Specificity of Light-Induced Covalent Adduct Formation between RuII Oligonucleotide Conjugates and Target Sequences for Gene Silencing Applications

Marcelis, Lionel; Surin, Mathieu; Lartia, Rémy; Moucheron, Cécile; Defrancq, Eric; Kirsch-De Mesmaeker, Andrée

doi:10.1002/ejic.201402189

Article (Scientific journals)

Specificity of Light-Induced Covalent Adduct Formation between RuII Oligonucleotide Conjugates and Target Sequences for Gene Silencing Applications

Marcelis, Lionel; Surin, Mathieu; Lartia, Rémy et al.

2014 • In European Journal of Inorganic Chemistry, 2014 (19), p. 3016-3022

Peer Reviewed verified by ORBi

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https://hdl.handle.net/20.500.12907/37033

DOI
10.1002/ejic.201402189

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Abstract :

[en] Under irradiation, Ru-TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes tethered to oligonucleotides (Ru-ODN) hybridized to their complementary target sequences produce irreversible adducts with guanine (G) bases. The interesting feature is that the G bases that react in the double strand (DS) topology belong exclusively to the complementary strand; thus, no G base of the Ru-ODN strand participates in the production of these adducts. This highly specific photoreaction in the DS topology is demonstrated by gel electrophoresis analyses of different duplex sequences in which the positions of the G bases are varied. Atomistic molecular modelling simulations indicate that this specificity is due to important steric constraints for the intrastrand adduct formation in the duplex. Luminescence lifetime measurements furnish more detailed information on these different duplex systems.

Disciplines :

Chemistry

Author, co-author :

Marcelis, Lionel

Surin, Mathieu ; Université de Mons > Faculté des Sciences > Service de Chimie des matériaux nouveaux

Lartia, Rémy

Moucheron, Cécile

Defrancq, Eric

Kirsch-De Mesmaeker, Andrée

Language :

English

Title :

Specificity of Light-Induced Covalent Adduct Formation between RuII Oligonucleotide Conjugates and Target Sequences for Gene Silencing Applications

Publication date :

07 December 2014

Journal title :

European Journal of Inorganic Chemistry

ISSN :

1434-1948

eISSN :

1099-0682

Publisher :

John Wiley & Sons, United Kingdom

Volume :

2014

Issue :

Pages :

3016-3022

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi UMONS :

since 07 December 2016

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Bibliography

M. R. Gill, J. A. Thomas, Chem. Soc. Rev. 2012, 41, 3179-3192.
A. W. McKinley, P. Lincoln, E. M. Tuite, Coord. Chem. Rev. 2011, 255, 2676-2692.
A. C. Komor, J. K. Barton, Chem. Commun. 2013, 49, 3617-3630.
U. Schatzschneider, J. Niesel, I. Ott, R. Gust, H. Alborzinia, S. Wölfl, ChemMedChem 2008, 3, 1104-1109.
U. Schatzschneider, Eur. J. Inorg. Chem. 2010, 1451-1467.
A. E. Friedman, J. C. Chambron, J. P. Sauvage, N. J. Turro, J. K. Barton, J. Am. Chem. Soc. 1990, 112, 4960-4962.
J. Andersson, L. H. Fornander, M. Abrahamsson, E. Tuite, P. Nordell, P. Lincoln, Inorg. Chem. 2013, 52, 1151-1159.
H. Niyazi, J. P. Hall, K. O'Sullivan, G. Winter, T. Sorensen, J. M. Kelly, C. J. Cardin, Nat. Chem. 2012, 4, 621-628.
E. J. C. Olson, D. Hu, A. Hörmann, A. M. Jonkman, M. R. Arkin, E.-D. A. Stemp, J. K. Barton, P. F. Barbara, J. Am. Chem. Soc. 1997, 119, 11458-11467.
J. Olofsson, B. Önfelt, P. Lincoln, J. Phys. Chem. A 2004, 108, 4391-4398.
F. R. Svensson, M. Abrahamsson, N. Stromberg, A. G. Ewing, P. Lincoln, J. Phys. Chem. Lett. 2011, 2, 397-401.
H. Y. Mei, J. K. Barton, Proc. Natl. Acad. Sci. USA 1988, 85, 1339-1343.
A. Ruggi, F. W. B. van Leeuwen, A. H. Velders, Coord. Chem. Rev. 2011, 255, 2542-2554.
S. Delaney, M. Pascaly, P. K. Bhattacharya, K. Han, J. K. Barton, Inorg. Chem. 2002, 41, 1966-1974.
J. K. Barton, E. D. Olmon, P. A. Sontz, Coord. Chem. Rev. 2011, 255, 619-634.
B. Elias, A. Kirsch-De Mesmaeker, Coord. Chem. Rev. 2006, 250, 1627-1641, and references cited therein.
L. Marcélis, J. Ghesquière, K. Garnir, A. Kirsch-De Mesmaeker, C. Moucheron, Coord. Chem. Rev. 2012, 256, 1569-1582.
J. Ghesquière, S. Le Gac, L. Marcélis, C. Moucheron, A. Kirsch-De Mesmaeker, Curr. Top. Med. Chem. 2012, 12, 185-196, and references cited therein.
L. Marcélis, C. Moucheron, A. Kirsch-De Mesmaeker, Philos. Trans. R. Soc. A 2013, 371, 1995, and references cited therein.
L. Jacquet, J. M. Kelly, A. Kirsch-De Mesmaeker, J. Chem. Soc., Chem. Commun. 1995, 913-914.
A. Reschner, S. Bontems, S. Le Gac, J. Lambermont, L. Marcélis, E. Defrancq, P. Hubert, C. Moucheron, A. Kirsch-De Mesmaeker, M. Raes, J. Piette, P. Delvenne, Gene Ther. 2013, 20, 435-443.
S. Le Gac, S. Rickling, P. Gerbaux, E. Defrancq, C. Moucheron, A. Kirsch-De Mesmaeker, Angew. Chem. Int. Ed. 2009, 48, 1122-1125.
S. Le Gac, M. Surin, E. Defrancq, C. Moucheron, A. Kirsch-De Mesmaeker, Eur. J. Inorg. Chem. 2013, 208-216.
M. Villien, S. Deroo, E. Gicquel, E. Defrancq, C. Moucheron, A. Kirsch-De Mesmaeker, P. Dumy, Tetrahedron 2007, 63, 11299-11306.
S. Deroo, E. Defrancq, C. Moucheron, A. Kirsch-De Mesmaeker, P. Dumy, Tetrahedron Lett. 2003, 44, 8379-8382.
W. Im, M. S. Lee, C. L. Brooks, J. Comput. Chem. 2003, 24, 1691-1702.
Molecular graphics images were produced by using the UCSF Chimera package from the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco (supported by NIH P41 RR-01081).