M. C. Botelho, C. Costa, S. Silva et al., "Effects of titanium dioxide nanoparticles in human gastric epithelial cells in vitro," Biomedicine &Pharmacotherapy, vol. 68, no. 1, pp. 59-64, 2014.
Z. Chen,Y.Wang,T. Ba et al., "Genotoxic evaluationof titanium dioxide nanoparticles in vivo and in vitro," Toxicology Letters, vol. 326, no. 3, pp. 341-349, 2014.
A. Weir, P. Westerhoff, L. Fabricius, K. Hristovski, and N. von Goetz, "Titanium dioxide nanoparticles in food and personal care products," Environmental Science&Technology, vol. 46, no. 4, pp. 2242-2250, 2012.
B. Jovanovic, "Critical reviewof public health regulations of titaniumdioxide, a human food additive," Integrated Environmental Assessment andManagement, vol. 11, no. 1, pp. 10-20, 2015.
C. O. Robichaud, A. E. Uyar, M. R. Darby, L. G. Zucker, and M. R. Wiesner, "Estimates of upper bounds and trends in nano-TiO2 production as a basis for exposure assessment," Environmental Science &Technology, vol. 43, no. 12, pp. 4227-4233, 2009.
L. Rashidi and K. Khosravi-Darani, "The applications of nanotechnology in food industry," Critical Reviews in Food Science and Nutrition, vol. 51, no. 8, pp. 723-730, 2011.
H. Shi, R. Magaye, V. Castranova, and J. Zhao, "Titanium dioxide nanoparticles: a review of current toxicological data," Particle and Fibre Toxicology, 2013.
E. Fabian, R. Landsiedel, L. Ma-Hock, K. Wiench, W. Wohlleben, and B. van Ravenzwaay, "Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats," Archives of Toxicology, vol. 82, no. 3, pp. 151-157, 2008.
J. Ferin, G.Oberdorster, andD. P. Penney, "Pulmonary retention of ultrafine and fine particles in rats," American Journal of Respiratory Cell and Molecular Biology, vol. 6, no. 5, pp. 535-542, 1992.
J. D. Byrne and J. A. Baugh, "The significance of nanoparticles in particle-induced pulmonary fibrosis," McGill Journal of Medicine, vol. 11, no. 1, pp. 43-50, 2008.
M. Valko, D. Leibfritz, J. Moncol, M. T. D. Cronin, M. Mazur, and J. Telser, "Free radicals and antioxidants in normal physiological functions and human disease,"The International Journal of Biochemistry &Cell Biology, vol. 39, no. 1, pp. 44-84, 2007.
W. MacNee, "Oxidative stress and lung inflammation in airways disease," European Journal of Pharmacology, vol. 429, no. 1-3, pp. 195-207, 2001.
K. Donaldson, V. Stone, P. J. A. Borm et al., "Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10)," Free Radical Biology &Medicine, vol. 34, no. 11, pp. 1369-1382, 2003.
G. Ermak and K. J. A. Davies, "Calcium and oxidative stress: from cell signaling to cell death," Molecular Immunology, vol. 38, no. 10, pp. 713-721, 2002.
G. Liang, Y. Pu, L. Yin et al., "Influence of different sizes of titanium dioxide nanoparticles on hepatic and renal functions in rats with correlation to oxidative stress," Journal of Toxicology and Environmental Health, Part A. Current Issues, vol. 72, no. 11-12, pp. 740-745, 2009.
D. Pelclova, V. Zdimal, Z. Fenclova et al., "Markers of oxidative damage of nucleic acids and proteins among workers exposed to TiO2 (nano) particles," Occupational and Environmental Medicine, vol. 73, no. 2, pp. 110-118, 2016.
R. H.Weiss and K. Kim, "Metabolomics in the study of kidney diseases," Nature Reviews Nephrology, vol. 8, no. 1, pp. 22-33, 2012.
S. Grison, G. Fave, M. Maillot et al., "Metabolomics reveals dose effects of low-dose chronic exposure to uranium in rats: identification of candidate biomarkers in urine samples," Metabolomics, vol. 12, no. 154, 2016.
Y.Bo,C. Jin, Y. Liu,W.Yu, andH. Kang, "Metabolomic analysis on the toxicological effects of TiO ," ToxicologyMechanisms and Methods, vol. 24, no. 7, pp. 461-469, 2014.
C. Ratnasekhar, M. Sonane, A. Satish, and M. K. R. Mudiam, "Metabolomics reveals the perturbations in the metabolome of caenorhabditis elegans exposed to titanium dioxide nanoparticles," Nanotoxicology, vol. 9, no. 8, pp. 994-1004, 2015.
X. Valentini, L. Absil, G. Laurent et al., "Toxicity of TiO2 nanoparticles on the NRK52E renal cell line," Molecular &Cellular Toxicology, vol. 13, no. 4, pp. 419-431, 2017.
X. Valentini, P. Deneufbourg, P. Paci et al., "Morphological alterations induced by the exposure to TiO2 nanoparticles in primary cortical neuron cultures and in the brain of rats," Toxicology Reports, vol. 5, pp. 878-889, 2018.
V.Voisin,A.-E. Decleves,V.Hubert et al., "Protection ofWistar-Furth rats against postischaemic acute renal injury: Role for nitric oxide and thromboxane?" Clinical and Experimental Pharmacology and Physiology, vol. 41, no. 11, pp. 911-920, 2014.
G. Laurent, V. Yernaux, D. Nonclercq et al., "Tissue injury and proliferative response induced in rat kidney by cisdiamminedichloroplatinum (II)," Virchows Archiv B: Cell Pathology, vol. 55, no. 1, pp. 129-145, 1988.
D. Nonclercq, G. Toubeau, G. Laurent, P. Maldague, P. M. Tulkens, and J. A.Heuson-Stiennon, "Light and electronmicroscopic characterization of the proliferative response induced by tobramycin in rat kidney cortex," Experimental and Molecular Pathology, vol. 48, no. 3, pp. 335-352, 1988.
D. Nonclercq, G. Toubeau, P. Tulkens, J. A. Heuson-Stiennon, and G. Laurent, "Renal tissue injury and proliferative response after successive treatmentswith anticancer platinum derivatives and tobramycin," Virchows Archiv B Cell Pathology Including Molecular Pathology, vol. 59, no. 1, pp. 143-158, 1990.
D. Nonclercq, D. Reverse, G. Toubeau et al., "In situ demonstration of germinal cell apoptosis during diethylstilbestrolinduced testis regression in adultmale syrian hamsters," Biology of Reproduction, vol. 55, no. 6, pp. 1368-1376, 1996.
T. N. Parac-Vogt, L. Vander Elst, K. Kimpe et al., "Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity," Contrast Media &Molecular Imaging, vol. 1, no. 6, pp. 267-278, 2006.
M. Duquesne, A.-E. Decleves, E. De Prez, J. Nortier, and J. M. Colet, "Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure," Food and Chemical Toxicology, vol. 108, pp. 19-29, 2017.
M. Skocaj, M. Filipic, J. Petkovic, and S. Novak, "Titanium dioxide in our everyday life; Is it safe?" Radiology and Oncology, vol. 45, no. 4, pp. 227-247, 2011.
D. G. Olmedo, D. Tasat, M. B. Guglielmotti, and R. L. Cabrini, "Titanium transport through the blood stream. An experimental study on rats," Journal of Materials Science: Materials in Medicine, vol. 14, no. 12, pp. 1099-1103, 2003.
D. G.Olmedo,D. R. Tasat,M. B. Guglielmotti, andR. L. Cabrini, "Biodistribution of titanium dioxide from biologic compartments," Journal of Materials Science: Materials in Medicine, vol. 19, no. 9, pp. 3049-3056, 2008.
D. G. Olmedo, D. R. Tasat, P. Evelson,M. B. Guglielmotti, and R. L. Cabrini, "Biological response of tissues with macrophagic activity to titanium dioxide," Journal of Biomedical Materials Research Part A, vol. 84, no. 4, pp. 1087-1093, 2008.
J. Chen, X. Dong, J. Zhao, and G. Tang, "In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection," Journal of Applied Toxicology, vol. 29, no. 4, pp. 330-337, 2009.
H. Liu, L. Ma, J. Zhao et al., "Biochemical toxicity of nanoanatase TiO2 particles in mice," Biological Trace Element Research, vol. 129, no. 1-3, pp. 170-180, 2009.
K. Sugibayashi, H. Todo, and E. Kimura, "Safety evaluation of titanium dioxide nanoparticles by their absorption and elimination profiles," The Journal of Toxicological Sciences, vol. 33, pp. 293-298, 2008, Erratum in: Journal of Toxicological Sciences, vol. 33, pp. 668-669.
J.Wang, G. Zhou, C. Chen et al., "Acute toxicity and biodistribution of different sized titanium dioxide particles inmice after oral administration," Toxicology Letters, vol. 168, no. 2, pp. 176-185, 2007.
L. Chen, E. Einbinder, Q. Zhang, J. Hasday, C.W. Balke, and S. M. Scharf, "Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats," American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 7, pp. 915-920, 2005.
V. Pialoux, R. Mounier, A. D. Brown, C. D. Steinback, J. M. Rawling, and M. J. Poulin, "Relationship between oxidative stress andHIF-1mRNA during sustained hypoxia in humans," Free Radical Biology &Medicine, vol. 46, no. 2, pp. 321-326, 2009.
F. H. Epstein, "Oxygen and renal metabolism," Kidney International, vol. 51, no. 2, pp. 381-385, 1997.
B. Trouiller, R. Reliene, A. Westbrook, P. Solaimani, and R. H. Schiestl, "Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo inmice," Cancer Research, vol. 69, no. 22, pp. 8784-8789, 2009.
Z. Shi, Y. Niu, Q. Wang et al., "Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo," Journal of Hazardous Materials, vol. 298, pp. 310-319, 2015.
I.-L. Hsiao, C.-C. Chang, C.-Y. Wu et al., "Indirect effects of TiO2 nanoparticle on neuron-glial cell interactions," Chemico-Biological Interactions, vol. 254, pp. 34-44, 2016.
L. G. Costa, J. M. Garrick, P. J. Roque, and C. Pellacani, "Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more," Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 2986796, 10 pages, 2016.
X. Zhong, X. Yi, R. da Silveira e Sa et al., "CoQ10 deficiency may indicate mitochondrial dysfunction in Cr(VI) toxicity," International Journal of Molecular Sciences, vol. 18, no. 816, pp. 1-20, 2017.
Y. Li, Z. Jiang, D. Xue et al., "Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway," BMC Microbiology, vol. 16, no. 222, 2016.
H.Hu, Q. Guo,C. Wang et al., "Titaniumdioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice," Journal of Applied Toxicology, vol. 35, no. 10, pp. 1122-1132, 2015.
B. Song, Y. Zhang, J. Liu, X. Feng, T. Zhou, and L. Shao, "Unraveling the neurotoxicity of titanium dioxide nanoparticles: Focusing on molecular mechanisms," Beilstein Journal of Nanotechnology, vol. 7, no. 1, pp. 645-654, 2016.
B. Tang, J.Ding, F.Wu, L.Chen, Y. Yang, andF. Song, " 1HNMRbased metabonomics study of the urinary biochemical changes in Kansui treated rat," Journal of Ethnopharmacology, vol. 141, no. 1, pp. 134-142, 2012.
M. Tang, T. Zhang, Y. Xue et al., "Metabonomic studies of biochemical changes in the serum of rats by intratracheally instilled TiO2 nanoparticles," Journal of Nanoscience and Nanotechnology, vol. 11, no. 4, pp. 3065-3074, 2011.
R. Conotte and J.-M. Colet, "A metabonomic evaluation of the monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats," Toxicology and Applied Pharmacology, vol. 276, no. 2, pp. 147-156, 2014.
J. A. Timbrell, V. Seabra, and C. J. Waterfield, "The in vivo and in vitro protective properties of taurine," General Pharmacology: the Vascular System, vol. 26, no. 3, pp. 453-462, 1995
U. Warskulat, F. Zhang, and D. Haussinger, "Taurine is an osmolyte in rat liver macrophages (Kupffer cells)," Journal of Hepatology, vol. 26, no. 6, pp. 1340-1347, 1997.
P. Byung, "Cellular defenses against damage from reactive oxygen species," Physiological Reviews, vol. 74, no. 1, pp. 139-162, 1994.
Y. Zhang, H. Hu, Y. Shi et al., "1H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation," Science of the Total Environment, vol. 589, pp. 212-221, 2017.
A. A. Tolun, H. Zhang, D. Ii'yasova et al., "Allantoin in Human Urine Quantified by UPLC-MS/MS," Analytical Biochemistry, vol. 402, pp. 191-193, 2010.
M. Neerathilingam, D. E. Volk, S. Sarkar et al., "1H NMR-based metabonomic investigation of tributyl phosphate exposure in rats," Toxicology Letters, vol. 199, no. 1, pp. 10-16, 2010.
Q. Bu, G. Yan, P. Deng et al., "NMR-basedmetabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration," Nanotechnology, vol. 21, no. 12, Article ID 125105, 2010.
