[en] [en] OBJECTIVE: To determine if chronic insomnia alters the relationship between heart rate variability and delta sleep determined at the EEG.
METHODS: After one night of accommodation, polysomnography was performed in 14 male patients with chronic primary insomnia matched with 14 healthy men. ECG and EEG recordings allowed the determination of High Frequency (HF) power of RR-interval and delta sleep EEG power across the first three Non Rapid Eye Movement (NREM)-REM cycles. Interaction between normalized HF RR-interval variability and normalized delta sleep EEG power was studied by coherency analysis.
RESULTS: Patients showed increased total number of awakenings, longer sleep latency and wake durations and shorter sleep efficiency and REM duration than controls (p<.01). Heart rate variability across first three NREM-REM cycles and sleep stages (NREM, REM and awake) were similar between both groups. In each group, normalized HF variability of RR-interval decreased from NREM to both REM and awake. Patients showed decreased linear relationship between normalized HF RR-interval variability and delta EEG power, expressed by decreased coherence, in comparison to controls (p<.05). Gain and phase shift between these signals were similar between both groups.
CONCLUSIONS: Interaction between changes in cardiac autonomic activity and delta power is altered in chronic primary insomniac patients, even in the absence of modifications in heart rate variability and cardiovascular diseases.
SIGNIFICANCE: This altered interaction could reflect the first step to cardiovascular disorders.
Disciplines :
Neurology
Author, co-author :
Jurysta, F; Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, Free University of Brussels, 1070 Brussels, Belgium. fabrice.jurysta@erasme.ulb.ac.be
Lanquart, J-P; Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, 1070 Brussels, Belgium
Sputaels, V; Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, 1070 Brussels, Belgium
Dumont, Martine ; Université de Mons - UMONS > Faculté des Sciences > Service Décanat-Site Mons de la Faculté des Sciences
Migeotte, P-F; Biomedical Physics Laboratory, Free University of Brussels, Belgium
Leistedt, SAMUEL ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > Service du Doyen de la Faculté de Médecine et Pharmacie ; Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, 1070 Brussels, Belgium
Linkowski, Paul ; Université de Mons - UMONS > Faculté de Médecine et de Pharmacie > FMP - Service du Doyen ; Sleep Laboratory, Department of Psychiatry, Erasmus Academic Hospital, 1070 Brussels, Belgium
van de Borne, P; Department of Cardiology, Hypertension Clinic, Erasmus Academic Hospital, Belgium
Language :
English
Title :
The impact of chronic primary insomnia on the heart rate--EEG variability link.
We thank Bernard Jacques for his technical assistance, Chantal Kempenaers for her critical reading of the manuscript, Jennifer Barr for her grammatical and orthographic corrections, and all other members of the sleep laboratory for their active participation. Research reported in this paper was supported by the Erasmus Foundation, the Belgian National Fund of Scientific Research (FNRS), the Rene Saucez-Emile Van Poucke Foundation, the Foundation for Cardiac Surgery, and the Lambertine Lacroix Prize.
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