[en] Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among head and neck cancers. Despite a lower incidence of laryngeal carcinoma, new diagnostic techniques, and more targeted therapies, the overall survival has not changed significantly in the last decades, leading to a negative prognosis in advanced stages. Recently, several studies have focused on the identification of biomarkers that may play a critical role in the pathogenesis of LSCC. Reviewing the literature on the main databases, this study aims to investigate the role of some biomarkers in LSCC that are correlated with oxidative stress and inflammation: heat shock proteins; metallothioneins; nuclear factor erythroid 2-related factor 2; heme oxygenase; cyclooxygenase-2; and micro ribonucleic acids. This review shows that biomarker expression depends on the type, grade of differentiation, stage, and site of carcinoma. In addition, the role of these biomarkers in LSCC is still little-known and little-studied. However, the study of biomarker expression and the detection of a possible correlation with patients' epidemiological, clinicopathological, and therapeutics data may lead to better awareness and knowledge of the tumor, to the identification of the best therapeutic strategy, and the most proper follow-up protocol tailored for each patient. In conclusion, the achievement of these goals may improve the prognosis of LSCC patients.
Disciplines :
Otolaryngology
Author, co-author :
Verro, Barbara ; Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy
Saraniti, Carmelo ; Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy
Carlisi, Daniela ; Section of Biochemistry, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy
Chiesa-Estomba, Carlos; Head and Neck Surgery Research Group of Young Otolaryngologists of International Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France ; Otorhinolaryngology-Head & Neck Surgery Department, Donostia University Hospital, Biodonostia Research Institute, Faculty of Medicine, Deusto University, 20014 Donostia, Spain
Maniaci, Antonino; Head and Neck Surgery Research Group of Young Otolaryngologists of International Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France ; Faculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy
Lechien, Jérome ; Université de Mons - UMONS > Faculté de Psychologie et des Sciences de l'Educatio > Service de Métrologie et Sciences du langage
Mayo, Miguel ; Head and Neck Surgery Research Group of Young Otolaryngologists of International Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France ; Department of Otorhinolaryngology-Head and Neck Surgery, Complexo Hospitalario Universitario A Coruña (CHUAC), 15006 A Coruña, Spain ; Department of Otorhinolaryngology-Head and Neck Surgery, Hospital San Rafael (HSR), 15006 A Coruña, Spain
Fakhry, Nicolas; Head and Neck Surgery Research Group of Young Otolaryngologists of International Federation of Otorhinolaryngological Societies (YO-IFOS), 75000 Paris, France ; Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, Assistance Publique-Hopitaux de Marseille, Aix Marseille University, 13005 Marseille, France
Lauricella, Marianna ; Section of Biochemistry, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90127 Palermo, Italy
Language :
English
Title :
Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review.
Publication date :
22 October 2023
Journal title :
Cancers
eISSN :
2072-6694
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
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