Influence of risk factors for male infertility on sperm protein composition

[en] Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summarise the main results obtained in the different studies and provide a compiled list of deregulated proteins in relation to each risk factor. Gene ontology analysis of these deregulated proteins shows that oxidative stress and immune and inflammatory responses are common mechanisms involved in sperm alterations encountered in relation to the risk factors.

Research center :

UMHAP - Centre de Recherche UMONS-Ambroise Paré

Disciplines :

Reproductive medicine (gynecology, andrology, obstetrics)
Biochemistry, biophysics & molecular biology

Author, co-author :

Bisconti, Marie ; Université de Mons > Faculté des Sciences > Service de Biologie cellulaire

Simon, Jean-François

Grassi, Sarah

Leroy, Baptiste ; Université de Mons > Faculté des Sciences > Service de Protéomie et Microbiologie

Martinet, Baptiste ; Université de Mons > Faculté des Sciences > Service de Zoologie

Arcolia, Vanessa

Isachenko, Vladimir

Hennebert, Elise ; Université de Mons > Faculté des Sciences > Service de Biologie cellulaire

Language :

English

Title :

Influence of risk factors for male infertility on sperm protein composition

Publication date :

06 December 2021

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S815 - Biologie cellulaire

Research institute :

R100 - Institut des Biosciences
R550 - Institut des Sciences et Technologies de la Santé

Available on ORBi UMONS :

since 11 January 2022

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