exhaled breath analysis; gas sensors; lung cancer (LC) diagnosis; metal oxides; Exhaled breath analysis; Gas-sensing materials; Gas-sensors; Low-costs; Lung Cancer; Lung cancer diagnosis; Metal oxide semiconductor; Metal-oxide; Metal-oxides gas sensors; Semiconductor gas; Electronic, Optical and Magnetic Materials; Ceramics and Composites
Abstract :
[en] The urgency of early lung cancer (LC) diagnosis and treatment has been more and more significant. Exhaled breath analysis using gas sensors is a promising way to find out if someone has LC due to its low-cost, non-invasive, and real-time monitoring compared with traditional invasive diagnostic techniques. Among sensor-based gas detection techniques, metal oxide semiconductor’s gas sensors are one of the most important types. This review presents the-state-of-art in metal oxide gas sensors for the diagnosis of early LC. First, the exhaled breath biomarkers are described with emphasis on the concentration of abnormal volatile organic compounds (VOCs) caused by the metabolic process of LC cells. Then, the research status of metal oxide gas sensors in LC diagnosis is summarized. The sensing performance and enhancement strategy of biomarkers provided by metal oxide semiconductor materials are reviewed. Another effective way to improve VOC detection performance is to build a gas sensor array. At the same time, various gas sensors combined with self-powered techniques are mentioned to display a broad development prospect in breath diagnosis. Finally, metal oxide gas sensor-based LC diagnosis is prospected.
Disciplines :
Materials science & engineering
Author, co-author :
He, Xiaoxi; School of Mechanical Engineering, Yangzhou University, Yangzhou, China
Chai, Hongfeng; School of Mechanical Engineering, Yangzhou University, Yangzhou, China
Luo, Yifan; School of Mechanical Engineering, Yangzhou University, Yangzhou, China ; Service de Science des Matériaux, Faculté Polytechnique, Université de Mons, Mons, Belgium
Min, Lingfeng; Department of Respiratory and Critical Care Medicine, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, China
Debliquy, Marc ; Université de Mons - UMONS > Faculté Polytechnique > Service de Science des Matériaux
Zhang, Chao; School of Mechanical Engineering, Yangzhou University, Yangzhou, China
Language :
English
Title :
Metal oxide semiconductor gas sensing materials for early lung cancer diagnosis
Publication date :
February 2023
Journal title :
Journal of Advanced Ceramics
ISSN :
2226-4108
eISSN :
2227-8508
Publisher :
Tsinghua University Press
Volume :
12
Issue :
2
Pages :
207 - 227
Peer reviewed :
Peer Reviewed verified by ORBi
Research unit :
F502 - Science des Matériaux
Research institute :
R400 - Institut de Recherche en Science et Ingénierie des Matériaux
Funding text :
This work is supported by the Outstanding Youth Foundation of Jiangsu Province of China under Grant No. BK20211548, the National Natural Science Foundation of China under Grant No. 51872254, the Yangzhou City– Yangzhou University Cooperation Foundation under Grant No. YZ2021153, and the Walloon Region of Belgium through the Interreg V France–Wallonie– Vlaanderen program under PATHACOV project (Grant No. 1.1.297).
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