Incidence and clinical and microbiological features of invasive and probable invasive streptococcal group A infections in children and adults in the Brussels-Capital Region, 2005-2020.
Chickenpox; Emm type; Epidemiology; Group A Streptococcus; Incidence; Invasive infection; Streptococcus pyogenes; Child; Humans; Adult; Retrospective Studies; Streptococcal Infections/epidemiology; Streptococcal Infections/microbiology; Streptococcal Infections; Microbiology (medical); Infectious Diseases; General Medicine
Abstract :
[en] Assess the incidence, risk factors, clinical and microbiological features, and outcome of both probable invasive and invasive group A Streptococcus (GAS) infections in children and adults in the BrusselsCapital Region between 2005 and 2020. A retrospective, multicentric study was performed in three university hospitals in Brussels. Patients were identified through the centralized laboratory information system. Epidemiological and clinical data were collected from patients' hospital records. A total of 467 cases were identified. Incidence has increased from 2.1 to 10.9/100,000 inhabitants between 2009 and 2019 in non-homeless adults while it was above 100/100,000 on homeless in years with available denominators. Most of GAS were isolated from blood (43.6%), and the most common clinical presentation was skin and soft tissue infections (42.8%). A third of all the patients needed surgery, a quarter was admitted to the intensive care unit, and 10% of the adult patients died. Wounds and chickenpox disease were the main risk factors for children. Tobacco, alcohol abuse, wounds or chronic skin lesion, being homeless, and diabetes were identified as major predisposing factors for adults. The most common emm clusters were D4, E4, and AC3; 64% of the isolates were theoretically covered by the 30-valent M-protein vaccine. The burden of invasive and probable invasive GAS infections is on the rise in the studied adult population. We identified potential interventions that could contribute to decrease this burden: appropriate care of wounds, specifically among homeless and patients with risk factors such as diabetes and systematic chickenpox vaccination for children.
Disciplines :
Immunology & infectious disease
Author, co-author :
Zangarini, Lisa; Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), 322, Rue Haute, 1000, Brussels, Belgium ; Department of Life Science and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-Sur-Alzette, Luxembourg
Martiny, Delphine ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service du Doyen de la Faculté de Médecine et Pharmacie ; Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), 322, Rue Haute, 1000, Brussels, Belgium
Miendje Deyi, Véronique Yvette; Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), 322, Rue Haute, 1000, Brussels, Belgium
Hites, Maya; Clinic of Infectious Diseases, Hôpital Universitaire de Bruxelles Erasme, Brussels, Belgium
Maillart, Evelyne; Department of Infectious Diseases, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels, Belgium
Hainaut, Marc; Pediatrics department, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), 322, Rue Haute, 1000, Brussels, Belgium
Delforge, Marc; Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), 322, Rue Haute, 1000, Brussels, Belgium
Botteaux, Anne; Laboratory of Molecular Bacteriology, Université Libre de Bruxelles (ULB), Brussels, Belgium
Hallin, Marie; Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), 322, Rue Haute, 1000, Brussels, Belgium
Smeesters, Pierre; Laboratory of Molecular Bacteriology, Université Libre de Bruxelles (ULB), Brussels, Belgium
Dauby, Nicolas ; Department of Infectious Diseases, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles (ULB), 322, Rue Haute, 1000, Brussels, Belgium. nicolas.dauby@stpierre-bru.be ; Institute for Medical Immunology, ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium. nicolas.dauby@stpierre-bru.be ; School of Public Health, Université Libre de Bruxelles (ULB), Brussels, Belgium. nicolas.dauby@stpierre-bru.be
Incidence and clinical and microbiological features of invasive and probable invasive streptococcal group A infections in children and adults in the Brussels-Capital Region, 2005-2020.
Publication date :
May 2023
Journal title :
European Journal of Clinical Microbiology and Infectious Diseases
ISSN :
0934-9723
eISSN :
1435-4373
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
Fonds De La Recherche Scientifique - FNRS Koning Boudewijnstichting
Funding text :
This work was supported by F.R.S.-FNRS research grants (PDR T.0255.16 and CDR J.0019.17) and the Fund Iris-Research (managed by the King Baudouin Foundation, grant 2019-J1820690-212134). N. D. is a post-doctorate clinical master specialist of the F.R.S.-FNRS.
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