bee (Bombus impatiens) foraging strategies and floral preferences. Proc. Natl. Acad. Sci. U.S.A. 113 E4035–E4042.
Vaudo A. D., Stabler D., Patch H. M., Tooker J. F., Grozinger C. M., Wright G. A., (2016b). Bumble bees regulate their intake of essential protein and lipid pollen macronutrients. J. Exp. Biol. 219 3962–3970.
Vaudo A. D., Tooker J. F., Grozinger C. M., Patch H. M., (2015). Bee nutrition and floral resource restoration. Curr. Opin. Insect Sci. 10 133–141. 10.1016/j.cois.2015.05.008 29588000
Vaudo A. D., Tooker J. F., Patch H. M., Biddinger D. J., Coccia M., Crone M. K., et al. (2020). Pollen protein:lipid macronutrient ratios may guide broad patterns of bee species floral preferences. Insects 11:132. 10.3390/insects11020132 32085627
Velthuis H. H. W., van Doorn A., (2006). A century of advances in bumblebee domestication and the economic and environmental aspect of its commercialization for pollination. Apidologie 37 421–451. 10.1051/apido:2006019
Weiner C. N., Hilpert A., Werner M., Linsenmair K. E., Bluthgen N., (2010). Pollen amino acids and flower specialisation in solitary bees. Apidologie 41 476–487. 10.1051/apido/2009083
Westerkamp C., Claben-Bockhoff R., (2007). Bilabiate flowers: the ultimate response to bees? Ann. Bot. 100 361–374. 10.1093/aob/mcm123 17652341
Winfree R., Aguilar R., Vasquez D. P., LeBuhn G., Aizen M. A., (2009). A meta-analyis of bees’responses to anthropogenic disturbance. Ecology 90 2068–2076. 10.1890/08-1245.1
Wink M., (1993). “Allelochemical properties or the raison d’être of Alkaloids,” in The Alkaloids, Vol. 43 ed. Cordell J., (New York, NY: Academic Press), 1–118. 10.1016/s0099-9598(08)60134-0
Wright G. A., Baker D. D., Palmer M. J., Stabler D., Mustard J. A., Power E. F., et al. (2013). Caffeine in floral nectar enhances a pollinator’s memory of reward. Science 339 1202–1204. 10.1126/science.1228806 23471406
Wright G. A., Mustard J. A., Simcock N. K., Ross-Taylor A. A., McNicholas L. D., Popescu A., et al. (2010). Parallel reinforcement pathways for conditioned food aversions in the honeybee. Curr. Biol. 20 2234–2240. 10.1016/j.cub.2010.11.040 21129969
