[en] For over 60 years, selenium (Se) has been known as an essential microelement to many biological functions, including cardiovascular homeostasis. This review presents a compilation of studies conducted in the past 20 years related to chronic Chagas disease cardiomyopathy (CCC), caused by Trypanosoma cruzi infection, a neglected disease that represents a global burden, especially in Latin America. Experimental and clinical data indicate that Se may be used as a complementary therapy to prevent heart failure and improve heart function. Starting from the main questions "Is Se deficiency related to heart inflammation and arrhythmogenesis in CCC?" and "Could Se be recommended as a therapeutic strategy for CCC?", we show evidence implicating the complex and multidetermined CCC physiopathology, discussing its possible interplays with the multifunctional cytokine TGF-β as regulators of immune response and fibrosis. We present two new proposals to face this global public health challenge in vulnerable populations affected by this parasitic disease: fibrosis modulation mediated by TGF-β pathways and the possible use of selenoproteins as antioxidants regulating the increased reactive oxygen stress present in CCC inflammatory environments. We assess the opportunity to consider the beneficial effects of Se in preventing heart failure as a concept to be applied for CCC patients.
Disciplines :
Immunologie & maladie infectieuse
Auteur, co-auteur :
Araujo-Jorge, Tania C ; Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute (LITEB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Cardoso Fontes, Sala 64, Rio de Janeiro 21040-360, Brazil
Rivera, Maria Teresa; École de Santé Publique, Campus Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Bruxelles, Belgium
Vanderpas, Jean ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service de Chimie thérapeutique et Pharmacognosie ; École de Santé Publique, Campus Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070 Bruxelles, Belgium
Garzoni, Luciana R; Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute (LITEB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Cardoso Fontes, Sala 64, Rio de Janeiro 21040-360, Brazil
Carvalho, Anna Cristina C ; Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute (LITEB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Cardoso Fontes, Sala 64, Rio de Janeiro 21040-360, Brazil
Waghabi, Mariana C; Laboratory of Functional Genomic and Bioinformatics, Oswaldo Cruz Institute (LGFB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Leonidas Deane, Rio de Janeiro 21040-360, Brazil
Holanda, Marcelo T ; Laboratory of Clinical Research in Chagas Disease, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Mediano, Mauro F F; Laboratory of Clinical Research in Chagas Disease, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Hasslocher-Moreno, Alejandro M ; Laboratory of Clinical Research in Chagas Disease, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Bonecini-Almeida, Maria da Gloria; Laboratory of Immunology and Immunogenetics, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Saraiva, Roberto M ; Laboratory of Clinical Research in Chagas Disease, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Rio de Janeiro 21040-360, Brazil
Ferreira, Roberto R; Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute (LITEB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Cardoso Fontes, Sala 64, Rio de Janeiro 21040-360, Brazil ; Laboratory of Functional Genomic and Bioinformatics, Oswaldo Cruz Institute (LGFB-IOC/Fiocruz), Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Manguinhos, Pavilhão Leonidas Deane, Rio de Janeiro 21040-360, Brazil
Langue du document :
Anglais
Titre :
Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease.
R550 - Institut des Sciences et Technologies de la Santé
Organisme subsidiant :
Ministry of Health National Council for Scientific and Technological Development Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Oswaldo Cruz Foundation
Subventionnement (détails) :
Funding: This research was funded by the Department of the Industrial Complex and Innovation in Health at the Brazilian Health Ministry (IOC Fiotec IOC-001-LIV-11-2-1; 25380.001603/2017-89), the governmental agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 309545/2014-5; 313011/2018-4, 159947/2018-9), Fundação de Amparo à Pesquisa no Rio de Janeiro Carlos Chagas Filho (FAPERJ E-26/010.001855/2014; E26/201.838/2017) and the institutional support from Oswaldo Cruz Institute (IOC/Fiocru).This research was funded by the Department of the Industrial Complex and Innovation in Health at the Brazilian Health Ministry (IOC Fiotec IOC-001-LIV-11-2-1; 25380.001603/2017-89), the governmental agencies Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq 309545/2014-5; 313011/2018-4, 159947/2018-9), Funda??o de Amparo ? Pesquisa no Rio de Janeiro Carlos Chagas Filho (FAPERJ E-26/010.001855/2014; E26/201.838/2017) and the institutional support from Oswaldo Cruz Institute (IOC/Fiocru).
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