Age; Cancer; Head neck surgery; Laryngeal; Larynx; Otolaryngology; Squamous cell carcinoma; Young; Young Adult; Humans; Male; Female; Adult; Glottis/surgery; Cohort Studies; Laryngeal Neoplasms/epidemiology; Laryngeal Neoplasms/therapy; Laryngeal Neoplasms/pathology; Carcinoma, Squamous Cell/pathology; Larynx/pathology; Carcinoma, Squamous Cell; Glottis; Laryngeal Neoplasms; Otorhinolaryngology; General Medicine
Abstract :
[en] [en] OBJECTIVE: To investigate epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer (LC).
METHODS: PubMed, Scopus and Cochrane Library were searched by three researchers for studies investigating epidemiological, clinical and oncological outcomes of patients with age < 40 years old and LC. The following outcomes were investigated with PRISMA criteria: age; ethnicity; gender; tobacco/alcohol habits; anatomical, pathological, therapeutic and survival features. Authors performed a bias analysis of papers and provided recommendations for future studies.
RESULTS: Seventeen papers published between 1982 and 2021 met our inclusion criteria, accounting for 928 patients with age < 40 years (female/male ratio: 2:5). There were on average 54.2 and 45.8% of smokers and drinkers. The tumor location mainly consisted of glottis (70.1%), supraglottis (27.7%) and subglottis (2.2%). Radiation therapy was the main therapeutic strategy used in young adults with LC. The 2-year overall survival ranged from 50 to 100% and depended on tumor stage, treatment, and cohort features. Four studies reported better overall survival in young compared with old adults, while there were no significant differences in three studies. There was an important heterogeneity between studies regarding the inclusion/exclusion criteria, epidemiological, clinical, pathological and treatment.
CONCLUSION: It was suggested that young patients with LC had lower proportion of smokers and drinkers and better overall survival compared with older but both data of the current literature and heterogeneity between studies limit us to draw definitive conclusions.
Disciplines :
Otolaryngology
Author, co-author :
Lechien, Jérome ; Université de Mons - UMONS > Faculté de Psychologie et des Sciences de l'Education > Service de Métrologie et Sciences du langage
Maniaci, Antonino; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Medical, Surgical Sciences and Advanced Technologies G.F Ingrassia, ENT Section, University of Catania, 95124, Catania, Italy
Hans, Stéphane; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France
Iannella, Giannicola; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forli, Italy ; Department of 'Organi di Senso', University "Sapienza", Viale dell'Università, 33, 00185, Rome, Italy
Fakhry, Nicolas; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France
Mayo-Yáñez, Miguel; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Complex of A Coruña, A Coruña, Spain
Ayad, Tareck; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Otolaryngology-Head and Neck Surgery, University Hospital of Montreal, Montreal, Canada
Mannelli, Giuditta; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgery and Translational Medicine, University of Florence, AOU-Careggi, Florence, Italy
Chiesa-Estomba, Carlos M; Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France ; Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain
Language :
English
Title :
Epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer: a systematic review.
Publication date :
December 2022
Journal title :
European Archives of Oto-Rhino-Laryngology
ISSN :
0937-4477
eISSN :
1434-4726
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
Global Burden of Disease Cancer Collaboration (2019) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study. JAMA Oncol 5:1749–1768 DOI: 10.1001/jamaoncol.2019.2996
Aupérin A (2020) Epidemiology of head and neck cancers: an update. Curr Opin Oncol 32(3):178–186. 10.1097/CCO.0000000000000629 DOI: 10.1097/CCO.0000000000000629
Reizenstein JA, Bergström SN, Holmberg L, Linder A, Ekman S, Blomquist E, Lödén B, Holmqvist M, Hellström K, Nilsson CO, Brattström D, Bergqvist M (2010) Impact of age at diagnosis on prognosis and treatment in laryngeal cancer. Head Neck 32(8):1062–1068. 10.1002/hed.21292 DOI: 10.1002/hed.21292
Nachalon Y, Cohen O, Alkan U, Shvero J, Popovtzer A (2017) Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncol Lett 13(3):1393–1397. 10.3892/ol.2016.5528 DOI: 10.3892/ol.2016.5528
Wang J, Zhao X, Pan X, Zhao L, Zhou J, Ji M (2015) The role of primary surgical treatment in young patients with squamous cell carcinoma of the larynx: a 20-year review of 34 cases. World J Surg Oncol 13:283. 10.1186/s12957-015-0699-y DOI: 10.1186/s12957-015-0699-y
Bradley PJ (2016) Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity? Curr Opin Otolaryngol Head Neck Surg 24(2):140–147 DOI: 10.1097/MOO.0000000000000230
Thompson M, Tiwari A, Fu R, Moe E, Buckley DI (2012) A framework to facilitate the use of systematic reviews and meta-analyses in the design of primary research studies. Rockville (MD): Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK83621/. Accessed 22 Feb 2020
McInnes MDF, Moher D, Thombs BD et al (2018) Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA Statement. JAMA 319(4):388–396. 10.1001/jama.2017.19163 DOI: 10.1001/jama.2017.19163
Burns PB, Rohrich RJ, Chung KC (2011) The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg 128(1):305–310. 10.1097/PRS.0b013e318219c171 DOI: 10.1097/PRS.0b013e318219c171
Viswanathan M, Berkman ND, Dryden DM, Hartling L (2013) Assessing Risk of Bias and Confounding in Observational Studies of Interventions or Exposures: Further Development of the RTI Item Bank. Rockville (MD): Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK154461/. Accessed 20 Oct 2019
Newman RK, Byers RM (1982) Squamous carcinoma of the larynx in patients under the age of 35 years. Otolaryngol Head Neck Surg 90(4):431–433 DOI: 10.1177/019459988209000412
Webber P (1984) Carcinoma of the larynx in a young population (with reference to other head and neck sites). J Laryngol Otol 98(9):901–904. 10.1017/s002221510014767x DOI: 10.1017/s002221510014767x
Mendez PJ, Maves MD, Panje WR (1985) Squamous cell carcinoma of the head and neck in patients under 40 years of age. Arch Otolaryngol 111:762–764 DOI: 10.1001/archotol.1985.00800130094013
Shvero J, Hadar T, Segal K et al (1987) Laryngeal carcinoma in patients 40 years of age and younger. Cancer 60:3092–3095 DOI: 10.1002/1097-0142(19871215)60:12<3092::AID-CNCR2820601239>3.0.CO;2-H
Benninger MS, Roberts JK, Levine HL, Wood BG, Tucker HM (1988) Squamous cell carcinoma of the head and neck in patients 40 years of age and younger. Laryngoscope 98(5):531–534. 10.1288/00005537-198805000-00011 DOI: 10.1288/00005537-198805000-00011
Petrovic Z, Stojcic G, Lcsic S (1996) Laryngeal carcinoma in younger patients. J Laryngol Otol 110(10):934–936 DOI: 10.1017/S002221510013539X
Singh B, Alfonso A, Sabin S, Poluri A, Shaha AR, Sundaram K, Lucente FE (2000) Outcome differences in younger and older patients with laryngeal cancer: a retrospective case-control study. Am J Otolaryngol 21:92–97 DOI: 10.1016/S0196-0709(00)85004-8
Albright JT, Topham AK, Reilly JS (2002) Pediatric head and neck malignancies: US incidence and trends over 2 decades. Arch Otolaryngol Head Neck Surg 128(6):655–659. 10.1001/archotol.128.6.655 DOI: 10.1001/archotol.128.6.655
Rutt AL, Hawkshaw MJ, Sataloff RT (2010) Laryngeal cancer in patients younger than 30 years: a review of 99 cases. Ear Nose Throat J 89:189–192 DOI: 10.1177/014556131008900412
Luna-Ortiz K, Villavicencio-Valencia V, Pasche P, Lavin-Lozano A, Herrera-Gómez A (2011) Laryngeal cancer in patients younger vs older than 40 years old: a matched-paired analysis. Acta Otorrinolaringol Esp 62(2):113–118. 10.1016/j.otorri.2010.09.016 DOI: 10.1016/j.otorri.2010.09.016
Mafi N, Kadivar M, Hosseini N, Ahmadi S, Zare MA (2012) Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pac J Cancer Prev 13:3373–3378 DOI: 10.7314/APJCP.2012.13.7.3373
Bezerra de Souza DL, Jerez Roig J, Bernal MM (2012) Laryngeal cancer survival in Zaragoza (Spain): a population-based study. Clin Transl Oncol 14:221–224 DOI: 10.1007/s12094-012-0787-1
Nachalon Y, Alkan U, Shvero J, Yaniv D, Shkedy Y, Limon D, Popovtzer A (2018) Assessment of laryngeal cancer in patients younger than 40 years. Laryngoscope 128(7):1602–1605. 10.1002/lary.26951 DOI: 10.1002/lary.26951
Silén S, Haapaniemi A, Dickinson A, Rönn K, Mäkitie A (2019) Presentation of second primary cancers in young laryngeal carcinoma patients. Acta Otolaryngol 139(1):85–89. 10.1080/00016489.2018.1527037 DOI: 10.1080/00016489.2018.1527037
Clark RM, Rosen IB, Laperriere NJ (1982) Malignant tumors of the head and neck in a young population. Am J Surg 144(4):459–462. 10.1016/0002-9610(82)90423-8 DOI: 10.1016/0002-9610(82)90423-8
Carniol PJ, Fried MP (1982) Head and neck carcinoma in patients under 40 years of age. Ann Otol Rhinol Laryngol 91(2 Pt 1):152–155. 10.1177/000348948209100206 DOI: 10.1177/000348948209100206
Lund VJ, Howard DJ (1990) Head and neck cancer in the young: a prognostic conundrum? J Laryngol Otol 104:544–548 DOI: 10.1017/S002221510011312X
Toporcov TN, Znaor A, Zhang ZF, Yu GP, Winn DM, Wei Q et al (2015) Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. Int J Epidemiol 44(1):169–185. 10.1093/ije/dyu255 DOI: 10.1093/ije/dyu255
Lechien JR, Sadoughi B, Hans S (2022) Laryngeal cancers in paediatric and young adult patients: epidemiology, biology and treatment. Curr Opin Otolaryngol Head Neck Surg 30(2):145–153. https://doi.org/10.1097/MOO.0000000000000766
Lechien JR, Seminerio I, Descamps G, Mat Q, Mouawad F, Hans S, Julieron M, Dequanter D, Vanderhaegen T, Journe F, Saussez S (2019) Impact of HPV infection on the immune system in oropharyngeal and non-oropharyngeal squamous cell carcinoma: a systematic review. Cells 8(9):1061. 10.3390/cells8091061 DOI: 10.3390/cells8091061
Misono S, Marmor S, Yueh B et al (2014) Treatment and survival in 10,429 patients with localized laryngeal cancer: a population-based analysis. Cancer 120(12):1810–1817 DOI: 10.1002/cncr.28608
Nagam SL, Katta S, Prasad VV (2017) Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients. Mol Carcinog 56(3):895–912. 10.1002/mc.22543 DOI: 10.1002/mc.22543
Bhanu Prasad V, Mallick S, Upadhyay AD, Rath GK (2017) Systematic review and individual patient data analysis of pediatric head and neck squamous cell carcinoma: an analysis of 217 cases. Int J Pediatr Otorhinolaryngol 92:75–81. 10.1016/j.ijporl.2016.11.005 DOI: 10.1016/j.ijporl.2016.11.005
Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349(22):2091–2098. 10.1056/NEJMoa031317 DOI: 10.1056/NEJMoa031317
Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2005) Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol 262(1):21–26. 10.1007/s00405-004-0744-x DOI: 10.1007/s00405-004-0744-x
Lacy PD, Piccirillo JF, Merritt MG, Zequeira MR (2000) Head and neck squamous cell carcinoma: better to be young. Otolaryngol Head Neck Surg 122(2):253–258. 10.1016/S0194-5998(00)70249-X DOI: 10.1016/S0194-5998(00)70249-X
