Optical Fiber Gratings Immunoassays

[en] Optical fibers are of growing interest for biosensing, especially for point-of-care and biomedical assays. Their intrinsic properties bestow them sought-after assets for the detection of low concentrations of analytes. Tilted fiber Bragg gratings (TFBGs) photo-inscribed in the core of telecommunication-grade optical fibers are known to be highly-sensitive refractometers. In this work, we present different strategies to use them for label-free immunoassays. Bare, gold-sputtered, gold-electroless-plated (ELP) and hybrid configurations are biofunctionalized with antibodies, aiming at the detection of cancer biomarkers. We discuss the relative performances of the tested configurations and show that each leads to singular key features, which therefore drives their selection as a function of the target application. The most sensitive configuration presents a limit of detection of 10-12 g/mL in laboratory settings and was successfully used ex vivo in freshly resected lung tissues.

Disciplines :

Biochemistry, biophysics & molecular biology
Physics

Author, co-author :

Loyez, Médéric ; Université de Mons > Faculté des Sciences > Protéomie et Microbiologie

Lobry, Maxime

Wattiez, Ruddy ; Université de Mons > Faculté des Sciences > Service de Protéomie et Microbiologie

Caucheteur, Christophe ; Université de Mons > Faculté Polytechnique > Electromagnétisme et Télécommunications

Language :

English

Title :

Optical Fiber Gratings Immunoassays

Publication date :

07 June 2019

Journal title :

Sensors

ISSN :

1424-8220

eISSN :

1424-3210

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Volume :

Issue :

Pages :

2595

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S828 - Protéomie et Microbiologie
F108 - Electromagnétisme et Télécommunications

Research institute :

R100 - Institut des Biosciences

Available on ORBi UMONS :

since 07 June 2019

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