Evidences for the Formation of Bisbenzamidines-heme Complexes in Cell-free Systems

[en] Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of ß-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme-drug, is tentatively proposed. IR spectra and colorimetry data indicated that bisbenzamidines readily interact with heme in cell-free systems at pH 5.0 and 7.0.

Disciplines :

Chemistry

Author, co-author :

Mayence, A.

Vanden Eynde, Jean-Jacques

Huang, T.L.

Language :

English

Title :

Evidences for the Formation of Bisbenzamidines-heme Complexes in Cell-free Systems

Publication date :

01 August 2004

Journal title :

Bioorganic and Medicinal Chemistry Letters

ISSN :

0960-894X

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

Pages :

1625 -1628

Peer reviewed :

Peer Reviewed verified by ORBi

Research unit :

S836 - Synthèse et spectrométrie de masse organiques

Available on ORBi UMONS :

since 10 June 2010

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