head and neck cancer; metformin; prevention; systematic review; treatment; Medicine (all); General Medicine
Abstract :
[en] [en] BACKGROUND: Head and neck cancer (HNC) is a complex affection. Nowadays, conventional treatments are associated with many side effects, reducing the patient's quality of life. Recent studies suggest that metformin, a first-line treatment for diabetes, could decrease cancer incidence and improve cancer-related survival rates.
METHODS: This systematic review summarizes important data from studies evaluating metformin's contribution to preventing and treating HNC.
RESULTS: The results suggest a protective effect of metformin in HNC. However, no consensus has been found on its therapeutic effects. Metformin seems to confer an improved cancer-related survival rate in a diabetic population, but compared to a non-diabetic population, the review could not identify any advantages. Nevertheless, no studies presented a negative impact.
CONCLUSION: In conclusion, the results of this systematic review suggest that HNC patients may benefit from metformin. Indeed, it would reduce the HNC incidence. However, more studies are required to evaluate the effect on cancer-related survival rates.
Disciplines :
Oncology
Author, co-author :
Bouland, Cyril ; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Vanden Eynden, Xavier; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Lalmand, Martin; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Buset, Thibaut; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Yanni, Antoine; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Javadian, Rokneddine; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Rodriguez, Alexandra; Department of Otorhinolaryngology-Head and Neck Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Loeb, Isabelle; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Lechien, Jérôme R ; Department of Otorhinolaryngology-Head and Neck Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium ; Laboratory of Human Anatomy and Experimental Oncology, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium
Journe, Fabrice ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service d'Anatomie humaine et Oncologie expérimentale ; Laboratory of Oncology and Experimental Surgery, Jules Bordet Institute, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium
SAUSSEZ, Sven ; Université de Mons - UMONS > Faculté de Médecine et de Pharmac > Service d'Anatomie humaine et Oncologie expérimentale ; Department of Otorhinolaryngology-Head and Neck Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Dequanter, Didier ; Department of Stomatology-Maxillofacial Surgery, CHU-Saint-Pierre, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
Language :
English
Title :
Preventive and Therapeutic Effect of Metformin in Head and Neck Cancer: A Concise Review.
Publication date :
25 September 2023
Journal title :
Journal of Clinical Medicine
eISSN :
2077-0383
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Jemal A. Siegel R. Xu J. Ward E. Cancer statistics, 2010 CA Cancer J. Clin. 2010 60 277 300 10.3322/caac.20073 20610543
Rêgo D.F. Pavan L.M.C. Elias S.T. Canto G.D.L. Guerra E.N.S. Effects of metformin on head and neck cancer: A systematic review Oral Oncol. 2015 51 416 422 10.1016/j.oraloncology.2015.01.007 25636350
Yen Y.-C. Lin C. Lin S.-W. Lin Y.-S. Weng S.-F. Effect of metformin on the incidence of head and neck cancer in diabetics Head Neck 2015 37 1268 1273 10.1002/hed.23743 24801563
Alcusky M. Keith S.W. Karagiannis T. Rabinowitz C. Louis D.Z. Maio V. Metformin exposure and survival in head and neck cancer: A large population-based cohort study J. Clin. Pharm. Ther. 2019 44 588 594 10.1111/jcpt.12820 31293011
Lechien J.R. Seminerio I. Descamps G. Mat Q. Mouawad F. Hans S. Julieron M. Dequanter D. Vanderhaegen T. Journe F. et al. Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review Cells 2019 8 1061 10.3390/cells8091061
Wissinger E. Griebsch I. Lungershausen J. Foster T. Pashos C.L. The Economic Burden of Head and Neck Cancer: A Systematic Literature Review PharmacoEconomics 2014 32 865 882 10.1007/s40273-014-0169-3
Yanni A. Buset T. Bouland C. Loeb I. Lechien J.R. Rodriguez A. Journe F. Saussez S. Dequanter D. Neutrophil-to-lymphocyte ratio as a prognostic marker for head and neck cancer with lung metastasis: A retrospective study Eur. Arch. Otorhinolaryngol. 2022 279 4103 4111 10.1007/s00405-022-07274-1
Wang X. Wang H. Zhang T. Cai L. Dai E. He J. Diabetes and its Potential Impact on Head and Neck Oncogenesis J. Cancer 2020 11 583 591 10.7150/jca.35607
Yamamoto M. Inohara H. Nakagawa T. Targeting metabolic pathways for head and neck cancers therapeutics Cancer Metastasis Rev. 2017 36 503 514 10.1007/s10555-017-9691-z
Curry J.M. Johnson J. Mollaee M. Tassone P. Amin D. Knops A. Whitaker-Menezes D. Mahoney M.G. South A. Rodeck U. et al. Metformin Clinical Trial in HPV+ and HPV− Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate Front. Oncol. 2018 8 436 10.3389/fonc.2018.00436
Wan G. Sun X. Li F. Wang X. Li C. Li H. Yu X. Cao F. Survival Benefit of Metformin Adjuvant Treatment for Pancreatic Cancer Patients: A Systematic Review and Meta-Analysis Cell. Physiol. Biochem. 2018 49 837 847 10.1159/000493214 30184547
Schulte L. Scheiner B. Voigtländer T. Koch S. Schweitzer N. Marhenke S. Ivanyi P. Manns M.P. Rodt T. Hinrichs J.B. et al. Treatment with metformin is associated with a prolonged survival in patients with hepatocellular carcinoma Liver Int. 2019 39 714 726 10.1111/liv.14048 30663219
Ng C.W. Jiang A.A. Toh E.M.S. Ng C.H. Ong Z.H. Peng S. Tham H.Y. Sundar R. Chong C.S. Khoo C.M. Metformin and colorectal cancer: A systematic review, meta-analysis and meta-regression Int. J. Color. Dis. 2020 35 1501 1512 10.1007/s00384-020-03676-x 32592092
Tsou Y.-A. Chang W.-D. Lu J.-J. Wu T.-F. Chen H.-L. Chen C.-M. Tsai M.H. The effect of metformin use on hypopharyngeal squamous cell carcinoma in diabetes mellitus patients BMC Cancer 2019 19 862 10.1186/s12885-019-6083-5
Schardt C. Adams M.B. Owens T. Keitz S. Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions BMC Med. Inform. Decis. Mak. 2007 7 16 10.1186/1472-6947-7-16
Becker C. Jick S.S. Meier C.R. Bodmer M. Metformin and the risk of head and neck cancer: A case-control analysis Diabetes Obes. Metab. 2014 16 1148 1154 10.1111/dom.12351
Tseng C.-H. Metformin may reduce oral cancer risk in patients with type 2 diabetes Oncotarget 2016 7 2000 2008 10.18632/oncotarget.6626
Tseng C.-H. Metformin and risk of developing nasopharyngeal cancer in patients with type 2 diabetes mellitus Metabolism 2018 85 223 226 10.1016/j.metabol.2018.04.009
Sandulache V.C. Hamblin J.S. Skinner H.D. Kubik M.W. Myers J.N. Zevallos J.P. Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma Head Neck 2014 36 1039 1043 10.1002/hed.23409
Spratt D.E. Beadle B.M. Zumsteg Z.S. Rivera A. Skinner H.D. Osborne J.R. Garden A.S. Lee N.Y. The Influence of Diabetes Mellitus and Metformin on Distant Metastases in Oropharyngeal Cancer: A Multicenter Study Int. J. Radiat. Oncol. 2015 94 523 531 10.1016/j.ijrobp.2015.11.007
Gulati S. Desai J. Palackdharry S.M. Morris J.C. Zhu Z. Jandarov R. Riaz M.K. Takiar V. Mierzwa M. Gutkind J.S. et al. Phase 1 Dose-Finding Study of Metformin in Combination with Concurrent Cis-platin and Radiotherapy in Patients with Locally Advanced Head and Neck Squamous Cell Cancer Cancer 2020 126 354 362 10.1002/cncr.32539 31626727
Stokes W.A. Eguchi M. Amini A. Hararah M.K. Ding D. McDermott J.D. Bradley C.J. Karam S.D. Survival impact and toxicity of metformin in head and neck cancer: An analysis of the SEER-Medicare dataset Oral Oncol. 2018 84 12 19 10.1016/j.oraloncology.2018.06.022 30115470
Chang P.-H. Yeh K.-Y. Wang C.-H. Chen E.Y.-C. Yang S.-W. Chou W.-C. Hsieh J.C.-H. Impact of metformin on patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy Head Neck 2017 39 1573 1577 10.1002/hed.24793
Quimby A.E. Lebo N.L. Griffiths R. Hall S. Dimitroulakos J. Johnson-Obaseki S. Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study J. Otolaryngol. Head Neck Surg. 2018 47 74 10.1186/s40463-018-0322-7
Lee D.J. McMullen C.P. Foreman A. Huang S.H. Lu L. Xu W. de Almeida J.R. Liu G. Bratman S.V. Goldstein D.P. Impact of metformin on disease control and survival in patients with head and neck cancer: A retrospective cohort study J. Otolaryngol. Head Neck Surg. 2019 48 34 10.1186/s40463-019-0348-5
Kwon M. Roh J.-L. Song J. Lee S.-W. Kim S.-B. Choi S.-H. Nam S.Y. Effect of Metformin on Progression of Head and Neck Cancers, Occurrence of Second Primary Cancers, and Cause-Specific Survival Oncologist 2015 20 546 553 10.1634/theoncologist.2014-0426
Ogunsakin A. Infield J. Zuber J. Solomon S.S. Metformin Associated with Improved Outcomes in Diabetic Patients with Laryngeal and Oropharyngeal Carcinoma Am. J. Med. Sci. 2018 356 574 575 10.1016/j.amjms.2018.09.002
Mallik R. Chowdhury T.A. Metformin in cancer Diabetes Res. Clin. Pract. 2018 143 409 419 10.1016/j.diabres.2018.05.023 29807101
Lerner M.Z. Mor N. Paek H. Blitzer A. Strome M. Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients Ann. Otol. Rhinol. Laryngol. 2017 126 340 343 10.1177/0003489416688478
Kuo S.Z. Honda C.O. Li W.T. Honda T.K. Kim E. Altuna X. Abhold E. Wang-Rodriguez J. Ongkeko W.M. Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma Int. J. Mol. Sci. 2019 20 193 10.3390/ijms20010193
Yanni A. Dequanter D. Lechien J.R. Loeb I. Rodriguez A. Javadian R. Van Gossum M. Malnutrition in head and neck cancer patients: Impacts and indications of a prophy-lactic percutaneous endoscopic gastrostomy Eur. Ann. Otorhinolaryngol. Head Neck Dis. 2019 136 S27 S33 10.1016/j.anorl.2019.01.001 30846293
ClinicalTrials Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions—Full Text View Available online: https://clinicaltrials.gov/ct2/show/NCT03684707 (accessed on 27 April 2023)
ClinicalTrials Metformin Hydrochloride in Preventing Oral Cancer in Patients with an Oral Premalignant Lesion—Full Text View Available online: https://clinicaltrials.gov/ct2/show/NCT02581137 (accessed on 27 April 2023)
ClinicalTrials Metformin for the Prevention of Oral Cancer in Patients with Oral Leukoplakia or Erythroplakia—Full Text View Available online: https://clinicaltrials.gov/ct2/show/NCT05237960 (accessed on 27 April 2023)
ClinicalTrials Metformin Hydrochloride and Doxycycline in Treating Patients with Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery—Full Text View Available online: https://clinicaltrials.gov/ct2/show/NCT03076281 (accessed on 27 April 2023)
ClinicalTrials Durvalumab With or Without Metformin in Treating Participants with Head and Neck Squamous Cell Carcinoma—Full Text View Available online: https://clinicaltrials.gov/ct2/show/NCT03618654 (accessed on 27 April 2023)
